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AbbVie Completes Acquisition of Mitokinin

Addition strengthens neuroscience pipeline, company says. Image Credit: Adobe Stock Images/chinnarach AbbVie announced that it has exercised its exclusive right and completed the acquisition of Mitokinin, a biotech company focused on developing treatments for Parkinson’s disease. Under terms of the acquisition, AbbVie will pay Mitokinin shareholders $110 million at closing for the acquisition of Mitokinin, with shareholders remaining eligible for potential additional payments of up to $545 million upon the achievement of certain development and commercial milestones related to Pink1, Mitokinin’s lead compound designed to address mitochondrial dysfunction that is believed to be a major contributing factor to Parkinson’s disease pathogenesis and progression. “Parkinson’s disease continues to be a major unmet medical need, impacting patients, caregivers and society. With this acquisition, we are excited to grow our neuroscience portfolio and explore a potential new treatment option for PD,” said Jonathon Sedgwick, PhD, VP, global head of discovery research, AbbVie. “While ...
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- October 9, 2023
GE HealthCare launches AI-enhanced point-of-care ultrasound

BY SEAN WHOOLEY Caption Guidance on the Venue Go system in use. [Image courtesy of GE HealthCare] GE HealthCare (Nasdaq: GEHC)+ announced today that it launched its Venue point-of-care ultrasound systems with AI-driven Caption Guidance. Chicago-based GE HealthCare says the Venue family is the first of its ultrasound guidance to include Caption Guidance. The company added the AI-driven imaging guidance to its arsenal when it acquired Caption Health earlier this year. Caption Guidance, an optional add-on, offers new capabilities at the point of care with diagnostic-quality cardiac images. It supports clinicians in a wide range of clinical settings, like emergency departments, critical care wards and anesthesiology. GE HealthCare says the Caption Guidance technology offers clinicians step-by-step instructions to acquire ultrasound for cardiac assessments. It helps providers — even those who aren’t ultrasound experts — by addressing training and skill barriers to ultrasound usage. This, in turn, expands ultrasound access. According ...
- Source: drugdu
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- October 9, 2023
Nanobiotix shares promising results for radiotherapy enhancer in advanced pancreatic cancer

Nanobiotix has shared positive new data from an early-stage study evaluating a drug designed to enhance the efficacy of radiotherapy in patients with locally advanced pancreatic cancer. Results from the phase 1 study of NBTXR3, which is being conducted as part of an ongoing collaboration between Nanobiotix and the University of Texas MD Anderson Cancer Center, were presented at this year’s American Association for Cancer Research Special Conference on Pancreatic Cancer. Pancreatic ductal adenocarcinoma (PDAC) is associated with a poor prognosis and remains one of the leading causes of cancer-related death worldwide. For more than 90% of patients with locally advanced disease who are not eligible for surgery, there are few treatment options with curative intent, and the five-year overall survival rate for patients with unresectable PDAC remains less than 5%. Radiotherapy is one of the most common treatment modalities for cancer, with approximately 50% of patients undergoing it at ...
- Source: drugdu
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- October 9, 2023
‘Extremely concerning’ chemo shortage persists despite FDA’s efforts, national cancer group reports

While the White House recently touted the FDA’s efforts to mitigate the ongoing chemotherapy shortage in the U.S., a recent survey by the National Comprehensive Cancer Network (NCCN) shows that many treatment centers do not have enough supply of key medicines.、 NCCN surveyed 29 of its member institutions throughout the month of September and found that 72% of centers are still experiencing a carboplatin shortage, while 59% are short on cisplatin. The report is a follow-up to a June survey evaluating supply levels of the key platinum-based chemotherapies carboplatin and cisplatin. The June survey showed that 93% of centers were experiencing a carboplatin shortage, while 70% were low on cisplatin. “It is extremely concerning that this situation continues despite significant attention and effort over the past few months,” NCCN’s CEO Robert Carlson, M.D., said in a statement. “We need enduring solutions in order to safeguard people with cancer and address ...
- Source: drugdu
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- October 9, 2023
Emergex and VIC to develop infectious disease therapies in the Gulf

Emergex Vaccines has signed a Memorandum of Understanding (MoU) with the Vaccine Industrial Company (VIC) to develop and commercialise T cell-priming immune set-point candidates against infectious disease therapies. The territories included in the agreement were Saudi Arabia and other specified territories, such as GCC member states (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and UAE), other Middle Eastern territories and specified regions. As per the deal, VIC will have an equity share in Emergex, contingent on the Saudi Arabian government’s support for Phase II/III clinical trials of Emergex’s T cell-priming candidates. These are beings studied for dengue, Covid-19, and others, including the add-on therapies related to these indications. In June, Emergex reported positive data from the Phase I trial of its T cell-priming immune set-point candidate, DengueTcP, for treating dengue. The results showed that the therapy was well tolerated in healthy volunteers. The company also reported positive data for CoronaTcP, a ...
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- October 9, 2023
Ocular launches ocular implant trial to combat macular degeneration

