PharmaFocus Today – Page 15 – media

Patient dies in Pfizer hemophilia drug trial, company issues statement

On December 23 local time, Pfizer Inc. announced that a patient participating in a long-term study of its hemophilia drug had died following severe side effects. Pfizer’s stock closed down more than 1% on the same day. According to the European Haemophilia Consortium, a patient support organization, the patient died on December 14 from a brain hemorrhage following a stroke. The long-term study involved Pfizer’s long-acting hemophilia therapy, Hympavzi. The drug, administered via weekly injections, was approved in the United States last year for the treatment of patients aged 12 and older with hemophilia A or B. It works by targeting specific clotting proteins to prevent or reduce bleeding episodes. Regarding the fatality, Pfizer responded in a statement: “Pfizer, along with trial investigators and an independent external Data Monitoring Committee, is actively gathering information to better understand the complex and multifactorial circumstances surrounding this event.” The company further stated that, ...
- Source: drugdu
- 63
- December 25, 2025
Sanofi to Acquire Dynavax for $2.2 Billion, Strengthening Vaccine Business Portfolio

French pharmaceutical giant Sanofi announced on Wednesday that it will acquire U.S. vaccine company Dynavax Technologies for approximately $2.2 billion (€1.9 billion) in cash. This deal will grant Sanofi access to an approved hepatitis B vaccine. Following the news, Dynavax’s stock surged nearly 40% in early U.S. trading. This year, Sanofi has completed several acquisitions aimed at reducing its reliance on the blockbuster asthma drug Dupixent and diversifying its business. In July, the company acquired British private biotech firm Vicebio for $1.5 billion, shortly after finalizing its acquisition of U.S. rare disease drugmaker BluePrint Medicines, a deal valued at up to $9.5 billion. Under the terms of the agreement, Sanofi will acquire Dynavax for $15.50 per share in cash, representing a 39% premium over its closing price of $11.13 on Tuesday. Sanofi stated that it expects the acquisition to be completed in the first quarter of 2026, with payment to ...
- Source: drugdu
- 53
- December 25, 2025
Over $2 billion! Another major deal for a domestically developed innovative drug

Today, Tongyi Pharmaceuticals announced that it has entered into an exclusive licensing agreement with MultiValent for CBP-1018, a peptide-drug conjugate for the treatment of prostate cancer . Under the terms of the agreement, MultiValent will obtain exclusive rights to develop and commercialize CBP-1018 in markets outside of Greater China. Tongyi Pharmaceuticals will receive an upfront payment of US$20 million, a 20% equity stake in MultiValent, and up to approximately US$2 billion in future payments for development, regulatory, and commercial milestones, as well as tiered sales royalties. CBP-1018 is a bispecific peptide drug developed by Yimei Pharmaceuticals based on its proprietary Bi-XDC (bispecific dual-ligand conjugate) platform. It is conjugated with Auristatin-E and targets two proteins highly expressed in prostate cancer cells: PSMA and FRα . In a phase I/II clinical trial involving more than 110 patients with metastatic castration-resistant prostate cancer, intravenous CBP-1018 demonstrated encouraging preliminary safety and efficacy. A median ...
- Source: drugdu
- 63
- December 24, 2025
Good news for middle-aged and elderly men! Taincon has become the first generic version of a compound drug for benign prostatic hyperplasia

Recently, according to information published on the official website of the National Medical Products Administration (NMPA), Shandong Huabo Kaisheng Biotechnology, a wholly-owned subsidiary of Guangdong Taienkang, has received approval for the marketing of finasteride tadalafil capsules (trade name: Aitinglie® ) , successfully becoming the first generic version of this drug in China. The original drug was developed by VERU in the United States and approved there in 2021. This domestic production fills a market gap for compound treatment drugs for benign prostatic hyperplasia in China . The unique feature of finasteride tadalafil capsules lies in the synergistic effect of its dual mechanisms of action . • Finasteride, as a type II 5α-reductase inhibitor, can inhibit benign prostatic hyperplasia at its source by reducing the gland size by lowering dihydrotestosterone levels; • Tadalafil, as a PDE5 inhibitor, quickly relieves urinary difficulties by relaxing smooth muscles. This combination achieves both symptomatic and ...
- Source: drugdu
- 58
- December 24, 2025
BeiGene – Catadegbrutinib Initiates International Multicenter Phase II Clinical Trial for B-Cell Leukemia

On December 23, 2025, BeiGene announced the initiation of a global, multicenter Phase II clinical trial of catadegbrutinib (BTK, PROTAC) for B-cell hematologic malignancies. The trial, designated CTR20254960, is titled “Evaluating BGB-16673, a Bruton’s tyrosine kinase-targeting protein degrader, in a Phase 1/2, open-label, dose-escalation and expansion study for the treatment of patients with B-cell malignancies.” This international, multicenter clinical trial plans to enroll 730 participants. The investigational drug in this clinical trial is catadegbrutinib. The primary endpoint was the major response rate (MRR) in stage II. The domestic lead institution is Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, and the principal investigator is Professor Li Jian. https://bydrug.pharmcube.com/news/detail/55a4c0369a540aa555859fb702eea4f7
- Source: drugdu
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- December 24, 2025
IND for Oral Small-Molecule KRAS G12D Inhibitor ABSK141 Approved by NMPA

