Some types of epilepsy medicine taken during pregnancy are associated with an increased risk of severe psychiatric disorders in children. This is the conclusion of a comprehensive study of 38,000 children of mothers with epilepsy by researchers from Aarhus University. The research is published in the journal JAMA Neurology. While it has long been known that some forms of epilepsy medicine used during pregnancy are associated with a risk of birth defects, this new study is the most comprehensive study of children’s mental health so far. Among other things, the researchers found a worrying link between the antiseizure medication valproat and the child’s risk of developing a number of different psychiatric disorders. “Our study shows that four out of ten children born to mothers with epilepsy who had used valproat during pregnancy were diagnosed with a psychiatric disorder before the age of 18, and that the drug was particularly associated with an ...
GW Pharmaceuticals’ Epidyolex has received approval from the European Commission (EC) for the treatment of seizures associated with tuberous sclerosis complex (TSC) – its third indication in Europe. Specifically, Epidyolex (cannabidiol) has been approved as an adjunctive treatment of seizures associated with TSC for patients aged two years and older. TSC is a rare genetic condition that causes mostly benign tumours to grow in vital organs including the brain, skin, heart, eyes, kidney and lungs. The condition is typically diagnosed in childhood and the most common neurological feature in TSC is epilepsy. It is also associated with an increased risk of autism and intellectual disability, although the severity of the condition can vary widely. The EC approval is based on data from a Phase III trial evaluating Epidyolex for the treatment of seizures associated with TSC. This study hit its primary endpoint of reduction in seizure frequency, with seizure reduction ...
Source:https://www.medicalnewstoday.com/articles/327296.php Using a new type of genetic engineering tool called epigenome editing in mice, scientists have restored irregularities in the developing brain that arise from a gene mutation. New research in mice suggests that gene editing could prevent brain developmental disorders.Epigenome editing is a way of altering the expression, or reading, of genes without altering their underlying DNA code. A team from Johns Hopkins University in Baltimore, MD, led the Nature Communications study that focuses on the protein C11orf46. One of the study’s corresponding authors is Dr. Atsushi Kamiya, who is an associate professor of psychiatry and behavioral sciences at Johns Hopkins University School of Medicine. In humans, mutations in the section of DNA that contains the C11orf46 gene can lead to WAGR syndrome, a genetic condition that can cause intellectual disability and impair many systems of the body. The researchers found that C11orf46 directs the development of the corpus ...
After a serious injury or surgery, there is always a specific amount of time needed to recover. During this period, varied resources are needed to regain the strength of doing things independently. In hospitals, the continuous availability of physiotherapists will help in rehabilitation therapy.
Physician Andrew Wakefield reported in 1998 that the measles vaccine leads to autism. Even though his research was discredited, the damage was done and there came a fall in measles vaccinations due to which the prevalence of measles increased.
Since their discovery in the 18th Century, vaccines have been a boon to medicine in its fight against deadly infectious diseases despite skeptical claims against it. They have controlled several and eradicated a number of infections globally.
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Most autistic children struggle with communication and social skills. Though the causes are not completely understood there are indications of associations like women taking folate supplements during pre-conception and during gestation showed a lesser chance of having an offspring with autism spectrum disorder (ASD).
A recent ruling declared that Italian families are not obligated to get their children vaccinated against measles and other infectious diseases.
EIP Pharma raised $20.5 million series B funding to support Neflamapimod, the phase 2b program of its Alzheimer treatment. The funding is also to build the team and to support other research studies related to central nervous system disorders.
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