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Lawmakers look to crack down on Big Pharma tax breaks

Drug pricing crackdowns aren’t the only way lawmakers are looking to reign in pharma’s business practices. With scrutiny of the industry intensifying on Capitol Hill, a Senate committee is now shining a spotlight on how Big Pharma is paying taxes, too. Earlier this month, Senate Finance Committee Chair Ron Wyden, D-Ore., released a memo revealing the latest findings of an ongoing investigation into how the industry has used a Trump-era law to reap massive decreases in tax rates. “Big Pharma gets us coming and going — they charge Americans sky-high prices and they pay absolute rock-bottom taxes,” Wyden said in a statement. According to Wyden, the industry has been leveraging a 2017 law that triggered a 40% reduction in the industry’s tax rate since it was enacted. All told, Wyden’s investigation found that in 2019 and 2020, the industry paid an effective tax rate of 11.6%, down from 19.6% on ...
- Source: drugdu
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- June 3, 2023
New links found between personality and cognitive abilities

In a new landmark study, University of Minnesota research shows surprising links between human cognition and personality—pillars of human individuality that shape who we are and how we interact with the world. Personality influences our actions, emotions and thoughts, defining whether we are extroverted, polite, persistent, curious or anxious. On the other hand, cognitive ability is the umbrella that reflects our capability for navigating complexity, such as articulating language, grasping intricate mathematics and drawing logical conclusions. Despite the prevailing belief that certain connections exist—for instance, introverted individuals are often perceived as more intelligent—scientists lacked a comprehensive understanding of these intricate connections. The research, published in the Proceedings of the National Academy of Sciences, synthesizes data from over 1,300 studies from the past century, representing more than 2 million participants from 50 countries and integrating data from academic journals, test manuals, military databases, previously unpublished datasets and even proprietary databases of ...
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- June 3, 2023
Study shines light on cause of chronic kidney disease

Fresh insights into a protein that causes damage in kidneys and hearts could open up new treatment options for chronic kidney disease, research shows. In a study in mice, scientists found that scarring in kidneys and hearts was driven by a protein called Indian Hedgehog (IHH), which is produced and released by a subset of cells in aged and injured kidneys. Experts say further studies are needed to explore IHH as a potential target for therapies to treat chronic kidney disease (CKD)—a condition that affects 10 percent of the world’s population. CKD is a term used to cover any form of kidney disease that continues for more than a few months. It can affect people of any age, but older people are more likely to experience some level of CKD. While CKD primarily causes damage to kidneys, it is also a major risk factor for accelerated cardiovascular disease and premature ...
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- 125
- June 3, 2023
Argentina allows morning-after pill to be bought over counter

IMAGE SOURCE,REUTERS Image caption, An Argentine feminist at a protest (file image) By Oliver Slow BBC News Women in Argentina will no longer require a prescription to get emergency contraception. The government said making the morning-after pill more easily available removed an “important barrier” for those seeking terminations. The move was welcomed by feminist groups, who see it as a sign of progress in the Catholic-majority country. However critics said the move displayed a “failure of pregnancy prevention”. The health ministry said the measure would help avoid unintentional pregnancies by overcoming “difficulties of access to health services, contraception supplies, and education” faced by some. “This removes an important barrier to access,” Valeria Isla, director of sexual and reproductive health at the ministry, told Reuters news agency. “People can have this method of contraception as support before an emergency happens.” Vanessa Gagliardi, leader of the feminist group Juntas y a ...
- Source: drugdu
- 220
- June 3, 2023
EULAR announces the launch of new survey targeted directly at RMD patients

The European Alliance of Associations for Rheumatology (EULAR) has announced the launch of the EULAR Impact of RMDs Survey, an online questionnaire targeted directly at RMD patients. The data collected through this survey will be an important resource for researchers, healthcare professionals, and patients alike, providing a comprehensive database of patient-reported outcomes on their healthcare situation, and how the illness affects their social and occupational lives. By collecting and analysing data from a large number of patients with RMDs on a recurring basis, the survey will provide valuable insights into the burden of disease and help improve the overall care for people living with these conditions. “EULAR is committed to improving the lives of people with rheumatic diseases,” said Dr Anna Molto, chair of the EULAR Research sub-committee of epidemiology and public health and lead of the project. “The launch of this survey is a significant step forward in our ...
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- June 3, 2023
Medicare holds firm on Alzheimer’s drug coverage policy

