PharmaFocus Today – Page 39 – media

Growth of United Imaging Healthcare has Slowed Down, Leading to a Continuous Decline in its Stock Price

Recently, Shanghai United Imaging Healthcare Co., Ltd. (also known as, United Imaging Healthcare) released its 2024 semi annual report, with a revenue of 5.333 billion yuan in the first half of the year, a year-on-year increase of 1.18%; Realize a net profit attributable to the parent company of 950 million yuan, a year-on-year increase of 1.33%; Deducting non attributable net profit of 798 million yuan, a year-on-year increase of 1.39%. The growth of Zhonglian Film Medical has slowed down in the semi annual report, leading to a continuous decline in its stock price. Now that the market value of United Imaging Healthcare is not guaranteed at billions, how can the new rich break through the situation? CT business is sluggish, with a market value of billions falling Founded in 2011, United Imaging Healthcare is committed to providing global customers with a full range of independently developed high-performance medical imaging diagnosis ...
- Source: drugdu
- 85
- September 5, 2024
JCI | Zhu Yingjie’s team from Shenzhen Advanced Institute reveals a new central target of GLP-1R agonist, a “weight loss drug”

Obesity, as one of the top ten chronic diseases worldwide, has a research history of over a century in the field of weight loss drugs. After 2014, glucagon like peptide-1 (GLP-1) receptor agonists emerged as a new force, far surpassing other weight loss drugs in terms of efficacy and safety, and also driving the development and marketing of weight loss drugs. GLP-1, as an intestinal insulinotropic hormone, is generated by the post-translational cleavage of pre glucagon encoded by the pre glucagon gene (GCG). It is mainly secreted by intestinal L cells and a portion of neurons in the solitary tract nucleus (NTS) of the brainstem. The action of GLP-1 is mediated by the GLP-1 receptor (GLP-1 R) and is widely distributed in the peripheral and central nervous systems. Liraglutide is a short acting GLP-1 receptor agonist that acts on the central nervous system to reduce appetite and slow gastric emptying. ...
- Source: drugdu
- 99
- September 5, 2024
The Lancet reports that semaglutide has the potential to be used in heart failure patients

Recently, The Lancet published a new centralized, participant level analysis of heart failure patients with mild reduced ejection fraction or preserved ejection fraction (HFpEF) from four randomized placebo-controlled trials (2.4 mg for SELECT, STEP-HFpEF, STEP-HFpEF DM; 1.0 mg/d). picture According to analysis, semaglutide reduced the composite risk of cardiovascular (CV) death or worsening heart failure (HF) events by 31%, with incidence rates of 5.4% in the semaglutide group and 7.5% in the placebo group (HR 0.69; 95% CI 0.53-0.89; P=0.0045). semaglutide also reduced the risk of HF worsening by 41% (2.8% vs. placebo 4.7%; HR 0.59 (95% CI 0.41-0.82), p=0.0019). Simeglutide had no significant effect on the incidence of CV mortality (3.1% in the Simeglutide group and 3.7% in the placebo group). Hr 0.82 (95% CI 0.57-1.16), p=0.25) The statistical analysis did not adjust for multiplicity, and the hazard ratio should not be used to infer definitive treatment efficacy. In ...
- Source: drugdu
- 71
- September 5, 2024
semaglutide is gaining ground

As we enter 2024, the global competition for “King of Medicine” is becoming increasingly fierce. In the first half of the year, Merck’s PD-1 monoclonal antibody pembrolizumab (trade name: Keytruda, “Keytruda”) successfully won the title of the world’s “king of medicine” with $14 billion. Novo Nordisk’s semaglutide (including 3 brands: Ozempic/Rybelsus/Wegovy) ranked second with sales of about $13 billion in the first half of this year, further narrowing the gap with Keytruda, and the year-on-year growth rate exceeded 40%, leaving suspense for the “king of medicine” competition in the second half of the year. On the other hand, in terms of sales growth, Eli Lilly’s tirpotide (including two brands: Mounjaro/Zepbound) grew 330% year-on-year in the first half of this year to $6.658 billion, making it the fastest-growing drug in history. Since its first indication was approved in 2022, it has grown into a super blockbuster with annual sales of over ...
- Source: drugdu
- 64
- September 5, 2024
Focusing on complement, standardized diagnosis and treatment of rare diseases usher in a new chapter

So far, the 2024 medical insurance catalog adjustment has announced the drugs and related information that have passed the formal review. From the draft for comments, rare disease drugs are still one of the focuses of the medical insurance catalog adjustment. Rare diseases are also called “orphan diseases”. Most of them are congenital diseases, chronic diseases, and may be life-threatening. Although the incidence of rare diseases is low, there are many types of diseases and the number of patients cannot be underestimated. At present, there are more than 7,000 confirmed rare diseases in the world, and there are about 20 million rare disease patients in China1. For a long time, the clinical phenotypes of rare diseases and common diseases overlap greatly, and early diagnosis is difficult, so the misdiagnosis and missed diagnosis rates are high. According to statistics from the National Organization for Rare Diseases in the United States, among ...
- Source: drugdu
- 53
- September 5, 2024
Why are small hearing aids stuck in the neck?

