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BeiGene’s “BTK Double Swords” Unleashed

When it comes to BeiGene’s BTK, you will think of zanubrutinib without thinking, but BeiGene’s BTK inhibitors are not limited to zanubrutinib. BGB-16673, which is under development in the pipeline, is another potential “sharp sword”. Recently, BeiGene’s BTK PROTAC molecule BGB-16673 was granted fast track qualification by the FDA for CLL/SLL patients who have undergone at least two lines of treatment, including BTK inhibitors and Bcl-2 inhibitors. Since the first BTK inhibitor ibrutinib was approved for marketing in 2013, 6 BTK inhibitors have been approved for marketing worldwide. Although many BTK inhibitors have been approved for marketing and these drugs have demonstrated excellent efficacy, they still have certain limitations, namely the problem of drug resistance. PROTAC (protein degradation) has been a very hot research and development track in recent years. Compared with small molecule inhibitors, PROTAC degraders have many advantages: they expand the druggable targets and can target target proteins ...
- Source: drugdu
- 84
- September 3, 2024
Tumor drugs without OS are also hanging in China

Before this, furiquintinib was regarded as another effective treatment option for gastric cancer patients. After all, gastric cancer is the fifth most common cancer in the world, and my country is a country with a high incidence of gastric cancer, with a large number of patients. With the continuous development of precision medicine, PD-1 combined with chemotherapy has become a new standard for first-line treatment of advanced gastric cancer. However, both in China and around the world, there is still a lack of treatment options available for second-line and above patients. Global pharmaceutical companies have deployed a large number of research in this field to promote clinical trials including PD-1, ADC, and VEGFR inhibitors. Among them, VEGFR inhibitors play a vital role in inhibiting tumor angiogenesis, and studies have shown that gastric cancer tissues often express high levels of VEGF, which is associated with more advanced disease and poor prognosis. ...
- Source: drugdu
- 88
- September 3, 2024
Focusing on complement, standardized diagnosis and treatment of rare diseases usher in a new chapter

So far, the 2024 medical insurance catalog adjustment has announced the drugs and related information that have passed the formal review. From the draft for comments, rare disease drugs are still one of the focuses of the medical insurance catalog adjustment. Rare diseases are also called “orphan diseases”. Most of them are congenital diseases, chronic diseases, and may be life-threatening. Although the incidence of rare diseases is low, there are many types of diseases and the number of patients cannot be underestimated. At present, there are more than 7,000 confirmed rare diseases in the world, and there are about 20 million rare disease patients in China1. For a long time, the clinical phenotypes of rare diseases and common diseases overlap greatly, and early diagnosis is difficult, so the misdiagnosis and missed diagnosis rates are high. According to statistics from the National Organization for Rare Diseases in the United States, among ...
- Source: drugdu
- 54
- September 3, 2024
stable and improving performance in ringgit, the benefits of overseas market development gradually appeared

On August 28, Buchang Pharma (603858) released its 2024 semi-annual report. During the report period, the company realized operating income of 5.432 billion yuan; realized attributable net profit of 231 million yuan; net cash flow from operating activities was 497 million yuan, an increase of 85.62%, the company’s cash reserves are more adequate. In the context of general industry pressure, Buchang Pharma still shows the strong operating resilience of leading enterprises. During the reporting period, the company actively carried out research and development of multiple types of drugs and gradually perfected the big health industry. Since its establishment, Buchang Pharma has become an important force in promoting local economic development. As of July 2024, Buchang Pharma has accumulated more than 30 billion yuan in national tax payments, making significant contributions to the sustainable and sound development of the local economy. According to statistics, since the listing of eight years, Buchang ...
- Source: drugdu
- 57
- September 3, 2024
【EXPERT Q&A】What are the advantages and disadvantages of antibody drugs versus RNA drugs?

Drugdu.com expert’s response: Antibody drugs and RNA drugs are two distinct categories of biotechnology medications, each possessing unique strengths and weaknesses. Below is a detailed analysis of their respective advantages and disadvantages: Ⅰ. Advantages of Antibody Drugs High Specificity: Antibody drugs can specifically recognize and bind to target antigens, typically proteins on cell surfaces, providing a high degree of selectivity that minimizes damage to normal cells. Long-lasting Effect: Antibody drugs typically have longer half-lives, enabling extended duration of action within the body, reducing the frequency of dosing and enhancing patient convenience. Low Immunogenicity: Fully humanized antibody drugs exhibit lower immunogenicity, mitigating the risk of immune reactions and improving drug tolerability and safety. High Success Rate: In clinical studies, antibody drugs demonstrate significantly higher success rates compared to traditional small-molecule chemical drugs. In the US, approximately 25%-30% of large-molecule drugs (including antibody drugs) entering clinical trials are ultimately approved for market, ...
- Source: drugdu
- 75
- September 2, 2024
Tiktok is so convenient for selling medicines and medical devices