By Rachel Cohrs CMS Administrator Chiquita Brooks-LasureCHIP SOMODEVILLA/GETTY IMAGES WASHINGTON — Despite pressure from Congress and advocates, Medicare isn’t changing its coverage plan for new Alzheimer’s drugs anytime soon. Medicare on Thursday issued a statement reiterating its intent to require patient registries to collect data about how medications perform even after they gain full Food and Drug Administration approval. Eisai’s Leqembi could gain full approval within the next month, so time is running short for the agency to solidify details. Right now, Leqembi and Biogen’s Aduhelm only have accelerated approval from the FDA, and are subject to even more restrictive coverage limits that require patients to be enrolled in a clinical trial to receive the medications. If Leqembi wins full approval, those restrictions will relax slightly, but providers would still need to collect data about all patients who receive the drugs in a patient registry. Medicare had previously announced ...
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- June 3, 2023
Recurrent cases of ocular toxoplasmosis more likely to occur in women

Women are more likely to experience recurrent cases of the Toxoplasma parasite, according to new Flinders University research. With the condition putting people at risk of further attacks of toxoplasmosis that can progressively damage the retina and lead to vision loss, international experts have demonstrated that women are also more likely to have more than one lesion in their eyes. The new study, which analyzed the impact of toxoplasmosis on 262 participants at an eye clinic in Brazil, aims to address differences in the way dangerous infections like toxoplasmosis impact people because of their gender to develop targeted treatments. Closely associated with cats, Toxoplasma is a parasite that causes the infectious disease known as toxoplasmosis. For humans, while domestic cat feces can be a carrier, the most common route of infection is by eating undercooked or raw meat sourced from infected livestock. Professor Justine Smith (Study Senior Author, Strategic Professor ...
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- June 3, 2023
MedTech Europe sets out position on cybersecurity, making case for reliance on MDR

Dive Brief MedTech Europe has set out its vision for cybersecurity in the medical technology ecosystem in a paper that argues for industry-specific legislation. The trade group outlines three areas of discussion, starting with its belief that medtech security should be regulated under sectoral legislation such as the Medical Devices Regulation (MDR) and In Vitro Diagnostic Medical Devices Regulation (IVDR). Other parts of the paper address MedTech Europe’s preferred approach for tackling ransomware and support for actions to improve digital literacy in general and cybersecurity skills in particular. Dive Insight More connected medical devices have increased the risk that hackers will access confidential data or gain the ability to modify technologies in ways that put patients at risk. As the risks increase, medical device manufacturers “continue to invest significant resources in guaranteeing state of the art cybersecurity for all their products and services,” the trade group wrote. Other groups including ...
- Source: drugdu
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- June 2, 2023
Personalized video exercises may be useful to support rehabilitation for people with RMD

Apps have become ubiquitous in many parts of life, including for health. For people with an RMD, personalized video exercises (PEV) may be useful to support rehabilitation and physical exercise. In an abstract shared at the 2023 EULAR annual congress, Davergne and colleagues explore the effectiveness of PEV provided through Apps in supporting rehabilitation for people with disability. The impact was measured in terms of a range of outcomes, including the effect on functional capacity, confidence in exercise performance, use of care, health-related quality of life, adherence, and adverse events. Data were collected in a systematic review of randomized controlled trials which evaluated the effect of Apps providing PEV to support physical rehabilitation for any RMD. The primary outcome was functional capacity at the end of the intervention. In total, 7 articles were included, representing data from 906 participants, 93% of whom were adults. The Apps used in these studies ...
- Source: drugdu
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- June 2, 2023
FDA warns patients about compounded versions of Novo Nordisk’s Ozempic, Wegovy

In the rush to supply prescriptions of Novo Nordisk’s popular diabetes and weight loss meds, some pharmacies are making unauthorized versions of Ozempic and Wegovy, the FDA warned on Tuesday. Some compounding pharmacies, which are permitted to make drugs during times of shortage, are using unauthorized versions of semaglutide—the key active ingredient in the GLP-1 drugs. Compounding pharmacies are currently allowed to make Ozempic and Wegovy because they are in short supply. But they must use approved ingredients, the FDA points out. The agency has received adverse event reports after patients have used compounded semaglutide. In some cases, compounders may be using salt forms of semaglutide, called semaglutide sodium or semaglutide acetate, which have not been proven to be safe or effective. The FDA asks users of Ozempic and Wegovy to get a prescription from a licensed provider and only obtain drugs from state-licensed pharmacies or outsourcing facilities registered with ...
- Source: drugdu
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- June 2, 2023

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