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Pfizer’s JAK inhibitor Xeljanz shows benefit in COVID-19 pneumonia

Pfizer’s JAK inhibitor Xeljanz reduced the risk of severe outcomes in hospitalised adult patients with COVID-19 pneumonia who were not on ventilation, according to new study data. The STOP-COVID trial was conduction by Pfizer and the ARO from the Hospital Israelita Albert Einstein in Sao Paolo, Brazil, which was also the trial coordinating centre. Patients were randomised to receive either Xeljanz (tofacitinib) 10mg twice daily plus standard of care (SoC) or placebo twice daily plus SoC for up to 14 days or until hospital discharge. The trial demonstrated a reduced cumulative incidence of death or respiratory failure through day 28 with Xeljanz (18.1%) compared to placebo (29.9%). In addition, death from any cause occurred in 2.8% of Xeljanz-treated patients compared to 5.5% in the placebo group. In the study, serious adverse groups occurred in 14.1% of patients in the Xeljanz group and 12% in the placebo group. Protocol-specified adverse events ...
- Source: drugdu
- 995
- August 25, 2021
Covid-19
China’s Import and Export Market Report of Diabetes Drugs

Diabetes is one of the most common chronic diseases and is mainly classified into type 1 diabetes, type 2 diabetes, gestational diabetes and others. Worldwide, 90% of diabetic patients suffer from type 2 diabetes, which greatly promotes the development of the diabetes drug market.
- Source: Ddu
- 49,933
- August 25, 2021
Ddu College Diabetes Drugs
Ddu College——WHO vaccine pre-certification How to conduct effective consultation?

From November 1st to 2nd, 2018, the annual World Health Organization (WHO) Prequalification (PQ) consultation will be held in Kunming, China. Unlike previous years, this year’s consultation will only take the one-on-one format, namely the World Health Organization Vaccine Pre-Certification Review Team and small meetings of various domestic vaccine manufacturers. Although the part of the centralized consultation meeting will be cancelled, which means companies and international organizations are unable to discuss and share the importance of pre-certification, but it’s believed that after several years of consultations, everyone has already cooked up the importance and significance of pre-certification. Evidence? This year’s 14 vaccine manufacturers actively participate in the one-on-one consultation is the best proof. As of November 2018, there were 4 manufacturers and vaccines that successfully passed the pre-certification of vaccines in China, namely, Chengdu institution’s Yinao, Hualan’s Liugan, Kexing’s Miejia and Beishengyan’s bOPV. At the PQ consultation meeting in Beijing ...
- Source: drugdu
- 1,508
- August 25, 2021
China’s Import and Export Market Report of Contraceptive Drugs

Research by the World Health Organization has shown that“Physically, it is much more difficult to stop the production of millions of sperm per day for men than to prevent women from releasing an egg every month.” In the contraceptive drugs market, contraceptive drugs for women account for 90%, and is gradually becoming just as accepted in China as it is in most other parts of the world.
- Source: Ddu
- 47,398
- August 24, 2021
contraceptive drugs Ddu College
Medical registration for India —— What to do after the first official submission?

People who understand the process of medical registration for India would know that Indian registration is divided into two steps, which are Marketing Approval and Product Registration.You can find the details of the registration profile and flowchart from different countries we have prepared for you on Ddu (Drugdu.com). Ddu has listed the key points about what we need to do after the first official submission of Marketing Approval documents. 1. Wait for the official feedback, and follow the feedback to make the corresponding data revisions and supplements; 2. Get prepared for the plan of clinical Phase; You may have doubts while reading this point, why do we need to prepare a clinical plan during the first stage of registration, which is the Marketing Approval stage? First, the clinical Phase 3 study is a major premise for vaccine products to enter the Indian market; Secondly, the review ...
- Source: drugdu
- 962
- August 24, 2021
Ddu College：Pharmacovigilance

