The upgraded McDonald criteria for multiple sclerosis (MS) has presented increased diagnoses in patients with clinically isolated syndrome (CIS), however a recent study of the criteria suggests that they may misguide to a number of false positive MS diagnoses in patients with a milder disease condition.
Multiple sclerosis is a neurological disease affecting the myelin sheath that surrounds nerve fibers in the central nervous system, composed of the brain, spinal cord, and optic nerve. Since myelin is destroyed, it creates lesions which leads to an interruption in communication between the brain cells.
Gene expression in specific cells and in specific regions can provide a more precise, neuroprotective approach than traditional treatments for neurological diseases. For multiple sclerosis, specifically, increasing cholesterol synthesis gene expression in astrocytes of the spinal cord can be a pathway to repair nerves that affect walking.
Monitoring disease activity in individuals with multiple sclerosis, either to predict flare-ups or to check treatment response, might be done with a simple blood test that measures levels of a nerve protein, according to a new study from Norway.
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