Search Results for “research” – Page 12 – media

Researchers Report on Inhibitory Effect of Glioblastoma Signals to Macrophages

Glioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0 “Don’t eat me,” is how one might translate the signal that the cancer cells in a glioblastoma send to the macrophages (white blood cells specialized in removing dead and dying cellular matter) in the brain. Immunotherapy attempts to enable these cells to eradicate the abnormal cells, but so far, it has met with little success when it comes to glioblastomas. Researchers led by Professor Gregor Hutter from the Department of Biomedicine at the University and University Hospital Basel have recently used patient data, experiments with mice, and samples from human tumors to study one of these “don’t eat me” signals and its inhibitory effect. Their findings, which may pave the way for effective immunotherapies for glioblastomas, are now being published in Science Translational Medicine. The signal is based on sugar molecules called sialic acid glycans on the surface of the cancer cells. These sugar molecules are ...
- Source: drugdu
- 126
- July 21, 2023
Researcher reach milestone in the treatment of anemia in chronic lymphocytic leukemia

In people with myelodysplastic neoplasms (MDS), a usually benign form of chronic lymphocytic leukemia, the body produces too few functional blood cells. Affected individuals suffer from anemia—a lack of red blood cells or hemoglobin—which can be a precursor to acute leukemia. Compared to the standard treatment, luspatercept can increase hemoglobin levels in MDS patients and help them to avoid blood transfusions. These are the findings of an international clinical trial led by Professor Uwe Platzbecker from Leipzig University and the University of Leipzig Medical Center in collaboration with a large international research team. Every year, around 4,000 people in Germany alone are diagnosed with myelodysplastic neoplasms (MDS). In these patients, the healthy maturation of blood cells is disrupted, which can lead to anemia, infections and an increased risk of bleeding. High-risk MDS is characterized by rapid progression, severe symptoms and often a transition to acute leukemia that results in a ...
- Source: drugdu
- 103
- July 6, 2023
Researchers discover new weapon against antibiotic resistance—it also fights malaria

Florida International University scientists discovered the first and only known natural arsenic-containing antibiotic to fight antibiotic resistance. Now, research reveals it can stop transmission of a deadly disease spreading in the U.S. for the first time in 20 years: malaria. A team from FIU’s Herbert Wertheim College of Medicine developed arsinothricin (AST) to combat the rise of antibiotic-resistant bacteria. Lab tests proved AST effectively defeated the most notorious, including E. coli and Mycobacteria, which cause tuberculosis. Collaborating with malaria researchers in the College of Arts, Sciences & Education, they’ve recently also found AST prevents Plasmodium falciparum, the parasite that causes malaria, from infecting mosquitoes—unlike other current antimalarial drugs. The discovery, recently published in Microorganisms, paves the way for AST to one day be developed into a more effective antimalarial drug for humans. “Current antimalarials don’t completely stop transmission, meaning patients can continue to infect mosquitoes before they recover,” said lead ...
- Source: drugdu
- 117
- July 4, 2023
Psylo signs research deal with Daiichi Sankyo for psychiatric therapies

Biotech start-up Psylo and Daiichi Sankyo have signed a sponsored research deal to advance the development of non-hallucinogenic psychiatric therapies. The therapies will be developed as new antidepressants for patients suffering from chronic mental illness. The biotech company will use its knowledge of neuropsychiatric therapies and the experience of Daiichi Sankyo in drug discovery and clinical development to advance the new therapies’ research and development. Psylo CEO Josh Ismin stated: “We are thrilled to receive support from Daiichi Sankyo in our mission to develop new and effective treatments for chronic mental illness. “This sponsorship represents a step forward in our efforts to harness the therapeutic potential of compounds to address mental health challenges.” The company develops next-generation therapeutics inspired by a new class of neuropsychiatric compounds. It also plans to open a new office at the B+labs incubation space in Philadelphia, Pennsylvania, US. This will provide Psylo with access to ...
- Source: drugdu
- 181
- June 26, 2023
World Health Organization publishes research agenda for antimicrobial resistance