Pharmacovigilance,A discipline that collects, monitors, researches, and evaluates information about health care providers and patients regarding to the adverse drug reactions , biological products, herbs, and traditional medicine.
- Source: Ddu
- 2,099
- August 24, 2021
Special activity for the 5th Anniversary of Drugdu.com

Share Your Story with Drugdu (www.drugdu.com) Grand rewards of USD $800 in value are waiting for you! Activity period: August 12, 2021-August 31, 2021 Objects: All registered users of Drugdu Story Content: How did you make a successful trade on Drugdu? eg: experience of communication with your buyers and what did you learnt from it; how to follow up an inquiry; tactics of a successful communication; memories of how you made the deal, etc. How to operate a website/websites on Drugdu? eg: tips on how to reply an inquiry; analyses methods on potential buyers and inquiries; skills of developing more customers, etc. How is your cooperation with Drugdu? Manuscript Requirements: Original work, no limit of the style, no less than 800 words. When you submit the manuscript, please add a [The 5th Anniversary] in the subject of the mail, and your name and tel/phone number should be clarified. eg: ...
- Source: drugdu
- 264
- August 10, 2021
Newly introduced Health and Care Bill aims to ‘dispose of unnecessary bureaucracy’

Health and Social Care Secretary Sajid Javid has introduced a new Health and Care Bill to parliament this week, containing proposals to ‘help the NHS build back better from the pandemic’. Earlier this year, the government revealed its proposed plans for the new Bill, with the formal introduction to parliament coming on the heels of ‘extensive’ discussion with NHS England, the Local Government Association and the health and care sector. Among the key measures outlined in the Bill includes plans to bring together the NHS and local government to plan health and care services. Other proposals include the development of a new procurement regime for the NHS and public health procurement, which aims to reduce bureaucracy on commissioners and providers alike. This proposal will also aim to reduce the need for competitive tendering, when it adds limited or no value. The Bill will also ensure that each part of England ...
- Source: drugdu
- 204
- July 7, 2021
Health and Care Bill
Over 600,000 COVID-19 tests genomically sequenced in the UK

The UK has sequenced over 600,000 positive COVID-19 tests, providing ‘invaluable data’ in the fight against the virus, the Department of Health and Social Care (DHSC) announced last Friday. According the DHSC, the UK is estimated to contribute around 23% of all COVID-19 sequencing across the globe uploaded to GISAID. In the early stages of the pandemic, the COVID-19 Genomics UK (COG-UK) consortium was created to enable the delivery of large-scale and rapid whole-genome virus sequencing for local NHS centres and the government. The data collected by COG-UK has aided public health agencies in decision making for managing COVID-19 outbreaks and for informing vaccine development efforts. When sequenced, virus genome data can then be combined with clinical and epidemiological datasets to help inform UK public health interventions and policies. In a statement, the DHSC added that this information will also enable the evaluation of novel treatments and non-pharmacological interventions in ...
- Source: drugdu
- 192
- July 5, 2021
COVID-19 tests
Scientists identify link between genetic changes and rare childhood cancer rhabdomyosarcoma

Genetic changes may help to improve decision making for the treatment of the rare and aggressive form of childhood cancer rhabdomyosarcoma, according to a new international study led by researchers at the Institute of Cancer Research, London (ICR). The study analysed the DNA from 641 patients with rhabdomyosarcoma – a rare and aggressive type of childhood cancer that resembles muscle tissue and mostly affects children. According to ICR, less than 30% of children with this type of cancer who have relapsed and whose disease has spread will survive. There are two main subtypes of rhabdomyosarcoma, including fusion gene-positive and fusion gene-negative, depending on the presence of a ‘fusion gene’. Researchers found that, when looking at those with fusion-negative rhabdomyosarcoma, children whose tumours had faults in the genes MYOD1 and TP53 had significantly poorer response to treatment and worse survival outcomes. The TP53 gene was found to be altered in 69 ...
- Source: drugdu
- 171
- June 28, 2021
rhabdomyosarcoma

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