PharmaFocus Today – Page 374 – media

New injectable cell therapy could resolve osteoarthritis

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have created a promising injectable cell therapy to treat osteoarthritis that both reduces inflammation and also regenerates articular cartilage. Recently identified by the Food and Drug Administration as a public health crisis, osteoarthritis affects more than 520 million people worldwide who deal with pain and inflammation. Osteoarthritis is typically induced by mechanical or traumatic stress in the joint, leading to damaged cartilage that cannot be repaired naturally. “Without better understanding of what drives the initiation and progression of osteoarthritis, effective treatment has been limited,” said lead author Johanna Bolander of WFIRM. “Initially, we studied what goes wrong in osteoarthritic joints, compared these processes to functional environments, and used this information to develop an immunotherapy cell treatment.” Osteoarthritis is a disease of the joint system. The joint includes a synovial membrane—a connective tissue that lines the inner surface of the joint. The membrane functions to protect the joint ...
- Source: drugdu
- 120
- April 25, 2023
In heavyweight obesity fight, Eli Lilly launches Mounjaro head-to-head trial against Novo Nordisk’s Wegovy

The stakes are getting even higher for the fight between Eli Lilly and Novo Nordisk for supremacy in the multibillion-dollar obesity market. Lilly on Friday quietly registered a new phase 3b trial on clinicaltrials.gov. The study, coded SURMOUNT-5, will pit Lilly’s Mounjaro against Novo’s Wegovy in patients with obesity or overweight with weight-related health conditions. The trial aims to enroll 700 participants from 61 sites in the U.S., Canada, South America and several European countries, according to the post. The study is currently expected to officially start next Friday and last for about 78 weeks, with an estimated primary completion date in February 2025. On the study’s primary endpoint, investigators will compare the percentage weight changes between the two drugs by week 72 from baseline. However, it’s not immediately clear whether Lilly is designing SURMOUNT-5 as a superiority study to show Mounjaro is better than Wegovy or just to show ...
- Source: drugdu
- 133
- April 25, 2023
Study finds lack of high certainty evidence on the efficacy and safety of analgesics for low back pain

Despite nearly 60 years of research, there is still a lack of high certainty evidence on the effectiveness and safety of commonly used painkillers (analgesics) for short bouts of low back pain, finds an analysis of the evidence published by The BMJ. The researchers say that until higher quality trials comparing analgesics with each other are published, “clinicians and patients are advised to take a cautious approach to manage acute non-specific low back pain with analgesic medicines.” Analgesics such as paracetamol, ibuprofen, and codeine are widely used to treat acute non-specific low back pain, defined as pain lasting less than six weeks. But evidence for their comparative effectiveness is limited. To fill this knowledge gap, researchers trawled scientific databases for randomized controlled trials comparing analgesic medicines with another analgesic, placebo, or no treatment in patients reporting acute non-specific low back pain. From an ...
- Source: drugdu
- 127
- April 24, 2023
Withdrawal of financial incentives for NHS GPs in Scotland linked to reductions in quality of care

Ending performance-related payments for NHS GPs in Scotland was associated with a decline in the quality of some aspects of care compared with England where financial incentives have continued, finds a study published by The BMJ today. The researchers say further research is needed to better understand the full impact of withdrawal and the accompanying refocusing of quality improvement resources. The NHS Quality and Outcomes Framework (QOF) pay-for-performance scheme began in 2004. It was designed to remunerate general practices for providing good quality care across a range of key areas such as cancer, diabetes, heart disease, mental health, and obesity. In 2016, Scotland abolished the QOF to reduce the bureaucratic burden on GPs and to free-up their time for patients, but continued collecting performance data for some QOF indicators for the next three years. Researchers were therefore able to use this data to evaluate the impact of ...
- Source: drugdu
- 131
- April 24, 2023
High fitness levels may reduce the risk of cardiovascular death

High fitness levels may reduce the risk of death from cardiovascular disease in men with high blood pressure, according to a 29-year study published today in the European Journal of Preventive Cardiology, a journal of the ESC. Nearly 1.3 billion adults aged 30 to 79 years worldwide have high blood pressure (hypertension). Hypertension is a major risk factor for heart attack and stroke and a leading cause of premature death globally. Previous studies have shown that high cardiorespiratory fitness is linked with greater longevity. This study examined the interplay between blood pressure, fitness and risk of death from cardiovascular disease. The study included 2,280 men aged 42 to 61 years living in eastern Finland and enrolled in the Kuopio Ischaemic Heart Disease Risk Factor Study. Baseline measurements were conducted between 1984 and 1989. These included blood pressure and cardiorespiratory fitness, which was assessed as maximal oxygen uptake while riding ...
- Source: drugdu
- 133
- April 24, 2023
Personalized recipe of hopamine can empower patients with Parkinson’s disease

