Have you gone out and left the television on? Have you ever forgot to buy the item for which you went shopping for? These are examples of prospective memory failure, which could be an early sign of Alzheimer's disease.
The condition of memory loss is termed as Alzheimer’s disease, affecting more than 5 million people and there is still no definite cure. A research team reported that an experimental drug could treat Alzheimer’s disease by slowing down the process of clear thinking and memory.
Risk of Alzheimer's disease increases with reduction in levels of plasmalogens, a class of lipids produced by the liver that constitute cell membranes in the brain, confirms new research presented at the Alzheimer's Association International Conference (AAIC) 2018 by Mitchel A. Kling, MD, an associate professor of Psychiatry in the Perelman School of Medicine at the University of Pennsylvania and the Veterans Affairs Medical Center.
Glaucoma is an eye disorder causing irreversible blindness and affects around 60 million people throughout the world. This condition leads to the loss of retinal ganglion cells, located near the surface of the retina. The prime focus of glaucoma research is to put an end to the loss of these cells in the initial stages.
A research team from Tel Aviv University suggested that red wine and green tea could treat certain congenital metabolic diseases, by blocking toxic metabolite formations. Since people with inborn metabolic disorders are born with a defective gene, it leads to a critical enzyme deficiency. Since there is no cure, many patients with congenital metabolic disorders are required to follow a lifelong strict diet.
In a research study led by Yuksel Agca, associate professor of veterinary pathology and a researcher in the Comparative Medicine Program in the MU College of Veterinary Medicine, it was found that two proteins namely APP and PS1, were the key factors linked to Alzheimer’s disorder, by carrying out the research work in rat model. If the accumulation of amyloid-β could be manipulated, it could lead to a decrease in the onset of Alzheimer Disease.
No longer science fiction, a "prosthetic memory" neural implant can actually improve short term memories.
One of the first studies to explore the effects of calorie restriction on humans showed that cutting caloric intake by 15% for 2 years slowed aging and metabolism and protected against age-related disease. The study, which will appear March 22 in the journal Cell Metabolism, found that calorie restriction decreased systemic oxidative stress, which has been tied to age-related neurological conditions such as Alzheimer's and Parkinson's diseases, as well as cancer, diabetes, and others.
Denali Therapeutics Inc. (NASDAQ:DNLI), a biopharmaceutical company developing a broad portfolio of therapeutic candidates for neurodegenerative diseases, today announced that it has commenced dosing of its small molecule inhibitor of RIPK1 in a Phase 1 clinical trial in healthy volunteers and achieved proof of concept of its large molecule blood-brain barrier delivery platform technology in nonhuman primates.
Sangamo Therapeutics, Inc. and Pfizer Inc. announced a collaboration for the development of a potential gene therapy using zinc finger protein transcription factors to treat amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to mutations of the C9ORF72 gene.
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