Although hearing aids do not look complicated, their research and development is not simple at all. Digital hearing aids use nonlinear amplification to compress and limit loud sounds and amplify small sounds, making the processed sounds comfortable and clear. To achieve this process, digital hearing aids use DSP digital signal processing chips, use digital technology to segment sound signals, and integrate adaptive noise reduction, acoustic feedback suppression, equalizers and other algorithms that can improve the performance of hearing aids, making the sound of hearing aids clearer and more capable of suppressing whistling. Therefore, in the transformation process of digital hearing aids, the core technology threshold is indeed mainly concentrated in two key areas: First, digital hearing aid chips. These chips are the heart of hearing aids, responsible for processing sound signal amplification, filtering, digital processing, etc. They need to have the characteristics of high speed, low power consumption and high ...
- Source: drugdu
- 66
- September 5, 2024
The Low Point of Performance Due to Centralized Procurement Has Passed, and Tonghua Dongbao Ushered in a Stable Development Period

On the evening of August 30, Tonghua Dongbao (600867.SH) released its 2024 semi-annual report, during the report period, the company achieved operating income of about 740 million yuan, a year-on-year decrease of 45.84%; net profit attributable to shareholders of listed companies of about -230 million yuan; net profit attributable to shareholders of listed companies after deducting non-recurring gains and losses of about -0.13 billion yuan. Industry analysts believe that the reason why Tonghua Dongbao fell into a loss, stemming from the biggest cyclical factors – insulin special centralized procurement. Similar to the first centralized procurement, the results of this year’s renewal have not been reflected in the performance for the time being. The main reason for the company’s first-half performance fluctuations is a one-time dealer to make up the difference, which was also the case in the last centralized procurement, fell to a low point in the second quarter, the ...
- Source: drugdu
- 78
- September 5, 2024
Lancet reports that semaglutide has the potential to be used in heart failure patients

According to analysis, semaglutide reduced the composite risk of cardiovascular (CV) death or worsening heart failure (HF) events by 31%, with incidence rates of 5.4% in the semaglutide group and 7.5% in the placebo group (HR 0.69; 95% CI 0.53-0.89; P=0.0045). semaglutide also reduced the risk of HF worsening by 41% (2.8% vs. placebo 4.7%; HR 0.59 (95% CI 0.41-0.82), p=0.0019). Simeglutide had no significant effect on the incidence of CV mortality (3.1% in the Simeglutide group and 3.7% in the placebo group). Hr 0.82 (95% CI 0.57-1.16), p=0.25) The statistical analysis did not adjust for multiplicity, and the hazard ratio should not be used to infer definitive treatment efficacy. In the United States, semaglutide is not approved for use in heart failure. This study is a summary and post hoc participant level analysis of 3743 patients with a history of HFpEF from four randomized trials, aimed at examining the ...
- Source: drugdu
- 97
- September 4, 2024
AI imaging company Yinghe Yimai announces completion of angel round financing

Today (September 2nd), Shanghai Yinghe Yimai Intelligent Technology Co., Ltd. (hereinafter referred to as “Yinghe Yimai”) announced the completion of an angel round financing of tens of millions of yuan, led by CICC Capital, marking a solid step forward for Yinghe Yimai in promoting the intelligentization of medical imaging. Multiple core products, focusing on intelligent medical imaging Yinghe Medical Pulse was founded in 2020 and is a continuous innovator in the field of medical imaging artificial intelligence based on its newly developed MIIA base model. In response to the current situation where medical imaging AI products are generally single disease, fragmented, and homogeneous, and cannot meet the actual needs of image reading work, Yinghe Medical Pulse is an emerging technology enterprise focused on medical imaging AI integration and research and development. It is committed to providing medical imaging auxiliary tools based on AI and statistical methods, as well as medical ...
- Source: drugdu
- 80
- September 4, 2024
How to select T cell targeted antibodies in the strategy of antibody conjugated LNP (Ab LNP) for mRNA CAR-T therapy

Biological Products Circle September 3, 2024 09:20 Hubei The following article is from the Engineering Bacteria Planet, written by the author Yaojun, who has doubled in numberCurrently, the FDA has approved multiple chimeric antigen receptor (CAR) – T-cell therapies for cancer immunotherapy. However, the production technology based on viral vectors and in vitro cell culture has led to high production costs and potential long-term side effects. With the development of mRNA and lipid nanoparticle (LNP) technology, the idea of in vivo delivery of CARs based on LNP, a non viral vector, is expected to be realized. The primary challenge faced by mRNA LNP mediated CAR-T therapy due to its liver tropism is how to achieve mRNA T cell targeting The use of antibody modified LNP (also known as antibody conjugated LNP, Ab LNP) is an effective solution. So, what are the markers on the surface of T cells and how ...
- Source: drugdu
- 88
- September 4, 2024

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