Search Results for “AI” – Page 5 – media

Pfizer and Shanghai Pharmaceuticals Reach Strategic Cooperation to Create High-Quality Preventive Immunization Services

On September 26, Pfizer Investment Co., Ltd. (referred to as Pfizer) and Shanghai Pharmaceuticals Holding Co., Ltd. (referred to as Shanghai Pharmaceuticals) signed a strategic cooperation framework agreement. The two parties will focus on the vaccine field, engaging in long-term collaboration in product promotion, the introduction of innovative products, and policy research. Leveraging their respective strengths, they will explore strategies to deepen and enhance their partnership in the commercial promotion of vaccine products and accelerate the introduction of innovative products, along with thorough cooperation in policy research and capacity training. This effort aims to support the robust development of China’s public health services and disease control efforts, ultimately aiding disease prevention and health improvement across all stages of life. Jean-Christophe Pointeau, President of Pfizer China, stated: “The collaboration between Pfizer and Shanghai Pharmaceuticals will harness both parties’ strengths to empower the promotion and dissemination of innovative vaccines scientifically, allowing internationally ...
- Source: drugdu
- 79
- September 29, 2024
Implantation of mesenchymal stem cells significantly improves motor function in patients with brain injury

Traumatic brain injury (TBI) is a heterogeneous disease characterized by brain damage and functional impairment caused by external forces. Under the influence of multiple mechanisms, the disability and mortality rates of TBI patients are relatively high, which imposes a heavy burden on families and society. The clinical treatment of TBI mainly involves surgical intervention and symptomatic treatment to alleviate cerebral hypoxia, cerebral edema, and metabolic disorders. In recent years, stem cells have gradually become one of the research hotspots for TBI treatment.A research team from the United States and Japan published a clinical observation report titled Mesenchymal Stromal Cell Implants for Chronic Motor Defects After Traumatic Brain Injury in the Neurology journal on September 4, 2024. The researchers found that implanting mesenchymal stem cell (SB623) cells can help TBI patients restore motor function and daily life skills.Traumatic brain injury (TBI) is the leading cause of death and disability in trauma ...
- Source: drugdu
- 91
- September 28, 2024
Brief Bioinform | Li Shiliang/Li Honglin team develops AI method GR pKa value prediction for small molecules based on retention mechanism

Zhiyao Bang The following article is from DeDrug, authored by Li’s Lab On August 22, 2024, the team of Professor Li Shiliang/Li Honglin from East China University of Science and Technology/East China Normal University published a research paper titled “GR pKa: A message feeding neural network with retention mechanism for pKa prediction” in the journal Briefing in Bioinformatics. This paper introduces an innovative deep learning model GR pKa for predicting the pKa values of small chemical molecules. This model combines multiple fidelity learning, quantum chemistry features, and retention mechanisms to achieve rapid and accurate prediction of pKa values of small chemical molecules, providing a powerful new tool for research in the fields of chemistry and pharmacy. Research background In the process of drug discovery and design, the acid-base dissociation constant (pKa) of molecules has a significant impact on the characteristics (absorption, distribution, metabolism, excretion, and toxicity) and biological activity of ...
- Source: drugdu
- 79
- September 27, 2024
2 injections for 1 year, a preview of conquering AIDS

Since June 2024, all scholars around the world who care about AIDS prevention have focused their attention on Gilead’s antiviral drug lenacapavir. At that time, Gilead announced the latest data of the PURPOSE 1 trial conducted by lenacapavir, and the results showed that: in the case of head-to-head daily oral PrEP drugs, lenacapavir achieved 0 infection with 2 injections per year. This means that in the case of unfavorable vaccine development, lenacapavir is expected to replace the preventive effect of the vaccine with its ultra-persistent prevention characteristics. Of course, is the result of the PURPOSE1 trial accidental or inevitable? No one can give an answer. But in September, Gilead continued to provide PURPOSE 2 trial data, indicating to the outside world that the possibility of inevitability is greater. The results showed that 99.9% of the participants in the Lenacapavir group were not infected with HIV, and the risk of infection ...
- Source: drugdu
- 71
- September 27, 2024
Ocuvision nails first generic anti-allergic eye drop

Last week (September 9 to September 15), a total of 58 varieties passed/were deemed to have passed the consistency evaluation. During the same period, 123 varieties applied for consistency evaluation. According to the official website of NMPA, Suzhou Ocuvision Biotechnology Co., Ltd. (hereinafter referred to as “Ocuvision”)’s cetirizine hydrochloride eye drops obtained a marketing approval on September 10. The drug is indicated for the treatment of itchy eyes associated with allergic conjunctivitis and is suitable for people aged 2 years and above. Allergic conjunctivitis is an allergic disease of the eye that occurs more frequently in spring and autumn. The disease is mainly manifested by itchy eyes, accompanied by red and swollen eyelids, congestion and edema of the conjunctiva (white eyeballs), increased tears or white secretions, and some patients also have symptoms such as nasal congestion, itchy nose, clear runny nose, and sneezing. Cetirizine hydrochloride eye drops are one of ...
- Source: drugdu
- 84
- September 26, 2024
Stryker InSpace Balloon Obtains C Code! Revolutionary Treatment for Huge, Irreparable Rotator Cuff Tears

