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A tumultuous time for the king of orphan drugs

More than 20 years ago, research on rare diseases and the treatment of rare diseases were very rare in the medical community. The small market size of rare diseases and the huge difficulty in research and development have made pharmaceutical companies shy away from this field. In the past 25 years, BioMarin has launched eight rare disease drugs with strong R&D capabilities. Arguably, this record is unmatched by few companies in the biotech industry. However, with the failure of the commercialization of its highly-anticipated hemophilia A gene therapy, Roctavian, a strategic review began. Since the beginning of this year, BioMarin has been in turmoil. Over the past nine months, there have been layoffs, executive restructuring, spending cuts, and research projects on hold. With the reshuffle of the business structure and the arrival of new competition, it remains to be seen when BioMarin will be able to get out of this ...
- Source: drugdu
- 89
- October 14, 2024
【EXPERT Q&A】What are the precautions for import and export goods entering and leaving the customs?

Drugdu.com expert’s response: When importing and exporting goods through customs, various aspects need to be taken into consideration to ensure smooth customs clearance and compliance with relevant regulations. Here are some key considerations: Ⅰ. Documentation Preparation Complete and Accurate Documentation: Import-export enterprises must prepare complete documents, including bills of lading, invoices, packing lists, contracts, import-export licenses (if required), certificates of origin, inspection and quarantine certificates, etc. These documents must be accurate and in line with customs requirements. Compliant Declaration: Ensure that the declared information for goods is accurate, including commodity names, quantities, values, origins, etc. The declared value should match the actual value to avoid issues arising from over- or under-declaration. Ⅱ. Commodity Classification and Taxation Accurate Classification: Accurate classification of goods is crucial, as it directly determines the Harmonized System (HS) code, which further influences tariff rates and regulatory conditions. Misclassification can lead to unnecessary troubles and losses. Tax ...
- Source: drugdu
- 86
- October 14, 2024
Dental laser equipment boss, bankruptcy and acquisition

On October 9, 2024, Biolase, which occupies the top spot in the world’s dental laser equipment, announced that it has signed an agreement to sell the majority of the company’s assets to rival Sonendo for $14 million. Biolase Company of United States, the world’s leading oral laser expert, has long been committed to the research and development and manufacturing of full-function lasers, with a global laser market share of 70%. However, due to long-term losses, the stock price continued to be depressed, and it was delisted from the Nasdaq in June this year and declared bankruptcy on October 1. The buyer of the acquisition, Sonendo, a dental giant dedicated to root canal treatment devices, sued Biolase in 2023 for a patent dispute, claiming no less than $59 million in damages. This acquisition not only marks the end of an era for the giant Biolase, but also announces the end of ...
- Source: drugdu
- 87
- October 14, 2024
Nationally sourced intraocular lenses, who is the winner?

On August 30, 2024, the Shanghai Pharmaceutical Affairs Institute issued a document that the information on products related to the centralized procurement of intraocular lenses and sports medicine organized by the state will be released through the portal on September 3, 2024, and will take effect on September 10, 2024. So far, the fourth batch of national procurement has been implemented in all provinces across the country. The “Notice on the Centralized Procurement and Use of Intraocular Lens and Sports Medicine Medical Consumables Organized by the State” issued by Shanghai marks the full implementation of the fourth batch of high-value consumables in China. This policy has had a significant impact on the medical industry, especially on the intraocular lens market. It is reported that 126 companies were selected in this national procurement, involving 30 product categories, and the average price reduction of the selected products was 70%, of which the ...
- Source: drugdu
- 80
- October 14, 2024
intensified BD trading competition in the pharmaceutical market, pharmaceutical companies launch market competition war

Source: 21st Century Business Herald Has the cow arrived? The A-share market is booming, don’t miss the opportunity, open an account and layout now>> Recently, there has been a frequent wave of business development (BD) cooperation transactions between Chinese and foreign pharmaceutical companies. On October 9th, Baiaotai announced that it has reached an authorization license, production, supply, and commercialization agreement with Gedeon Richter Plc. for BAT2206 (ustekinumab) injection solution. According to the agreement, Baiaotai will license the exclusive commercial rights of the injection in the EU, UK, Switzerland, Australia, and other European markets to Gedeon Richter Plc for a fee. The amount involved in this transaction includes a down payment of $8.5 million, milestone payments up to a cumulative total of $101.5 million, and revenue sharing based on a double-digit percentage of net sales. In addition to Baiaotai, several Chinese pharmaceutical companies have also recently received positive news regarding BD ...
- Source: drugdu
- 104
- October 12, 2024
14.1 billion, Johnson&Johnson announces big move

