Research finds use of progestogen is associated with a 20-30% higher risk but this falls after no longer taking it All types of hormonal contraceptives carry a small increased risk of breast cancer, according to research establishing a link with progestogen pills for the first time. The use of progestogen is associated with a 20-30% higher risk of breast cancer, data analysis by University of Oxford researchers has established. This builds on previous work showing that use of the combined contraceptive pill, which contains oestrogen and progestogen, is associated with a small increase in the risk of developing breast cancer that declines after stopping taking it. Claire Knight of Cancer Research UK, which funded the study, said the risk was small and should not discourage most people from taking the pill. She said: “Women who are most likely to be using contraception are under the age of 50, where the risk of ...
The Jak2/Stat5 genetic pathway which controls the natural development of mammary glands and also breast cancer cells is regulated by the enzyme cyclophilin A (CypA), find VCU Massey Cancer Center researchers headed by Charles Clevenger, M.D., Ph.D., which could be a new target for breast cancer therapies. “This research identifies cyclophilin A as a relevant target for therapeutic intervention in breast cancer. Because FDA-approved drugs are available to inhibit the action of CypA, translation of these findings to breast cancer patients should be rapid,” said Clevenger, interim associate director for basic research, member of the Cancer Cell Signaling research program and Carolyn Wingate Endowed Chair in Cancer Research at VCU Massey Cancer Center. “No study to date had previously examined the loss of CypA function during mammary development and the formation of cancer.” Clevenger and his associates could suppress the initiation of the Stat5 pathway in mouse models having ER-positive ...
Finding the ultimate treatment for breast cancer is still a dream for all the pharma companies worldwide. At present, only hormonal therapy, Pfizer’s Ibrance, Eli Lilly’s Verzenio and Novartis’s Kisqali are available for breast cancer treatment.
Endomag received premarket approval from the FDA for Magtrace, the novel non-radioactive dual-tracer for lymphatic plotting in breast cancer patients which facilitates the implementation of magnetic detection during sentinel lymph node biopsy procedures to spot sentinel lymph nodes for surgical excision.
More than 2.5 million people work night-shifts. In 2007, the International Agency for Research on Cancer (IARC) reported that working shifts generally disturbs momentum classified as being “probably carcinogenic to humans”.
A shocking report revealed that an error in breast cancer screening tests may have affected a vast number of women across England. Due to a computer algorithm failure dating back to 2009, a group of women was not sent for routine breast cancer screening tests before their 71st birthdays. Public Health England (PHE) predicted that around 450,000 women may have been affected due to these screening errors during 2009.
Breast Cancer appears when unusual cells start growing in breast tissue and can affect both women and men. It was estimated that in the U.S. alone there will be a total of 330,080 new cases of breast cancer in women and about 2,550 in men by the end of 2018.
At present, breast cancer patients need to wait for nearly two to three months to find out via a scan whether palbociclib is working. This new test could detect the circulating tumor DNA which enters the bloodstream. By measuring and comparing PIK3CA levels in a blood test before and 15 post palbociclib therapy, one could predict the effectiveness of the drug.
The amazing discovery under the authorship of Professor Chenfang Dong from the Zhejiang University School of Medicine in Hangzhou, China revealed that the widely used osteoporosis drug named zoledronic acid, inhibits UGT8 activity directly, which led to the prevention of basal-like breast cancer.
AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., US (Merck: known as MSD outside the US and Canada) today presented data from the Phase III OlympiAD trial, showing the final overall survival (OS) results for LYNPARZA®(olaparib) in metastatic breast cancer at the American Association for Cancer Research (AACR) Annual Meeting in Chicago, April 14-18, 2018.
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