On the morning of December 24, Abbisko Therapeutics announced on the Hong Kong Stock Exchange that its subsidiary, Shanghai Abbisko Biotechnology Co., Ltd., has received approval from the National Medical Products Administration (NMPA) of China for the Investigational New Drug (IND) application of its oral, highly potent, and selective small-molecule KRAS G12D inhibitor ABSK141. The drug is intended for the treatment of patients with advanced solid tumors harboring the KRAS G12D mutation. Reference：https://finance.eastmoney.com/a/202512243600135972.html
- Source: drugdu
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- December 24, 2025
Wantai Bio’s bivalent HPV vaccine (Escherichia coli) was shortlisted for the National Immunization Program (NIP)

Beijing Business Today — On the evening of December 22, Wantai Bio (603392.SH) announced that its wholly-owned subsidiary, Xiamen Innovax Biotech Co., Ltd., participated in the bidding for the 2025 National Immunization Program (NIP) Vaccine Centralized Procurement Project—specifically for the Bivalent Human Papillomavirus (HPV) Vaccine. The company’s Bivalent HPV Vaccine (E. coli) has been shortlisted with a unit price of 27.5 RMB. Wantai Bio stated that this centralized procurement is organized by the Chinese Center for Disease Control and Prevention (China CDC). If the company subsequently signs the procurement contract and organizes production and supply, it will help expand the sales volume of the shortlisted product, increase its market share, promote domestic market development, and enhance the company’s brand influence. https://finance.eastmoney.com/a/202512223598332095.html
- Source: drugdu
- 52
- December 24, 2025
Subsidiary Receives Clinical Trial Approval for Daratumumab Injection

China Securities Intelligent Financial News — CSPC NovaWise (300765.SZ) announced on the evening of December 23 that its majority-owned subsidiary, CSPC Megalith Biopharmaceutical Co., Ltd., recently received the “Drug Clinical Trial Approval Notice” issued by the National Medical Products Administration (NMPA) for its Daratumumab Injection. The drug will commence domestic clinical trials in the near future. According to the announcement, the injection is a recombinant all-human IgG1 monoclonal antibody targeting ADP-ribosyl cyclase (CD38). As a biosimilar to the originator drug DARZALEX®, it was filed under Category 3.3 for therapeutic biological products and is indicated for the treatment of adult patients with multiple myeloma. The development of this product follows the guiding principles for biosimilar research. Results from pharmaceutical and non-clinical studies demonstrate that the product is highly similar to the reference originator drug in terms of quality, safety, and efficacy, supporting the progression to subsequent clinical studies. Public records show ...
- Source: drugdu
- 62
- December 24, 2025
Walvax Bio’s subsidiary’s HPV vaccine selected for national centralized procurement

On December 23, Walvax Bio(300142) issued an announcement stating that its subsidiary participated in the National Immunization Program’s centralized procurement project for vaccines and successfully entered the shortlist. The announcement shows that Yuxi Zerun Biotechnology Co., Ltd.’s bivalent human papillomavirus vaccine (Pichia pastoris) was shortlisted for the project, with a shortlisted unit price of 27.5 yuan. This vaccine is primarily used to prevent diseases caused by high-risk HPV types 16 and 18, including cervical cancer. It was launched in China in 2022 and received prequalification from the World Health Organization in August 2024. This inclusion in the list will help expand the company’s sales of its bivalent HPV vaccine, increase market coverage, promote the market development of related products, and enhance brand influence. However, the announcement also pointed out that since only two companies were shortlisted, further negotiations with various provinces are needed, and the implementation period for vaccination is relatively ...
- Source: drugdu
- 67
- December 24, 2025
Jacobio secured the largest licensing deal for a clinical-stage small molecule anticancer drug, yet its stock price plummeted by over 13%. The chairman responded

“US$2.015 billion is, according to our statistics, the largest overseas licensing collaboration for small molecule anticancer drugs in the clinical stage in China.” On the morning of December 22, Jacobio (HK01167) held an online communication meeting regarding its newly announced business development (BD) efforts surrounding the pan-KRAS inhibitor JAB-23E73. Simultaneously, the company’s stock price fell by over 10%, closing down 13.58%. Both the transaction amount and AstraZeneca’s position in the oncology drug field have generated considerable excitement among investors who saw the news of the collaboration the night before. Moreover, this is Jacobio’s first business development (BD) deal announced this year. Was the secondary market’s reaction unexpected? At the communication meeting, Wang Yinxiang, Chairman of Jacobio, responded to this question from a reporter from the Daily Economic News. He said that as a biotech company, Jacobio pays attention to the secondary market, but it cannot be “led by the crowd” ...
- Source: drugdu
- 53
- December 24, 2025

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