When Marina Noordegraaf was diagnosed with Parkinson’s disease at age 49, she noticed when it came to treatment decisions, she sometimes felt powerless. She observed that she herself played an active role in communicating her hopes and wishes to her healthcare professionals, which were not automatically taken into account. She took back control by taking her own hope seriously, prescribing her own recipe of “hopamine,” a self-invented word representing the uniquely personal set of hopes, desires, experiences, and skills of each individual with Parkinson’s disease, which is caused by a dopamine deficit. Marina Noordegraaf, MSc, together with a team of healthcare professionals at Radboud University Medical Centre in Nijmegen, the Netherlands, led by Professor Bastiaan R. Bloem, MD, PhD, recognized the importance of conveying the message of hopamine to the broader Parkinson’s world. In a commentary published in the Journal of Parkinson’s Disease, the authors propose that ...
- Source: drugdu
- 120
- April 24, 2023
New research reveals how coffee and tea can affect risk of early death for adults with diabetes

If you have type 2 diabetes, drinking more coffee, tea or plain water may lower your risk of dying prematurely from any cause by about 25%, a new study found. However, drinking more sugar-sweetened beverages raised the risk of heart disease by 25% and the risk of dying from a heart attack or another cardiovascular event by 29%, the study said. Research has shown cardiovascular disease is the most common cause of death for people with type 2 diabetes. “Certain beverages are absolutely more beneficial than others, depending on which type of beverage you’re comparing,” said study author Qi Sun, an associate professor of nutrition and epidemiology at the Harvard T.H. Chan School of Public Health in Boston. “Based on our study I would rank black coffee, unsweetened tea and plain water higher than low-fat milk, fruit juice or artificially sweetened beverages,” he said. “Sugar-sweetened beverages like ...
- Source: drugdu
- 129
- April 24, 2023
Short exposure to bright light before night shift may help reduce fatigue and errors

Nurses exposed to 40 minutes of bright light before their night shifts feel less fatigued and make fewer errors at work, according to a study led by McGill University. The nurses also slept better after their shifts. “Healthcare workers are experiencing high levels of fatigue due to staffing shortages, difficult schedules, and heavy workloads. Further, the cost of medical errors has been estimated at tens of billions of dollars per year in North America,” says Jay Olson, the senior author of the recent study in Sleep Health, who completed his PhD at McGill University and is now a Postdoctoral Fellow at the University of Toronto. “Our study shows that feasible changes, such as getting light exposure before the night shift, may help reduce fatigue and its effects on performance at work, something which could benefit both the nurses and their patients.” Light exposure leads to a significant reduction ...
- Source: drugdu
- 119
- April 24, 2023
Millions of cancer patients benefit from Elekta’s Flexitron

by John Pinching Brachytherapy is a precise type of radiotherapy that can be used to treat several cancers Elekta has announced that around two million brachytherapy treatments have been delivered by healthcare providers using the company’s Flexitron therapy. Brachytherapy is a very precise type of radiotherapy that can be used to treat a wide variety of cancers. Also known as interventional radiotherapy, it sends a high level of radiation directly onto the tumour, while also minimising exposure to healthy tissue. The treatment has been administered at a high dose rate (HDR) at several locations. One of the most notable sites – Amsterdam University Medical Centers (Amsterdam UMC) – recently contributed to the significant milestone by acquiring the 1,000th Flexitron treatment to be manufactured at Elekta’s production facility in Veenendaal. Indeed, Amsterdam UMC has been providing brachytherapy treatments for more than four decades, using earlier generation brachy afterloaders and Flexitron. The ...
- Source: drugdu
- 138
- April 24, 2023
US Supreme Court delays abortion pill access decision

By Nadine Yousif & Robin Levinson-King BBC News The US Supreme Court has extended until Friday a temporary block on limits to access of a popular abortion pill. A Texas judge suspended approval of abortion drug mifepristone on 7 April, questioning its safety. Parts of that decision were upheld on appeal, prompting the Biden administration to make an emergency request to the Supreme Court. It’s the most significant such case since the Supreme Court last year ended the nationwide right to abortion. The pill – used in more than half of abortions in the US – was first approved by the Food and Drug Administration (FDA) more than two decades ago. Here’s how we got here. What has happened so far? Earlier this month, a federal judge in Texas issued a preliminary injunction revoking the FDA’s approval for the drug while he hears a lawsuit brought by a group of ...
- Source: drugdu
- 138
- April 24, 2023

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