After being approved for marketing in China, the absorbable implantable balloon InSpace System (hereinafter referred to as InSpace absorbable implantable balloon) developed and produced by Stryker has made another major breakthrough. On September 20, after strict review by the National Medical Insurance Administration, the product obtained the medical insurance medical consumables code (hereinafter referred to as C code), laying the foundation for obtaining the qualification for online procurement in various provinces in the next step. In July this year, the Medical Device Technology Review Center of the State Food and Drug Administration approved the marketing application of InSpace absorbable implantable balloon in China for the treatment of huge, irreparable, full-thickness tears of rotator cuff tendons caused by trauma or degeneration. As the only shoulder joint implantable balloon approved for marketing in the world by 2024, the product can be implanted under the acromion through minimally invasive surgery to restore shoulder ...
- Source: drugdu
- 85
- September 26, 2024
The chairman of Sinopharm Holdings has been replaced, and he comes from China Resources Group

Recently, Sinopharm Holdings issued an announcement on changes in the composition of the board committee, and Zhao Bingxiang was appointed as a non-executive director of Sinopharm. According to the process at the end of August, “the board of directors of Sinopharm has decided to elect Zhao Bingxiang as chairman of the board of directors. This appointment must be approved by shareholders at the shareholders’ meeting before the appointment of its non-executive director can take effect.” Zhao Bingxiang’s appointment as a non-executive director of Sinopharm also means that His appointment as chairman of the state-controlled company takes effect. At present, Sinopharm’s official website and announcement information have been updated, and Zhao Bingxiang serves as the chairman, non-executive director and party committee secretary of Sinopharm Holdings. It is reported that Zhao Bingxiang has worked in the China Resources department for a long time. He has served as a senior researcher at the ...
- Source: drugdu
- 64
- September 24, 2024
Lepu Biotech’s Injection of Vebecotamab Aiming for Priority Review for Nasopharyngeal Carcinoma

On September 19, the National Medical Products Administration (NMPA) released a public notice on its drug evaluation center’s official website, announcing that Lepu Biotech’s injection of Vebecotamab is proposed for priority review. This treatment is intended for patients with recurrent or metastatic nasopharyngeal carcinoma who have previously failed at least two lines of systemic chemotherapy and PD-1/PD-L1 inhibitor therapies. This drug, developed by Lepu Biotech, is an antibody-drug conjugate (ADC) targeting EGFR, with the development code MRG003. It is composed of an EGFR-targeted monoclonal antibody linked to a potent microtubule inhibitor, MMAE, through a vc linker. The molecular design of this drug has the potential to extend its application to a broader range of cancers that overexpress EGFR and may overcome various types of resistance caused by common mutations. In its previously published semi-annual report, Lepu Biotech indicated plans to submit a new drug application (NDA) for MRG003 to the ...
- Source: drugdu
- 76
- September 23, 2024
AstraZeneca’s “Class 1 Anti-heart Failure Chemical Drug” has applied for clinical trials in China

On September 14, according to the official website of CDE, AstraZeneca’s clinical trial application for the Class 1.1 chemical drug AZD5462 tablets was accepted. According to public information, the drug is a relaxin RXFP1 receptor agonist. Relaxin, as an agonist of the relaxin 1 receptor (RXFP1), produces unique and diverse biological effects, including pulmonary and systemic vasodilation, tissue remodeling/fibrosis reversal, and reduced inflammation, and therefore also has potential in cardiopulmonary diseases. significant curative effect. In addition, this substance is also known as the “pregnancy hormone” and is regulated during pregnancy to help the expectant mother’s cardiovascular system meet the increased demands of the developing fetus and remodel tissue and musculoskeletal structure. . AZD5462 is a relaxin RXFP1 receptor agonist developed by AstraZeneca. Preclinical studies on monkey models of heart failure with reduced ejection fraction (HFrEF) showed that cardiac systolic function was improved after 8 weeks of treatment. There was no ...
- Source: drugdu
- 83
- September 23, 2024
Nat Microbiol | Liu Wei/Li Hao reveal new mechanism of bile acid protection against SFTSV (fever with thrombocytopenia syndrome) infection

BioArt September 19, 2024 08:45 Shanghai Bile acids are metabolites produced by the synergistic effect between the host and its gut microbiota. They can regulate various biological functions and affect the host’s susceptibility to viral infections, especially enteroviruses and hepatitis viruses, by activating specific receptors and cellular signaling pathways in intestinal and liver tissues. A small fraction (<10%) of total bile acids can enter the systemic circulation and may play a critical role in antiviral immunity during systemic infections. However, the function and mechanism of bile acids in regulating the host’s immune response to viral systemic infections are still poorly understood, and the association between bile acid metabolism and disease outcomes of viral systemic infections is also unclear. Viral hemorrhagic fever is usually caused by highly pathogenic RNA viruses, which can lead to severe systemic infections, multiple organ failure, and even death. Severe fever with thrombocytopenia syndrome (SFTS) is a ...
- Source: drugdu
- 85
- September 21, 2024

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