Search Results for “EC” – Page 438 – media

Making young mice old in a matter of three weeks

In a paper recently published in PNAS Nexus, researchers from the Department of Comparative Biosciences at the University of Illinois Urbana-Champaign describe how they were able to inhibit the activity of a specific neuronal cell type in the hippocampus to induce cellular and behavioral changes associated with aging. Their study confirms a causal relationship between reduced function of certain interneurons in the brain and cognitive decline. In addition, their novel experimental model may be useful for studying age-related cognitive disorders. First author Jinrui Lyu, a graduate student in the Neuroscience Program and the Department of Comparative Biosciences, performed and analyzed the experiments for the study. Corresponding author Uwe Rudolph is professor and head of the Department of Comparative Biosciences in the College of Veterinary Medicine. These authors answered some questions about the design and significance of their study. What was the motivation for your study? Our lab is interested in why ...
- Source: drugdu
- 117
- April 29, 2023
Older drivers drinking or using drugs up to four times likelier to be at fault during a car crash

Substance use among older drivers increases the probability of them being at-fault two to four times during a crash, a new study, analyzing nine years’ worth of US nationwide highway traffic data, shows. Although older drivers are less likely to report using substances, this research found that out of a sample of 87,060 drivers involved in two moving vehicle crashes, more than one-third were motorists over the age of 70 who tested positive for substances. Findings are published today in the journal Traffic Injury Prevention. “In general older drivers are at an elevated risk for being at-fault in a fatal car crash, this is especially the case when they are under the influence of alcohol or drugs,” explains the lead author, Dr. Satish Kedia, a Professor at the University of Memphis School of Public Health’s Division of Social and Behavioral Sciences. In 2020, there were almost 48 million licensed drivers ages 65 ...
- Source: drugdu
- 127
- April 29, 2023
US cigarette smoking rate falls to historic low, but e-cigarette use keeps climbing

The percentage of adults who smoked cigarettes in the United States fell to a historic low last year, the US Centers for Disease Control and Prevention found. However, e-cigarettes are becoming even more popular. About 11% of adults told the CDC last year that they were current cigarette smokers, according to the latest preliminary data from the National Health Interview Survey, a biannual survey that provides general information about health-related topics. The survey includes responses from 27,000 people age 18 and older. In 2020 and 2021, about 12.5% of adults said they smoked cigarettes. This is a significant drop from when surveys like these started. Surveys of Americans in the 1940s found that about half of all adults said they smoked cigarettes. Rates began to decline in the 1960s, and more recently, in 2016, 15.5% of adults said they smoked cigarettes. Recent studies have shown some groups ...
- Source: drugdu
- 119
- April 29, 2023
Amphera and Alligator Bioscience reveal mitazalimab-MesoPher update

Therapy is being used during pivotal phase 1 study into patients with pancreatic cancer Alligator Bioscience and Amphera have announced that the last patient in their REACTIVE-2 phase 1 research has been dosed. The research is evaluating mitazalimab when used in combination with MesoPher among patients with metastatic pancreatic cancer. The single location, open-label trial is assessing the efficacy and safety of Alligator’s lead candidate mitazalimab along with Amphera’s cancer vaccine MesoPher. It involves patients who have already undergone standard of care treatment with mFOLFIRINOX. The REACTIVE-2 study is currently being performed at Erasmus Medical Center in Rotterdam, the Netherlands, while initial results are expected later this year. Søren Bregenholt, chief executive officer at Alligator Bioscience, reflected: “Our CD40 agonist and Amphera’s cancer vaccine have both shown great promise in their own separate clinical studies emphasising the crucial role of dendritic cells and other myeloid cells in immune response to ...
- Source: drugdu
- 125
- April 29, 2023
Immunotherapy strongly improves prognosis of babies with leukemia

Immunotherapy with blinatumomab leads to a strongly improved survival rate—from 66% to 93%—for children with an aggressive form of acute lymphoblastic leukemia (ALL). They also had fewer side effects from the treatment. Based on the results, blinatumomab will now become standard treatment worldwide for babies with this aggressive form of leukemia. Three quarters of babies with acute lymphoblastic leukemia (ALL)—three babies a year in the Netherlands—have a particular fault in the DNA of their leukemia cells. This so-called KMT2A rearrangement leads to an aggressive form of ALL with a poor prognosis. Despite intensifying chemotherapy, the prognosis for these babies has not improved in recent decades. Intensive chemotherapy works very well for half of the babies. But in the other half of the children, the disease returned within two years, or children died from the disease or sometimes from the side effects of the therapy. 90% of recurrences—when the cancer comes ...
- Source: drugdu
- 134
- April 28, 2023
Sanofi, Regeneron unveil ‘blow-out’ smoker’s lung drug data

