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【EXPERT Q&A】The buyer has started to ask about the annual purchase volume and long-term pricing. At which stage has this inquiry progressed?

Drugdu.com expert’s response: In pharmaceutical foreign trade inquiries, many communications start off very lightly. Buyers first ask if the product is available, then review the COA, specifications, and price, and sometimes request samples. At this stage, suppliers are mostly confirming product compatibility, while buyers are still screening options. However, when the conversation progresses to the point where buyers start asking about annual purchase volumes, long-term pricing, and stable supply capabilities, the situation changes. For example, if a buyer begins to inquire about how much goods they will need in a year, whether quarterly deliveries are possible, and if prices can be recalculated for long-term cooperation, such questions usually indicate that they are no longer just considering “whether they can make a single purchase” — they are assessing whether the supplier can be included in their long-term cooperation network. Of course, this does not mean an order will be placed immediately. ...
- Source: drugdu
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- September 30, 2026
Novo Nordisk and Nanexa Ink Up to €1.165B Long-Acting Delivery Deal for Obesity and Diabetes

On September 25, Swedish pharma company Nanexa announced an exclusive global license and collaboration agreement with Novo Nordisk, leveraging Nanexa’s PharmaShell atomic layer deposition technology for up to five peptide programs. Novo Nordisk gains exclusive global rights to develop and commercialize up to five peptide programs in obesity and type 2 diabetes using PharmaShell. Nanexa receives an undisclosed upfront payment, up to €1.165B in development, regulatory and commercial milestones, plus royalties. The deal further strengthens Novo’s obesity pipeline through long-acting delivery beyond GLP-1. Source: https://www.biobucks.co/biotech-bdl-tracker-2026
- Source: drugdu
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- September 29, 2026
siRNA Biotech ADARx Raises $446M in 2026’s Third-Largest Biotech IPO

On September 24, San Diego-based siRNA therapeutics company ADARx Pharmaceuticals priced an upsized IPO of 26.25 million shares at $17.00 per share (top of the $15-$17 range), raising $446.3 million—the third-largest biotech IPO of 2026. Shares began trading on Nasdaq on September 25 under ticker ADRX. ADARx’s lead asset onvuzosiran targets hereditary angioedema (HAE), with topline data from the pivotal Phase 3 STOP-HAE trial expected by late 2027. Partner AbbVie also invested approximately $89 million in a concurrent private placement, taking a 4.9% stake. The IPO underscores continued capital market enthusiasm for RNAi therapeutics in 2026. Source: https://www.globenewswire.com/news-release/2026/09/24/3368818/0/en/adarx-pharmaceuticals-announces-pricing-of-upsized-446-3-million-initial-public-offering.html
- Source: drugdu
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- September 29, 2026
Merck and Eisai’s Welireg Plus Lenvima Approved by FDA for Previously Treated Advanced Kidney Cancer

On September 25, Merck (MSD) and Eisai announced FDA approval of Welireg® (belzutifan), an oral HIF-2α inhibitor, in combination with Lenvima® (lenvatinib), for adults with advanced renal cell carcinoma (ccRCC) with a clear cell component previously treated with a PD-1 or PD-L1 inhibitor. The approval is based on the LITESPARK-005 Phase 3 study, which showed the Welireg+Lenvima combination reduced the risk of disease progression or death by 30% versus cabozantinib. This provides a new all-oral option for patients after immunotherapy failure. Source: https://www.merck.com/news/welireg-belzutifan-plus-lenvima-lenvatinib-reduced-the-risk-of-disease-progression-or-death-by-30-compared-to-cabozantinib-in-certain-previously-treated-patients-with-advanced-renal-ce/
- Source: drugdu
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- September 29, 2026
Mirum and Incyte’s Atebrioz Wins FDA Approval for Rare Bone Disorder FOP

On September 25, Mirum Pharmaceuticals and Incyte announced that the U.S. FDA approved Atebrioz™ (zilurgisertib) to reduce new heterotopic ossification (HO) volume in patients aged 12 and older with fibrodysplasia ossificans progressiva (FOP). Zilurgisertib is a once-daily oral small-molecule inhibitor of activin receptor-like kinase 2 (ALK2), directly blocking the key signaling pathway driving abnormal bone formation in soft tissue. FOP is an ultra-rare progressive genetic disorder in which soft tissue gradually ossifies, causing severe mobility impairment. The approval was based on the pivotal Phase 2 PROGRESS study. Mirum licensed worldwide rights from Incyte. Source: https://ir.mirumpharma.com/news/news-details/2026/Mirum-Pharmaceuticals-and-Incyte-Announce-U-S–FDA-Approval-of-Atebrioz-zilurgisertib-for-Adult-and-Pediatric-Patients-with-Fibrodysplasia-Ossificans-Progressiva/default.aspx
- Source: drugdu
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- September 29, 2026
J&J in Talks to Sell DePuy Synthes to Apollo

