On December 20, 2024, WuXi Biologics announced that Nasdaq listed biotechnology company Aadi Biosciences had reached a cooperation agreement with WuXi Biologics and Duoxi Biologics to jointly develop three new generation ADC drugs in the preclinical stage, using WuXi Biologics’ antibody discovery technology platform and Duoxi Biologics’ linker payload technology. Aadi Biosciences paid a prepayment of $44 million, a development milestone of $265 million, a commercial milestone of $540 million, and a single digit sales share to WuXi Biologics and Duoxi Biologics, with a total agreement amount of $849 million. Affected by this news, the stock price of Aadi Biosciences surged 63% after trading. Aadi Biosciences had long focused on drug development in the mTOR pathway. Aadi Biosciences’ sirolimus albumin received FDA approval for marketing in 2021, with cumulative sales of $45 million in the first half of this year. As of the end of June this year, Aadi Biosciences ...
Novo Nordisk’s success has not only driven Denmark’s economic growth, but also led to an increasingly fierce talent war in the local labor market. As of September this year, the company employed about 32,000 employees across Denmark, and the number of employees has increased by 75% in less than three years. How exaggerated is Novo Nordisk’s talent war? Because Novo Nordisk offers higher salaries and more attractive career opportunities, many small businesses are forced to close or relocate because they cannot compete with it. For example, Flint Auto, a car service shop in Kalundborg, was forced to close because employees jumped to Novo Nordisk. Construction-related industries are facing a loss of talent, and many companies have to refuse orders due to lack of employees. The clinical microbiology department of a local hospital lost about 10 employees to Novo Nordisk in two years, and it was difficult to recruit new people. ...
Recently, AstraZeneca announced that the FDA rejected the full approval of its drug Andexxa. It is worth mentioning that the drug was applied for listing in China in December last year. In 2018, Andexxa was approved by the FDA for accelerated listing in the United States, and the following year it won conditional approval from the European Union for the treatment of acute bleeding complications caused by apixaban and rivaroxaban. It is the first and only treatment method that can specifically reverse the activity of FXa inhibitors and achieve hemostasis. It can be said to be a “life-saving drug” in clinical practice. In 2021, AstraZeneca acquired the rare disease giant Alexion for US$39 billion, and Andexxa became a drug under AstraZeneca. Last year, Andexxa contributed US$182 million in sales to AstraZeneca, a year-on-year increase of 23%. In its reply letter, the FDA pointed out that the rejection was because the ...
On December 18, Eli Lilly announced that the application for the listing of Donanemab injection (Donanemab) has been approved by the China National Medical Products Administration for the treatment of mild cognitive impairment and mild dementia caused by Alzheimer’s disease in adults. This is another blockbuster new drug in the field of Alzheimer’s disease (AD) treatment after Lencanerizumab, which was approved by Eisai in January this year. In the past, drugs for the treatment of AD were mainly symptomatic treatments, including memantine, donepezil, etc., which symptomatically treated mild, moderate and severe AD. Lencanerizumab and Donanemab, which were launched this year, are targeted treatments for causes. ▍Crossing the Death Valley of Drug Development The research on new drugs for Alzheimer’s disease has always been called the “Death Valley” of drug development. According to a study published by Scientific American magazine, the development of new AD drugs has a high failure rate ...
The journal Nature Reviews Drug Discovery published the prediction of the top 10 global best-selling drugs in 2025. Pembrolizumab, commonly known as “K drug”, topped the list, followed by semaglutide, which has been popular in the field of weight loss in recent years, and its “rival” dual-target telpotide, which is consistent with the sales performance of these drugs in the first three quarters of this year. Among the top ten lists, 4 GLP-1 products entered the forecast list, all of which belong to the field of metabolic therapy. In addition, Dupixent (dupixentumab) and Skyrizi (lishengqizumab), two autoimmune drugs that are frequent guests on the best-selling drug list, are still on the list, ranking 4th and 5th. ▍With a wide range of indications, “K drug” is expected to become the “king of medicine” again In the 2025 forecast, “K drug” still ranks first. In 2023, the global sales of K drug ...
