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Molecular component of caffeine may play a role in gut health

Brigham researchers studying how and why certain cell types proliferate in the gut found that xanthine, which is found in coffee, tea and chocolate, may play a role in Th17 differentiation. Insights may help investigators better understand gut health and the development of conditions such as inflammatory bowel disease. The gut is home to a cast of microbes that influence health and disease. Some types of microorganisms are thought to contribute to the development of inflammatory conditions, such as inflammatory bowel disease (IBD), but the exact cascade of events that leads from microbes to immune cells to disease remains mysterious. A new study by investigators from Brigham and Women’s Hospital explores exactly what leads to the generation of Th17 cells—an important subtype of cells in the intestine—and uncovers some of the underappreciated molecular players and events that lead to cell differentiation in the gut. One of those players is the purine metabolite xanthine, which is found ...
- Source: drugdu
- 263
- March 15, 2023
Study finds COVID-19 pandemic has long-lasting effects on adolescent mental health and substance use

The COVID-19 pandemic has had a long-lasting impact on adolescent mental health and substance use, according to a new population-based study based on survey responses from a nationwide sample of over 64,000 13–18-year-old North American and Icelandic adolescents assessed prior to and up to two years into the pandemic. The study was conducted by faculty at Columbia University Teachers College and Mailman School of Public Health and a team of Icelandic and other North American clinical, behavioral and social scientists. The findings are published in published in The Lancet Child & Adolescent Health. This same research team published a population-based study in The Lancet Psychiatry in 2021 showing an increase in depressive symptoms and decrease in mental well-being among 13–18-year-old adolescents within one year of the global spread of the COVID-19 pandemic. A decline in substance use, in particular cigarette smoking, e-cigarette use and alcohol intoxication, was also observed. Expanding on these findings, this new study shows ...
- Source: drugdu
- 115
- March 15, 2023
An overview of COVID-19-associated neurological complications in children

In a recent study posted to the Research Square* preprint server, an international team of researchers review current literature to understand the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, abnormal neuroimaging manifestations, and neurological symptoms among individuals under the age of 18. Background The clinical presentation of the coronavirus disease 2019 (COVID-19) varies widely across individuals, ranging from asymptomatic or mild to severe cases involving acute respiratory distress syndrome (ARDS), pneumonia, and multi-organ complications. Emerging evidence suggests that the thrombogenic reactions and cytokine storm that develop during acute COVID-19 contribute to psychiatric and neurological complications, with a high incidence of intracerebral hemorrhage and ischemic stroke. While many studies have investigated the neurological complications associated with acute SARS-CoV-2 infections among adults, COVID-19 manifestations among children have largely been asymptomatic or mildly symptomatic and not require hospitalization. However, emerging evidence indicates that systemic symptoms such as secondary inflammatory responses, which are collectively known ...
- Source: drugdu
- 298
- March 15, 2023
Siemens and Sysmex Sign Global Hemostasis Supply Agreement

Image: Sysmex and Siemens have established global agreement to supply hemostasis instruments and reagents as OEMs (Photo courtesy of Sysmex) Sysmex Corporation (Kobe, Japan) and Siemens Healthcare Diagnostics Inc. (Siemens Healthineers, Erlangen, Germany) have signed a global OEM agreement on hemostasis products under which each company will supply the other with their products in the diagnostic field of hemostasis on an OEM basis. Both Siemens and Sysmex provide hemostasis products used in testing for blood clotting disorders, preoperative bleeding risk management, and the monitoring of patients receiving anticoagulant therapy medications. Following their global agreement on distribution, sales, and services for hemostasis products signed in 1995, the two companies have since then developed a strong partnership and gone on to become one of the leading solution providers in the global hemostasis space. Over this period, the companies have further expanded their capabilities and gained strength by introducing new innovations in ...
- Source: drugdu
- 232
- March 15, 2023
Websites and Tools You Need to Know!

The pharmaceutical foreign trade industry is fiercely competitive, demanding a constant grasp of the latest market information and tech tools to successfully expand business. Today, we're showcasing must-have websites and practical tools for pharmaceutical foreign trade professionals, empowering you to operate more efficiently.
- Source: drugdu
- 237
- March 3, 2023
pharmaceutical foreign trade practical tools
Why Small Biotech Needs To Plan Ahead For Global Reach

If small biotech does more to plan ahead for ex-US market requirements, companies and their investors – and crucially patients – will benefit.
- Source: https://invivo.pharmaintelligence.informa.com/IV124998/Missed-Opportunities-Why-Small-Biotech-Needs-To-Plan-Ahead-For-Global-Reach
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- April 6, 2022
biotech commercializing
Prioritize, Optimize And Modernize

Medtech’s resilience and flexibility have been clear to see during the COVID-19 pandemic. In this forward-looking view for 2022, CEOs from some of the Top 50 global medtechs share their perspectives on the present and the future, from company and health care system standpoints.
- Source: https://invivo.pharmaintelligence.informa.com/IV124946/The-PostCOVID-Mantra-For-Medtechs-Prioritize-Optimize-And-Modernize
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- April 6, 2022
Health Care Transformation Modernize Post-COVID Mantra
Explanatory AI system enables more accurate diagnosis of fetal congenital heart disease

Researchers from the RIKEN Center for Advanced Intelligence Project (AIP) and colleagues have tested AI-enhanced diagnosis of fetal congenital heart disease in a clinical setting. Both hospital residents and fellows made more accurate diagnoses when they used a graphical interface that represented the AI's analysis of fetal cardiac ultrasound screening videos. The new system could help train doctors as well as assist in diagnoses when specialists are unavailable. The report recently appeared in the scientific journal Biomedicines.
- Source: https://www.news-medical.net/news/20220405/Explanatory-AI-system-enables-more-accurate-diagnosis-of-fetal-congenital-heart-disease.aspx
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- April 6, 2022
Artificial Intelligence Cardiac Ultrasound heart disease
What Mutations of SARS-CoV-2 are Causing Concern?

As viruses are exposed to environmental selection pressures, they mutate and evolve, generating variants that may possess enhanced virulence. Some of the primary concerns that public health officials have as these new variants continue to emerge include their viral transmissibility, reinfection rates, disease severity, and vaccine effectiveness. SARS-CoV-2. Image Credit: ImageFlow/Shutterstock.com How do RNA viruses mutate? The mutation rate of single-stranded ribonucleic acid (ssRNA) viruses is observed to be much higher than organisms that possess single-stranded deoxyribonucleic acid (ssDNA), and many times more than those with double-stranded DNA (dsDNA). Not all mutations necessarily increase virulence and, in the majority of cases, may in fact be deleterious or inconsequential. Therefore, organisms must find an equilibrium between a high mutation rate that allows them to adapt to changing environmental conditions, and a low one that lessens the incidence of catastrophic mutations. Small DNA viruses may encode their own DNA repair, and ...
- Source: https://www.news-medical.net/health/What-Mutations-of-SARS-CoV-2-are-Causing-Concern.aspx
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- April 5, 2022
SARS-CoV-2 viruse
MEDICAL FAIR INDIA

MEDICAL FAIR INDIA 2022 is organized by Messe Dusseldorf, a German exhibition company. With 20 years of experience in the Indian Medical market, Medical Fair India has become the unique brand Medical Fair in India. This international fair has grown into a demand for the medical needs of India's more than 1.3 billion population. The Indian Medical Fair is a continuing success for exhibitors and visitors from all over the world.
- Source: drugdu
- 1,606
- March 31, 2022
MEDICAL FAIR INDIA

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