Tiktok is so convenient for selling medicines and medical devices! Tiktok, as the world’s leading short video platform, has a huge user base covering all age groups and interest areas. This provides a huge potential market for pharmaceutical companies, which can directly reach a large number of target consumers. The platform supports direct links to e-commerce platforms or corporate official websites to facilitate users to purchase. Pharmaceutical and medical device companies can embed purchase links in videos or guide users to follow stores to promote sales conversion. At the same time, through Tiktok’s live broadcast function, companies can also display products, answer user questions, etc., to further promote sales. It’s so convenient! How to do Tiktok well? Pharmaceutical and medical device companies need to make efforts in many aspects such as clear goals, precise positioning, high-quality content, effective conversion and compliant operations to do marketing on Tiktok. Only through continuous optimization ...
- Source: drugdu
- 69
- September 2, 2024
Medtronic platform acquired

Recently, PaceMate, a provider of cardiac remote monitoring solutions, announced that it has successfully acquired Medtronic’s localized cardiac workflow solution Paceart Optima. However, the financial details of the transaction have not yet been disclosed to the public. As an innovator of cardiac health data management solutions, PaceMate has gained wide recognition in recent years for its remote monitoring technology. The integration of the Paceart Optima system is expected to add nearly 1,000 new clinic partners worldwide. For Medtronic, this divestiture is in line with its overall strategy of focusing resources on core innovation and therapeutic advances. PaceMate has further consolidated its market leadership and expanded its global influence by increasing the depth and breadth of its services. Next, Medtronic’s cardiac rhythm management (CRM) business will work closely with PaceMate to ensure a smooth transition. https://mp.weixin.qq.com/s/GQmozVWWkMxQcAebSM4T-Q
- Source: drugdu
- 96
- September 2, 2024
The Nation’s First Stem Cell Drug Production License Issued Cell Therapy Track to Meet the Development Opportunities

Beijing Drug Administration held a half-year working meeting, at which the work of issuing the country’s first stem cell “drug production license” was particularly recognized. According to the search results of “Administrative License Information” on the website of Beijing Drug Administration, Platinum Bio-Excellence Biotechnology (Beijing) Co., Ltd. is the first company to obtain the national stem cell drug production license. The issuance of the Drug Manufacturing License is of epoch-making significance as it is the first drug manufacturing license specifically for stem cell drugs in China. The issuance of the Drug Manufacturing License signifies that the relevant enterprise has obtained the legal qualification and ability to manufacture stem cell drugs. In recent years, with the introduction of policies such as the “14th Five-Year Plan” for the development of bio-economy, China has clearly put forward the development of new technologies such as stem cell therapy, strengthening the synergy between industry, academia, ...
- Source: drugdu
- 71
- September 2, 2024
HEC Pharmaceuticals and Shamshi Technology held a joint laboratory unveiling ceremony

On August 28, 2024, HEC Pharmaceuticals and Deepin Technology held a joint laboratory unveiling ceremony. The joint laboratory of HEC Pharmaceuticals and Deepin Technology focuses on high-value R&D scenarios and technical R&D bottlenecks in the field of biopharmaceuticals, promoting science and technology from The complete closed loop from source innovation to industrial implementation forms a complete closed loop, jointly exploring the industrial transformation and verification of cutting-edge AI technologies. The unveiling ceremony announced the cooperation relationship between the two parties and promoted close cooperation between the two parties in future multi-level projects. Co., Ltd. (hereinafter referred to as East Sunshine Pharmaceutical), as the domestic anti-influenza “top” brand, its anti-influenza drug Kewei® is the top brand of oseltamivir phosphate, and in February this year, it was awarded the The company has obtained three certifications: “the largest oseltamivir production base in the world”, “the largest oseltamivir production in the world in the ...
- Source: drugdu
- 74
- September 1, 2024
First domestic generic! Jimin Kexin’s Ropinirole Hydrochloride Sustained-Release Tablets approved for marketing

Nanjing Hengsheng Pharmaceutical Co., Ltd. (hereinafter referred to as “Nanjing Hengsheng”), a subsidiary of Jimin Trustworthy Group, received the “Drug Registration Certificate” approved and issued by the National Medical Products Administration (NMPA), approving the company’s ropinirole hydrochloride sustained-release tablets (specification: 2mg) for sale. This variety is the first generic drug of ropinirole hydrochloride sustained-release tablets approved for sale in China. It is mainly used to treat patients with Parkinson’s disease in the early, middle and late stages and non-motor symptoms. It is developed by the Innovative Technology Drug Research Institute under Jimin Trustworthy Group and Nanjing Hengsheng is in production. Parkinson’s disease is a common degenerative disease of the elderly nervous system. Symptoms include resting tremor, muscle rigidity, bradykinesia, cognitive impairment, etc. The condition worsens over time, causing great burdens on patients’ families and society. Ropinirole hydrochloride is a new dopamine receptor agonist that can enter the central nervous system ...
- Source: drugdu
- 56
- September 1, 2024

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