Reducing RSV-related hospitalization rates by more than 80%, FDA accepts Merck’s long-acting antibody therapy marketing application Merck (MSD) announced today that the U.S. FDA has accepted the company’s biologics license application (BLA) for the investigational preventive long-acting monoclonal antibody clesrovimab (MK-1654), which is designed to protect infants from RSV disease during their first respiratory syncytial virus (RSV) season. The FDA is scheduled to complete the review by June 10, 2025. Clesrovimab is an extended half-life monoclonal antibody under investigation for the prevention of RSV disease as a passive immunization method. The application is based on the results of the pivotal Phase 2b/3 clinical trial CLEVER, a randomized, placebo-controlled trial evaluating the effect of a single dose of clesrovimab in healthy premature and full-term infants; and interim results of the ongoing Phase 3 clinical trial SMART, which evaluates the safety and efficacy of clesrovimab compared with palivizumab in high-risk infants and ...
On the evening of December 16, Kangchen Pharmaceuticals issued an announcement. First, it will make an impairment provision for the goodwill formed by the acquisition of Tailing International’s equity; second, the “Annual Production of 500kg Anti-tumor API Production Base Construction Project” (hereinafter referred to as the “API Project”) is expected to be extended to December 2026. At the opening of December 17, Kangchen Pharmaceuticals’ stock price fell by more than 2%. As of the close, Kangchen Pharmaceuticals reported 25.9 yuan/share, down 3.61%, and the current market value is 4.144 billion yuan. In fact, Kangchen Pharmaceuticals has acquired Tailing International’s equity for four years. In April 2020, Kangchen Pharmaceuticals acquired 100% of Tailing International’s equity by paying 900 million yuan in cash, thereby obtaining the “Migaix” business. After acquiring Tailing International, Kangchen Pharmaceuticals has conducted impairment tests on the goodwill formed every year. As of now, the company has not made ...
According to Xinhua News Agency, Tianjin (reporters Zhang Jianxin and Bai Jiali), on December 16, Tianjin issued the first wholly foreign-owned tertiary general hospital medical institution practice license, and Perennial General Hospital (Tianjin Perennial Hospital) became the first wholly foreign-owned tertiary general hospital in my country. At the end of November this year, the National Health Commission, the Ministry of Commerce, the State Administration of Traditional Chinese Medicine, and the National Center for Disease Control and Prevention announced the “Pilot Work Plan for Expanding the Opening of Wholly Foreign-Owned Hospitals”. Previously, relevant departments have proposed to allow the establishment of wholly foreign-owned hospitals in Beijing, Tianjin, Shanghai and other places (except for traditional Chinese medicine, excluding mergers and acquisitions of public hospitals). Tianjin Perennial Hospital was invested and built by Singapore Perennial Group with a total investment of approximately RMB 1 billion and 500 beds. It not only has special ...
Ocaliva (obeticholic acid), which started as a blockbuster liver disease therapy and attracted much attention for its great potential in MASH treatment, will further fade away at the end of 2024. Not only did the “bad” news come one after another, but it also came from the two regulatory agencies covering the European and American markets, the FDA and the EMA. However, looking back at the development history of obeticholic acid, it is actually not smooth. Since it was approved for the treatment of primary cholangitis (PBC) in 2016, Intercept has tried twice to expand the drug to MASH, but both attempts failed. This made Intercept completely abandon the MASH project and lay off one-third of its employees. Later, Intercept was acquired by the Italian pharmaceutical company Alfasigma, but the change of destination did not improve the fate of obeticholic acid. And with the first PPAR agonist Elafibranor approved by ...
Yingtai Medical (01501. HK) recently announced that the company has signed a letter of intent to acquire its target company Hangzhou Weiqiang Medical Technology Co., Ltd. and its affiliated group companies on December 18, 2024. According to the terms of the agreement, Yingtai Medical plans to acquire at least 51% of the controlling stake in Weiqiang Medical through capital increase, share expansion, and acquisition of shares from some shareholders. This transaction also stipulates that Yingtai Medical will inject no less than RMB 200 million in new funds into Weiqiang Medical after the acquisition is completed, and must pay a prepayment of RMB 30 million after the agreement takes effect. Weiqiang Medical has attracted much attention for its outstanding product development and clinical integration capabilities. In its product line, it includes Professor Guo Wei’s WeFlow Branch split type thoracic aortic stent graft from 301 Hospital, and Professor Fu Weiguo’s Fabulous stent ...
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