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Understanding how hormones influence anemia

Northwestern Medicine scientists have uncovered how peptides produced by bones during inflammation prevent anemia in mice, according to a recent study published in the journal Blood. Inflammation, a feature of many chronic illnesses, is known to lead to the concomitant increased production and cleavage of fibroblast growth factor 23 (FGF23), a hormone previously linked to iron dysregulation. Particularly in patients with chronic kidney disease, the increase of FGF23 is associated with a reduction in iron levels, leading to anemia and increased morbidity, said Valentin David, Ph.D., the Frank Krumlovsky, MD, Professor of Medicine in the Division of Nephrology and Hypertension and senior author of the study. “Intact FGF23 is a phosphaturic hormone mainly secreted by bone cells,” David said. “It was first discovered in 2000, and we have been following it closely since then. We have studied heavily the role of FGF23 in regulating classical mineral metabolism factors, including phosphate and vitamin D. ...
- Source: Journal information: Blood
- 162
- May 28, 2023
Causal association found between evening social media use and delayed sleep

A team of psychiatrists from Duke University and Yale University has found what they describe as a causal association between evening social media use and delayed sleep. In their study, reported in the journal Sleep Medicine, the group tracked social media use and delayed sleeping patterns for 44,000 Reddit users. Prior research has shown that exposure to blue light, such as that emitted from phones and tablet computers, can lead to sleep problems because it interferes with production of melatonin. In this new effort, the researchers have found that posting to a social media site prior to normal bedtime may delay the time that people go to sleep. The team wondered whether social media posting might be interfering with people’s normal sleep patterns, especially in the evening hours. To find out, they conducted an exhaustive analysis of data on the social media site Reddit. As with other social media sites, users on Reddit can post comments ...
- Source: Journal information: Sleep Medicin
- 114
- May 28, 2023
A new antibiotic, discovered with artificial intelligence, may defeat a dangerous superbug

Using artificial intelligence, researchers say, they’ve found a new type of antibiotic that works against a particularly menacing drug-resistant bacteria. When they tested the antibiotic on the skin of mice that were experimentally infected with the superbug, it controlled the growth of the bacteria, suggesting that the method could be used to create antibiotics tailored to fight other drug-resistant pathogens. What’s more, the compound identified by AI worked in a way that stymied only the problem pathogen. It didn’t seem to kill the many other species of beneficial bacteria that live in the gut or on the skin, making it a rare narrowly targeted agent. If more antibiotics worked this precisely, the researchers said, it could prevent bacteria from becoming resistant in the first place. The study was published in the journal Nature Chemical Biology. “It’s incredibly promising,” said Dr. Cesar de la Fuente, an assistant professor at the University of Pennsylvania’s ...
- Source: CNN
- 135
- May 28, 2023
Mirroring Senate counterparts, House committee advances PBM reforms

The House Energy & Commerce Committee advanced multiple bills to the House floor in a seven-hour hearing Wednesday, some of which included measures to address drug pricing transparency and PBMs. The highlights included two bills, among other healthcare measures, that would advance accountability around PBMs and on drug pricing, including the embattled 340B program. One bill, also known as the “Promoting Access to Treatments and Increasing Extremely Needed Transparency,” or PATIENT Act, would ban spread pricing where PBMs can charge that state more than they reimburse pharmacies. That same ban was included in a Senate bill that also recently advanced out of committee. The House bill, introduced by bipartisan sponsors Cathy McMorris Rodgers (R-WA), committee chair, and Frank Pallone (D-NJ), passed unanimously at 49-0. Both the House and Senate bills would also add new transparency measures around PBMs. Rodgers said during the committee meeting that the bill is “the product ...
- Source: https://endpts.com/
- 120
- May 28, 2023
Acurable prepares to challenge ResMed for sleep apnea diagnosis market

Dive Brief Acurable is preparing to challenge ResMed and Resonea for the sleep apnea diagnosis market in the U.S. Having received 510(k) clearance in February, Acurable plans to start selling its AcuPebble Ox100 device in the U.S. this summer. The device records the sounds of the patient’s respiratory and cardiac functions and monitors blood oxygen levels to assess suspected obstructive sleep apnea. ResMed acquired a rival device, now sold as onesleeptest, through its 2021 Ectosense takeover and Resonea offers some of the same capabilities through its Drowzle Pro mobile application. Dive Insight AcuPebble Ox100 builds on an older Acurable device, AcuPebble SA100, that received 510(k) clearance in the summer of 2021. Like the older device, AcuPebble Ox100 features a sensor that the patient sticks to their neck to record respiratory and heart sounds. The acoustic signals are processed and analyzed by algorithms to detect sleep apnea. The new device combines ...
- Source: https://www.medtechdive.com/news/acurable-launch-sleep-apnea-diagnosis/651232/
- 99
- May 28, 2023
Groundbreaking study targets ‘jumping genes’ in the entire genomes of the human large intestine

