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Natural products and herbal medicines show promise in fight against COVID-19

Researchers in China and the United States have called for more research into the potential prophylactic effects of natural products and herbal medicines on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent coronavirus disease 2019 (COVID-19). In an article recently published in the journal Frontiers in Pharmacology, the team discussed natural products that have exhibited an inhibitory effect on SARS-CoV-2 and herbal medicines that have been tested as potential therapies for COVID-19. “In this review, we aimed to provide a new perspective regarding COVID-19 prevention,” writes Jia-xu Chen from Jinan University in Guangzhou, and colleagues from the University of Houston, and the University of California. The researchers suggest that while the world awaits effective treatments and a commercially available vaccine, the repurposing of natural products and herbal medicines as prophylactics represents a promising approach to at least slow the transmission of SARS-CoV-2. “In the interest of public health, this ...
- Source: drugdu
- 1,343
- November 18, 2020
Covid-19
Moderna expects to know by the end of the month whether its Covid-19 vaccine works

By Elizabeth Cohen and Lauren Mascarenhas, CNN Updated 0510 GMT (1310 HKT) November 12, 2020 Fauci says vaccine could be available to all by April 02:52 (CNN)Moderna has finished accumulating data for a first analysis of its Covid-19 vaccine and expects to have an announcement on the vaccine’s efficacy by the end of the month, the company said in a statement Wednesday. Pfizer announced Monday that its coronavirus vaccine is more than 90% effective. Moderna is conducting a clinical trial of 30,000 participants, with half receiving the vaccine and half receiving a placebo, which is a shot of saline that does nothing. In order for Moderna’s vaccine to be considered for authorization by the US Food and Drug Administration, at least 53 study participants needed to become ill with Covid-19. The trial hit that 53 mark Wednesday, but Moderna doesn’t know if the participants who became ill received the vaccine or the ...
- Source: drugdu
- 350
- November 17, 2020
Covid-19
Poor nutrition in school years may have created 20 cm height gap across nations

A new global analysis led by Imperial College London, and published in journal The Lancet, has assessed the height and weight of school-aged children and adolescents across the world. The study, which used data from 65 million children aged five to 19 years old in 193 countries, revealed that school-aged children’s height and weight, which are indicators of their health and quality of their diet, vary enormously around the world. There was a 20 cm difference between 19-year-olds in the tallest and shortest nations — this represented an eight-year growth gap for girls, and a six-year growth gap for boys. For instance, the study revealed that the average 19-year-old girl in Bangladesh and Guatemala (the nations with the world’s shortest girls) is the same height as an average 11-year-old girl in the Netherlands, the nation with the tallest boys and girls. The international team behind the study warn that highly variable ...
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- 290
- November 16, 2020
height nutrition
Second wave of COVID-19 in UK has reached “critical” stage, says study

Caused by the highly contagious pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the feared but expected the second wave of coronavirus disease 2019 (COVID-19) has already hit the UK. This can be seen in the current high prevalence of infection across the country. Thus, the virus is poised to take a high toll on the country’s public health – and ultimately many of its citizen’s lives – unless prompt containment measures are put in place, says a recent study published on the preprint server medRxiv.* The first wave of the pandemic in the UK occurred from March and April 2020, characterized by a high infection peak and then a steep and continuing decline in new infections that lasted until the beginning of August. From this point on, there has been a steady rise in infections, with the reproduction number (R) staying above 1, indicating a propagating epidemic. Increasing Prevalence ...
- Source: drugdu
- 198
- November 15, 2020
Covid-19
Discovery of novel hidden gene in SARS-CoV-2

Understanding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the virus that causes the coronavirus disease 2019 (COVID-19) – is crucial for both vaccine and treatment development. Since the pandemic started in December 2019, many studies have explored the virus’s origins and how it infects humans. This way, scientists and clinicians have an idea of how to combat the infection. A team of researchers from Germany, Taiwan, and the United States has identified and characterized a new hidden gene in SARS-CoV-2 that is also present in Guangxi pangolin coronaviruses – though, curiously, absent in closely related pangolin and bat coronaviruses. What are overlapping genes? The coronavirus pandemic raises urgent questions about the properties that allow viruses in animals to jump to humans. Called zoonosis, these types of diseases have impacted human life for years, including the AH1N1 virus, bovine tuberculosis, glanders, and bubonic plague, among others. To further understand zoonotic diseases, ...
- Source: drugdu
- 286
- November 14, 2020
Covid
Severe COVID-19 linked to age, body mass index and ABO blood group