Johnson & Johnson is in talks to sell its orthopedics business DePuy Synthes to private equity firm Apollo Global Management for approximately $20 billion. DePuy Synthes was formed from J&J’s 1998 ($3.5B) and 2012 ($21.3B) acquisitions of DePuy and Synthes, covering joint reconstruction, sports medicine, trauma, and the Velys orthopedic surgical robot.DePuy Synthes generated $9.258B in 2025, growing only 1.1% vs. 6.1% for J&J’s broader MedTech segment. Stryker overtook it as global #1 in orthopedics with ~$11.4B. Chinese centralized procurement also pressures the business. H1 2026 sales were $4.801B (+5.6%), showing recovery. J&J has not officially announced the deal; a spin-off remains an option. Source: https://news.yaozh.com/archive/49060.html
- Source: drugdu
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- September 29, 2026
APAC Leadership Transition and Cyberattack Hits Full-Year Guidance

Boston Scientific announced that Arthur Butcher, EVP and Head of International MedSurg, will retire. Butcher joined in 1996, served as EVP & President of Asia Pacific from 2020-2022, and has led MedSurg & APAC Group since 2022 after over 30 years with the company. He will step down on January 1, 2027. Boston Scientific has also been recovering from a major cyberattack identified on August 25, 2026 that disrupted global operations. On September 8, the company stated the incident could materially impact Q3 and full-year results, and it expects to miss prior net sales growth and adjusted EPS guidance. This follows a July 29 guidance cut to 5%-6% organic growth due to slowing electrophysiology and Watchman momentum. Source: https://news.yaozh.com/archive/49062.html
- Source: drugdu
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- September 29, 2026
Huadong Medicine Discloses Positive Top-line Results for Weight-loss Drug, Pipeline May Be Revalued

Huadong Medicine announced that its wholly-owned subsidiary Sino-American East China has achieved positive top-line results in the China Phase III trial (HDM1002-301) of its Class 1 innovative oral small-molecule GLP-1 receptor agonist HDM1002 tablets for weight management in overweight or obese individuals. All dosage groups met all primary and key secondary endpoints at week 44; continued treatment resulted in sustained weight loss further decreasing at week 52 without a plateau; significant improvements in cardiometabolic markers, substantial reduction in liver fat content, and optimized body composition were observed; safety and tolerability were consistent with the GLP-1 class with no new signals. The company has completed Pre-NDA communication and will soon submit a marketing application in China. Research institutions indicate the biopharmaceutical industry will benefit from upcoming policies, with related companies expected to see improved performance. Source: https://finance.eastmoney.com/a/202609283885024341.html
- Source: drugdu
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- September 29, 2026
Core Product Velyso Granted Orphan Drug Designation in Japan

On September 28, Leads Biolabs-B (09887) announced that its core product Velyso® (opatidijumimab, a PD-L1/4-1BB bispecific antibody) has been granted orphan drug designation by the Japanese Ministry of Health, Labour and Welfare for the treatment of extrapulmonary neuroendocrine carcinoma (EP-NEC). This is the third orphan drug designation that Velyso® has received, following those from the U.S. Food and Drug Administration and the European Commission, marking a further expansion of its global regulatory recognition into major Asian markets. Source: https://finance.eastmoney.com/a/202609283885132814.html
- Source: drugdu
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- September 29, 2026
Healthcare Facilities Symposium & Expo

、 Organiser： Austin International Medical Association Time：September 28-30, 2026 Address：501 S College St, Charlotte, NC 28202, USA Exhibition hall：CHARLOTTE CONVENTION CENTER Product range: ‌Medical Equipment‌: Medical equipment, electronic medical instruments, dental equipment ‌Testing, Analysis & Diagnostic Instruments‌: Testing, analysis and diagnostic instruments, monitoring instruments ‌Medical Consumables‌: Consumables, disposable products, cotton and linen medical textiles ‌Medical Furniture‌: Medical furniture ‌Assistive Products‌: Assistive products for people with disabilities ‌Nursing & Rehabilitation Equipment‌: Nursing and rehabilitation instruments ‌Cleaning, Disinfection & Sterilization Products‌: Cleaning, disinfection and sterilization products ‌Pharmaceuticals & Nutritional Health Products‌: Pharmaceuticals and nutritional health products ‌Medical Packaging‌: Medical packaging About Healthcare Facilities Symposium & Expo： Healthcare Facilities Symposium & Expo is one of the most important medical device exhibitions in the United States. It aims to create a multidisciplinary environment that inspires change through physical spaces and promotes better healthcare delivery. The previous edition of the Healthcare Facilities Symposium & ...
- Source: drugdu
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- September 29, 2026

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