US biopharmaceutical firm, Ocular Therapeutix has announced the start of its first clinical trial of an intravitreal eye implant intended to combat macular degeneration. Named OTX-TKI, the axitinib intravitreal implant is intended to treat wet age-related macular degeneration (wet AMD). Alongside the announcement the company has requested a Special Protocol Assessment (SPA) from the US Food and Drug Administration (FDA) as to how the trial is designed. Overall, the trial will recruit approximately 300 evaluable wet AMD patients. Antony Mattessich, CEO of Ocular Therapeutix said: “With the activation of our first clinical site in the US, we believe we are on target to enrol our first subject before year-end. “The trial is a crucial step forward for our clinical program as we make progress toward our goal of bringing a transformative new treatment that can truly make a difference for wet AMD to patients coping with vision loss.” The company ...
- Source: drugdu
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- October 9, 2023
Meet Drugdu.com at CPhI Barcelona 2023!

From October 24th to 26th, 2023, the world-renowned pharmaceutical trade show – CPhI Barcelona will once again open its doors to the elites of the global pharmaceutical industry. It’s a platform that showcases new technologies, advanced equipment, and innovative products. Drugdu.com – Your Trusted Partner As a global B2B online platform dedicated to the pharmaceutical industry, Drugdu.com will also be participating in this grand event. Our booth is located at Hall 2 / 2Y01. We warmly invite you to visit us. Why should you visit our booth? Global Exposure: Display your brand and products to a worldwide audience. Potential Business Opportunities: Explore and unlock collaboration opportunities with various potential buyers and suppliers. National Agent Recruitment: If you are a manufacturer looking for overseas agents or distributors, we can help you find the right partner. One-stop Digital Marketing: Learn how to promote your products and brand more effectively. Authoritative Industry Accreditation: ...
- Source: drugdu
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- October 9, 2023
Hospitals Turn to Backup Power When Extreme Weather Hits Propane Generators Offer Clean Solution

Summer 2023 saw an increase in patients seeking treatment for heat-related illnesses. States in the South, West, and Midwest grappled with unrelenting heat waves that made it difficult to survive without air conditioning. Northeastern states were flooded by heavy rainstorms. In addition, Canadian wildfires blanketed several U.S. states with dangerous levels of smog, making it difficult to breathe. I was in New York City in early June, and I couldn’t see the skyline for two days. Walking outside made my eyes burn and my nose run. I imagine it was much worse for those with pre-existing respiratory conditions. These extreme weather conditions and others will continue to drive up demand for electricity in nearly every state, which will strain the electric grid at the same time that older power plants are being taken offline. This combination recently prompted the North American Electric Reliability Corporation to project that two-thirds of North ...
- Source: drugdu
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- October 8, 2023
FDA says Philips’ testing of recalled devices is inadequate

Dive Brief The Food and Drug Administration called for further testing by Philips to evaluate the risks of soundproofing foam used in its recalled sleep apnea machines and ventilators. “We do not believe that the testing and analysis Philips has shared to date are adequate to fully evaluate the risks posed to users from the recalled devices,” Jeff Shuren, director of the FDA’s Center for Devices and Radiological Health, said in a Thursday statement that included more details on the recall and the agency’s actions. Philips has claimed use of the devices is “not expected to result in appreciable harm to health in patients,” but agreed with the FDA’s recommendations to run additional testing. Dive Insight Philips’ recall of sleep apnea devices and ventilators has continued since June 2021, when the company began an effort to repair or replace millions of devices that used polyester-based polyurethane (PE-PUR) foam for soundproofing. ...
- Source: drugdu
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- October 8, 2023
Merck’s Keytruda Poised for Bladder Cancer Expansion with New Phase III Data

Merck on Thursday reported that its blockbuster PD-1 inhibitor Keytruda (pembrolizumab) met one of its dual primary endpoints in the Phase III AMBASSADOR trial in muscle-invasive urothelial carcinoma. Details of the study were limited but Merck said that at a pre-specified interim analysis review Keytruda treatment led to a statistically significant and clinically meaningful improvement in disease-free survival compared with simple observation. AMBASSADOR is ongoing and will continue to assess the effects of Keytruda on overall survival (OS), the study’s second primary endpoint. The promising initial data from AMBASSADOR point to the “potential of Keytruda to prevent recurrence” in patients who had undergone surgery, Marjorie Green, senior vice president and head of late-stage oncology, global clinical development at Merck Research Laboratories, said in a statement. AMBASSADOR, also known as KEYNOTE-123, is a randomized and open-label study enrolling approximately 740 patients with localized muscle-invasive or locally advanced urothelial carcinoma. Pembrolizumab was ...
- Source: drugdu
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- October 8, 2023

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