With the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecting over 50 million people worldwide with hundreds of thousands experiencing severe respiratory illness, researchers have been trying to find the factors associated with severe disease. From the start of the pandemic in March this year, several studies have indicated heart disease, high blood pressure, diabetes, obesity, etc. could be linked to severe disease. Now German researchers have published a study on the association between severe respiratory infection caused by SARS CoV-2 and factors such as age, body mass index (BMI) and ABO blood group. Their study titled, “Severity of Respiratory Infections due to SARS-CoV-2 in Working Population: Age and Body Mass Index Outweigh ABO Blood Group,” was released prior to peer review on the preprint site medRxiv*. Background There is a rise in cases of COVID-19, and there is a lack of consensus regarding the high-risk ...
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- 125
- November 13, 2020
Covid-19
Spain’s annual life expectancy at birth dropped due to COVID-19 pandemic

Spain’s annual life expectancy at birth dropped by 0.9 years between 2019 and the annual period up until July 2020 due to the COVID-19 pandemic, according to a new study published this week in the open-access journal PLOS ONE by Sergi Trias-Llimos of the Center for Demographic Studies, Spain, and colleagues. The COVID-19 pandemic is causing substantial increases in mortality in populations worldwide, and Spain was one of the most affected countries in the spring of 2020. Life expectancy is an easy to interpret, standard indicator in mortality patterns. However, few studies assessing the impact of the pandemic on mortality to date have reported life expectancy estimates. In the new study, researchers used daily death count data from the Spanish Daily Mortality Monitoring System (MoMo) as well as information on death, population and demographic information from the Spanish National Statistics Institute. The team estimated weekly and annual life expectancies at birth for ...
- Source: drugdu
- 349
- November 12, 2020
Covid-19
Anvisa suspende temporariamente teste da vacina CoronaVac, que será produzida pelo Butantan

Interrupção foi determinada após ‘evento adverso grave’, segundo a agência. Em entrevista à TV Cultura, diretor do Butantan disse que a morte do voluntário não teve relação com o teste. A Agência Nacional de Vigilância Sanitária (Anvisa) suspendeu temporariamente os testes em humanos da vacina CoronaVac contra a Covid-19. De acordo com a agência, a interrupção foi determinada nesta segunda-feira (9) por causa de um “evento adverso grave”, mas não deu detalhes sobre a causa específica da suspensão. A Anvisa informou que foi notificada do “evento” em 29 de outubro. Mais de 10 dias depois, determinou que nenhum novo voluntário poderá ser vacinado até que a agência possa avaliar os dados e “julgar o risco/benefício da continuidade do estudo”. Segundo uma lista divulgada pela agência, são considerados eventos adversos graves “morte, evento adverso potencialmente fatal, incapacidade ou invalidez persistente, internação hospitalar do paciente, anomalia congênita ou defeito de nascimento, qualquer suspeita de transmissão ...
- Source: drugdu
- 399
- November 11, 2020
Covid-19 vaccine
PFIZER AND BIONTECH ANNOUNCE VACCINE CANDIDATE AGAINST COVID-19 ACHIEVED SUCCESS IN FIRST INTERIM ANALYSIS FROM PHASE 3 STUDY

Monday, November 09, 2020 – 06:45am Vaccine candidate was found to be more than 90% effective in preventing COVID-19 in participants without evidence of prior SARS-CoV-2 infection in the first interim efficacy analysis Analysis evaluated 94 confirmed cases of COVID-19 in trial participants Study enrolled 43,538 participants, with 42% having diverse backgrounds, and no serious safety concerns have been observed; Safety and additional efficacy data continue to be collected Submission for Emergency Use Authorization (EUA) to the U.S. Food and Drug Administration (FDA) planned for soon after the required safety milestone is achieved, which is currently expected to occur in the third week of November Clinical trial to continue through to final analysis at 164 confirmed cases in order to collect further data and characterize the vaccine candidate’s performance against other study endpoints This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201109005539/en/ NEW YORK & MAINZ, GERMANY–(BUSINESS WIRE)– Pfizer Inc. (NYSE: ...
- Source: drugdu
- 1,240
- November 10, 2020
Covid-19 Pfizer
FDA warns of COVID-19 antigen test false positives as report flags Quidel on accuracy

FDA has issued an alert to clinical labs and healthcare providers about the potential for COVID-19 antigen tests to deliver false positives after receiving reports from nursing homes and other settings. The agency’s Tuesday notice reminds users to follow the instructions, noting that improper storage and reading the results at the wrong time can lead to false results. At the same time, the agency said false positives could be an inevitable consequence of using tests with specificities below 100%. If a test with 98% specificity is used to screen a population in which 10% of people are infected, two out of every 10 positive results will be false. The FDA’s warning comes a day after The New York Times reported on a University of Arizona study raising concerns about the ability of a Quidel rapid antigen test to detect asymptomatic cases. The study found Quidel’s test produced more false positives than positives confirmed by the gold standard PCR tests. The potential for antigen tests ...
- Source: drugdu
- 392
- November 9, 2020
Covid-19

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