On October 9th, Johnson&Johnson announced plans to invest over $2 billion (approximately RMB 14.1 billion) in Wilson, North Carolina to build an advanced biopharmaceutical manufacturing facility to support its growing portfolio of biologic therapy products in oncology, immunology, and neuroscience. It is reported that this measure is in line with Johnson&Johnson’s broader strategy of submitting or launching over 70 new therapies and product expansions by the end of the next decade. The new facility will be equipped with cutting-edge technology, which will not only enhance global production capacity, but also provide approximately 420 high skilled full-time positions for the local area. The project will begin construction in the first half of 2025. In August of this year, in order to strengthen its position in the cardiovascular field, Johnson&Johnson announced the acquisition of V-Wave, a company specializing in heart failure treatment technology. Prior to this, Johnson&Johnson acquired for approximately $13.1 billion ...
- Source: drugdu
- 99
- October 12, 2024
Dental laser equipment leader, bankrupt and acquired

On October 9, 2024, Biolase, which dominates the global dental laser equipment market, announced that it has signed an agreement to sell most of its assets to competitor Sonendo for $14 million. Biolase, a leading dental laser expert in the world, has long been committed to the research and manufacturing of fully functional lasers, with a global laser market share of 70%. But due to long-term losses, the stock price remained low, and it was delisted from NASDAQ in June this year, and declared bankruptcy on October 1st. The buyer of this acquisition case, Sonendo, is a dental giant dedicated to root canal treatment equipment. Its subsidiary sued Biolase in 2023 for a patent dispute and demanded compensation of no less than $59 million. This acquisition not only marks the end of an era for giant Biolase, but also declares the end of the aforementioned patent dispute. 01. The world’s ...
- Source: drugdu
- 106
- October 12, 2024
A new star in the 10 billion respiratory market, a new generation of ICS drugs is heavily recruited!

Asthma/COPD is a common respiratory disease in my country, with more than 53 million asthma patients. The prevalence rate in adults is 4.2%, and the prevalence rate in children is 3.07%, with about 7.6 million children. According to statistics, about 30% of urban children with asthma are not diagnosed in time, and more than 20% of children with asthma are not well controlled. There is a huge unmet clinical demand. According to the guideline data, the prevalence of COPD in adults aged 20 and above in my country is 8.6%, and that in adults aged 40 and above is as high as 13.7%. It is estimated that the number of COPD patients in my country is nearly 100 million. According to the full-terminal data of the hospital market of Yaorongyun, although the asthma/COPD drug market has fluctuated due to external factors such as the epidemic and centralized procurement, it has ...
- Source: drugdu
- 105
- October 12, 2024
Twinings Biopharmaceuticals, Lingrui, Hisun…

As of the first three quarters, there were 9 pharmaceutical stocks with a market value of 100 billion yuan, with Mindray Medical firmly in the top spot and Hengrui Medicine returning to a market value of 300 billion yuan. In terms of quantity, there were 4 more stocks compared with the first half of the year, with Aier Eye Hospital, Yunnan Baiyao, United Imaging Healthcare, and Wantai Biopharma returning to the 100 billion yuan market value echelon. Among the TOP20, 15 stocks have positive growth, with Hengrui Medicine, BeiGene, Yunnan Baiyao, Shanghai Pharmaceuticals, China Resources Sanjiu, Baili Tianheng and 10 other stocks growing at a rate of more than 10%; while in the first half of the year, only 6 stocks had positive growth, with 4 other stocks growing at a rate of more than 10%, including Shanghai Pharmaceuticals and China Resources Sanjiu. Mindray Medical has firmly established itself as ...
- Source: drugdu
- 97
- October 12, 2024
New president of Beckman takes office

Recently, according to the official website of Beckman Coulter Life Sciences, Danaher subsidiary Beckman Coulter Life Sciences (hereinafter referred to as Beckman) announced the appointment of Joe Fox as president, effective immediately. It is understood that Joe Fox is a veteran of Danaher. He served as president of Danaher subsidiary Sciex, and before becoming president, he held several leadership positions in the company, including senior vice president of global sales and services. In 13 years, Joe Fox has held positions with increasing responsibilities until he became president recently. Before joining Sciex, Joe Fox held technical and commercial positions at Bruker and Shimadzu, and Joe Fox also holds a degree in biochemistry from the University of Delaware and a doctorate in chemistry from Johns Hopkins University. After taking office, Joe Fox will lead a global team of more than 3,300 employees to promote product and service innovation to provide solutions in ...
- Source: drugdu
- 107
- October 12, 2024

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