March 23 (Reuters) – Sanofi’s (SASY.PA) asthma drug Dupixent met all targets in a trial to treat “smoker’s lung”, potentially adding billions to the French drugmaker’s growth prospects, but also underscoring a heavy reliance on its bestseller. In a late stage trial Dupixent, jointly developed with Regeneron (REGN.O), led to a 30% reduction in moderate or severe acute exacerbations of chronic obstructive pulmonary disease (COPD), a potentially deadly disease marked by progressive lung function decline. Shares in Sanofi and Regeneron surged after they said in a joint statement on Thursday a Phase III trial involving 939 current or former smokers also showed improvements in lung function, quality of life and respiratory symptoms. The French group’s stock was up 5.2% at 1205 GMT, reaching a seven-month high and far outperforming the STOXX Europe 600 Health Care index (.SXDP), which was little changed. Regeneron jumped 8.6% in U.S. ...
- Source: drugdu
- 172
- April 28, 2023
Eli Lilly to sell low blood sugar drug Baqsimi to Amphastar in deal worth over $1bn

The drug is available in 27 markets, with worldwide sales totalling over $139m in 2022. Eli Lilly will sell its low blood sugar drug Baqsimi to Amphastar Pharmaceuticals in a deal worth over $1bn, the two companies announced. Under the terms of the definitive agreement, Amphastar will pay Lilly $500m at closing and an additional $125m after one year, with Lilly also eligible to receive sales-based milestone payments of up to $450m. Baqsimi is the first and only nasally administered glucagon to treat severe hypoglycaemia – very low blood sugar – in diabetes patients aged four years and above. Classed as a diabetic emergency, severe hypoglycaemia is a complication that can occur in diabetes patients who take insulin and certain anti-diabetic tablets. The condition is characterised by altered mental or physical functioning, including confusion and disorientation, convulsions, loss of consciousness and coma. Lilly launched Baqsimi ...
- Source: drugdu
- 162
- April 28, 2023
Leisure-time physical activity may improve mental health in teens

A recent study led by the University of Eastern Finland suggests that regular leisure-time physical activity, even in small doses, is associated with lower odds of depression, anxiety, chronic stress, and school psychologist visits among Finnish adolescents. However, the relationship between active school transport, i.e., walking or cycling to school, and mental health remains inconclusive. The findings were published in the prestigious Scandinavian Journal of Medicine & Science in Sports. Regular physical activity can improve mental health through various pathways, such as increasing the production of “feel-good” hormones, enhancing sleep quality, and boosting self-confidence. While mental health problems are common, few large population-based studies have examined the relationship between physical activity and adolescent mental health. Furthermore, it is currently unknown whether active school transport can have beneficial effects on mental health. The researchers observed that leisure-time moderate-to-vigorous physical activity was associated with better mental health among nearly 33,000 15-to-16-year-old ...
- Source: drugdu
- 148
- April 28, 2023
New research suggests that french fries may be linked to depression

French fries — they’re greasy, starchy and a comfort food for many. But reaching for fried foods may have a negative impact on mental health. A research team in Hangzhou, China, found that frequent consumption of fried foods, especially fried potatoes, was linked with a 12% higher risk of anxiety and 7% higher risk of depression than in people who didn’t eat fried foods. The link was more pronounced among young men and younger consumers. Fried foods are known risk factors for obesity, high blood pressure and other health effects. These results “open an avenue in the significance of reducing fried food consumption for mental health,” according to the paper published Monday in the journal PNAS. However, experts who study nutrition said the results are preliminary, and it’s not necessarily clear whether the fried foods were driving mental health issues, or people experiencing symptoms of ...
- Source: drugdu
- 125
- April 28, 2023
UK monkeypox vaccine rollout to wind down

The UK Health Security Agency (UKHSA) has announced its vaccination programme against mpox will end this summer. Cases of the disease have fallen from a peak of 350 per week in July to just six new cases so far in 2023, three of which were caught overseas. First doses of the vaccine will remain available to those at highest risk until 16 June, with second doses available until the end of July. The UKHSA says it will monitor cases and restart the programme if needed. While the mpox, formerly known as monkeypox, virus can infect anyone, most UK cases were among men who have sex with men. Anyone eligible who has not yet received a vaccine is being encouraged to book an appointment to protect themselves before summer. Greg Owen, from sexual health and Human Immunodeficiency Virus (HIV) charity the Terrence Higgins Trust, said: ...
- Source: drugdu
- 137
- April 28, 2023

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