The Korea Advanced Institute of Science and Technology (KAIST) and their collaborators have conducted a groundbreaking study targeting ‘jumping genes’ in the entire genomes of the human large intestine. Published in Nature on May 18 2023, the research unveils the surprising activity of ‘Long interspersed nuclear element-1 (L1),’ a type of jumping gene previously thought to be mostly dormant in human genomes. The study shows that L1 genes can become activated and disrupt genomic functions throughout an individual’s lifetime, particularly in the colorectal epithelium. (Paper Title: Widespread somatic L1 retrotransposition in normal colorectal epithelium, https://www.nature.com/articles/s41586-023-06046-z) With approximately 500,000 L1 jumping genes, accounting for 17% of the human genome, they have long been recognized for their contribution to the evolution of the human species by introducing ‘disruptive innovation’ to genome sequences. Until now, it was believed that most L1 elements had lost their ability to jump in normal tissues of modern ...
- Source: https://www.news-medical.net/news/20230525/Groundbreaking-study-targets-jumping-genes-in-the-entire-genomes-of-the-human-large-intestine.aspx
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- May 28, 2023
【EXPERT Q&A】What aspects should be considered when sending samples to clients? How can we create opportunities for sales techniques, generate chances for client visits, and encourage clients to sign contracts promptly?

When sending samples, it is important to select the right customers with potential demand, pay attention to the details of customized samples, ensure the quality, and provide secure packaging. Including a company catalog and sample list can help customers understand your company and products better. Following up after sending the samples and maintaining regular communication with the customer can help improve the order conversion rate.
- Source: drugdu
- 266
- May 28, 2023
customized sample details order conversion rate sample packaging sample quality samples
【EXPERT Q&A】Could someone explain the WC certification documents for exporting Active Pharmaceutical Ingredients (APIs) to the European Union?

Drugdu.com expert’s response: Active pharmaceutical ingredients (APIs) intended for export to the European Union need to obtain the Good Manufacturing Practice (GMP) certification and Written Confirmation (WC) document issued by the European Medicines Agency (EMA). GMP certification for pharmaceuticals involves rigorous auditing of the manufacturer’s quality management system, production processes, equipment, and personnel, ensuring the produced pharmaceuticals meet the quality and safety requirements of the EU. GMP certification is a prerequisite for obtaining the WC document; only businesses that have passed GMP certification can obtain the WC document and export APIs to the EU market. The WC document is one of the required export documents for APIs to the EU, aiming to ensure that APIs exported to the EU meet the EU’s quality and safety requirements. To apply for the WC document, the API manufacturing company needs to submit the following information to the EMA: 1.Name of the API and its ...
- Source: drugdu
- 96
- May 28, 2023
Researchers identify potential new treatment for those who act out their dreams while sleeping

Mount Sinai researchers have published what they say is the first study to identify a new form of treatment for rapid eye movement (REM) sleep behavior disorder. This condition affects more than 3 million Americans, mostly adults over the age of 50, who often unknowingly physically act out their dreams with vocal sounds or sudden, violent arm and leg movements during slumber, leading to significant injury to themselves or bed partners. The new study, published in the Journal of Neuroscience, outlines a novel model to better characterize how REM sleep behavior disorder develops due to neurodegeneration—when brain cells lose function over time—which is associated with the accumulation of tau protein. This model provides an early-life biomarker of impending deterioration of the brain, which could guide future prevention and treatment. The paper also demonstrates for the first time that sleep medications known as dual orexin receptor antagonists—commonly used to treat insomnia, or difficulty falling ...
- Source: Journal of Neuroscience
- 235
- May 27, 2023
Bipartisan lawmakers pressure FDA on common chemotherapies now in shortage

The US House of Representatives has turned a sharp eye to drug shortages over the past few months, with hearings and new caucuses to try and dampen the situation, but another bipartisan letter sent yesterday to FDA aims to keep the pressure up on cancer drug shortages. Reps. Debbie Dingell (D-MI) and Tim Walberg (R-MI) penned the letter to FDA Commissioner Rob Califf, expressing concerns around the shortages of two commonly used chemotherapies used to treat cancer, known as cisplatin and carboplatin, which are used for lung, gynecologic and breast cancers, as well as methotrexate, which is used in treating other forms of cancer. “These chemotherapy drug shortages come amid a shortage of other critical cancer medications. Taken together, they are straining the ability of doctors to provide the best course of treatment for their patients. We are hearing directly from impacted hospitals urging immediate action to address ...
- Source: https://endpts.com/
- 120
- May 27, 2023

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