If you have type 2 diabetes, drinking more coffee, tea or plain water may lower your risk of dying prematurely from any cause by about 25%, a new study found. However, drinking more sugar-sweetened beverages raised the risk of heart disease by 25% and the risk of dying from a heart attack or another cardiovascular event by 29%, the study said. Research has shown cardiovascular disease is the most common cause of death for people with type 2 diabetes. “Certain beverages are absolutely more beneficial than others, depending on which type of beverage you’re comparing,” said study author Qi Sun, an associate professor of nutrition and epidemiology at the Harvard T.H. Chan School of Public Health in Boston. “Based on our study I would rank black coffee, unsweetened tea and plain water higher than low-fat milk, fruit juice or artificially sweetened beverages,” he said. “Sugar-sweetened beverages like ...
Collaboration will further boost its promising pipeline of cancer treating therapies NeoPhore – a company focused on small molecule neoantigen immuno-oncology – has announced that it is collaborating with Professor Chris Lord’s lab at The Institute of Cancer Research (ICR) in London. Under the terms of the agreement, the lab will use NeoPhore’s proprietary small molecule inhibitors of DNA mismatch repair (MMR) to explore single agent activity amid tumours with defined genetic backgrounds. Meanwhile, its promising MMR modulators have the ability to induce neoantigen expression and increase immunogenicity in solid tumours that become sensitive to immunotherapy. The collaboration will further develop NeoPhore’s discoveries and ongoing research, while boosting its pipeline of cancer treating therapies. It also becomes the fourth partnership established by NeoPhore during the past six years, having also made reached agreements with St George’s University of London, Memorial Sloan Kettering Cancer Center and ...
A team led by UT Southwestern Medical Center researchers has discovered a protein that appears to be pivotal for traumatic heterotopic ossification (HO), a condition in which bone forms in muscles, tendons, and other soft tissues after traumatic injury or surgery. The findings, published in Science Advances, could yield new ways to prevent this common complication, the researchers say. “Right now, we have no ways to prevent HO from occurring, which can cause significant impairments in quality of life. For example, it can alter patients’ range of motion, producing chronic pain, and affect the ability of amputees to fit into prostheses,” said Benjamin Levi, M.D., Associate Professor of Surgery and Plastic Surgery, and Chief of the Division of Burn, Trauma, Acute, and Critical Care Surgery at UT Southwestern. “Hopefully, these new findings will lead to treatments that can stop this process from unfolding so patients never develop it.” HO occurs when cells ...
Researchers at UC Davis are the first to report how a specific type of brain cells, known as oligodendrocyte-lineage cells, transfer cell material to neurons in the mouse brain. Their work provides evidence of a coordinated nuclear interaction between these cells and neurons. The study was published today in the Journal of Experimental Medicine. “This novel concept of material transfer to neurons opens new possibilities for understanding brain maturation and finding treatments for neurological conditions, such as Alzheimer’s disease, cerebral palsy, Parkinson’s and Huntington’s disease,” said corresponding author Olga Chechneva. Chechneva is an assistant project scientist at UC Davis Department of Biochemistry and Molecular Medicine and independent principal investigator in the Institute for Pediatric Regenerative Medicine at Shriners Children’s Northern California. What are oligodendrocyte-lineage cells? Oligodendrocyte-lineage cells, also called oligodendroglia, are a type of glial cells found in the central nervous system. From birth onward, these glial cells arise to support neural ...
The US National Institute on Aging is moving forward with efforts to build a real-world Alzheimer’s disease database as part of its aim to improve, support and conduct more dementia research. Last month, the agency, part of the National Institutes of Health, posted a notice of the grant for the six-year database project, setting its earliest start date as April 2024. The NIH confirmed Tuesday that plans are underway to fund the Alzheimer’s disease and Alzheimer’s disease-related dementias’ real-world data platform. The National Institute on Aging intends to commit $50 million per year, starting in fiscal year 2024, to fund one award. The nonprofit Alzheimer’s Association is among those planning to apply for the grant. “The newly-announced NIA funding for a large-scale Alzheimer’s disease research database is truly exciting and a very important step forward for our field, and the Alzheimer’s Association will apply for ...
Most patients who are admitted to hospitals with acute viral infections are given antibiotics by their doctors or health care providers as a precaution against bacterial co-infection. Yet new research suggests this practice may not improve their survival rates. Researchers investigated the impact of antibiotic use on survival in more than 2,100 patients in a hospital in Norway between the years 2017 and 2021, Reuters reported. ‘SILENT PANDEMIC’ WARNING FROM WHO: BACTERIA KILLING TOO MANY PEOPLE DUE TO ANTIMICROBIAL RESISTANCE The researchers found that giving antibiotics to people with common respiratory infections was unlikely to lower the risk of death within 30 days. At the height of the COVID-19 pandemic, antibiotics were prescribed for around 70% of COVID-19 patients in some countries, Reuters also said. This potentially has contributed to the scourge of antibiotic-resistant pathogens known as superbugs. The new data has not been published in a medical journal ...
Depression is a common and debilitating mental illness that affects millions of people worldwide. While there are several effective treatments for depression, many patients do not respond to these treatments or experience side effects. A recent study published in the journal Nature Communications has identified a potential new drug target for treating depression. The researchers focused on a protein called L-type calcium channel α1D, which plays a key role in the regulation of mood-related behaviors. Using a mouse model of depression, the researchers found that blocking the activity of this protein led to an improvement in depressive symptoms. They also found that the protein was overactive in the brains of depressed mice and in post-mortem brain tissue from people with depression. The lead author of the study, Dr. Jian Feng, said that the results were “exciting” and showed that targeting this protein could be a promising new approach to treating ...
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