The World Health Organization (WHO) has published its first global research agenda for scientists to address the ‘most urgent’ human health priorities to tackle antimicrobial resistance (AMR), which has been declared by the organisation as one of the top ten threats to global public health. Associated with the deaths of 4.95 million people in 2019, AMR occurs when bacteria, viruses, fungi and parasites change and adapt to antibiotics over time. As a result, infections become harder to treat, and the risk of disease spread, severe illness and death increases. The WHO Global Research Agenda for AMR in human health outlines 40 research topics on drug-resistant bacteria, fungi and Mycobacterium tuberculosis that the organisation said “must be answered by 2030”. WHO said the aim of the agenda is to guide key stakeholders, including policymakers, researchers and funders, in generating new evidence to inform AMR policies and interventions as part of efforts ...
- Source: drugdu
- 107
- June 26, 2023
Research reveals a potential gap in recommended care for people with obesity and overweight

By being undiagnosed or untreated, a significant fraction of people with obesity or overweight are not getting the recommended care, despite an increase in new treatment options, according to research being presented on June 17 at ENDO 2023, the Endocrine Society’s annual meeting in Chicago, Ill. “The number of people with obesity is high and rising in the adult U.S. population. Obesity is a complex and expensive disease that has been implicated in many chronic conditions including high blood pressure, diabetes, and cardiovascular diseases,” said Kyrian Ezendu, Ph.D., an Eli Lilly and Company advisor on benefit-risk research. “Medications to treat obesity are an integral part of long-term care for people with excess weight and are recommended for people with obesity or people with overweight and at least one obesity-related condition.” Ezendu and colleagues used data from linked electronic health records and insurance claims of people ages 18 to 80 years ...
- Source: drugdu
- 257
- June 20, 2023
New research shows illusions are in the eye, not the mind’s neurons

Numerous visual illusions are caused by limits in the way our eyes and visual neurons work—rather than more complex psychological processes, new research shows. Researchers examined illusions in which an object’s surroundings affect the way we see its color or pattern. The paper, published in the journal PLOS Computational Biology, is titled “A model of color appearance based on efficient coding of natural images.” Scientists and philosophers have long debated whether these illusions are caused by neural processing in the eye and low-level visual centers in the brain, or involve higher-level mental processes such as context and prior knowledge. In the new study Dr. Jolyon Troscianko, from the University of Exeter, co-developed a model that suggests simple limits to neural responses—not deeper psychological processes—explain these illusions. “Our eyes send messages to the brain by making neurons fire faster or slower,” said Dr. Troscianko, from the Center for Ecology and Conservation ...
- Source: drugdu
- 106
- June 17, 2023
Canadian Institutes of Health Research selects Altmetric and Dimensions from Digital Science’s flagship products

Digital Science, a technology company serving stakeholders across the research ecosystem, is pleased to announce that the Canadian Institutes of Health Research (CIHR) has chosen Altmetric and Dimensions from Digital Science’s flagship products to support its belief that research has the power to change lives. CIHR – the Government of Canada’s health research investment agency, which funds world-class research across the country – has signed a single-year deal to utilize Altmetric Explorer for Institutions and Dimensions Analytics (with API), which enables customers to monitor and report on the online activity surrounding research published by an institution, while also benefiting from access to the full Altmetric database. Using Digital Science’s products and tools, CIHR will be able to monitor the online activity surrounding academic research, including the ability to browse by author, group or department for the institution, benchmark against peer organizations, report on the outcomes of outreach activity, and integrate ...
- Source: drugdu
- 109
- June 16, 2023
Researchers identify microRNAs associated with a weakened immune response to COVID-19

A team of researchers at NYU Abu Dhabi, led by Associate Professor of Biology Youssef Idaghdour and working in collaboration with clinicians at several Abu Dhabi hospitals, investigated the association between microRNAs, a class of small RNA molecules that regulate genes, and COVID-19 severity among 259 unvaccinated COVID-19 patients living in Abu Dhabi. The team identified microRNAs that are associated with a weakened immune response and admission to ICU. During this process, they created the first genomic picture of the architecture of blood microRNAs in unvaccinated COVID-19 patients from the Middle East, North Africa, and South Asia regions whose populations are consistently underrepresented in genomics research. The researchers identified changes in microRNAs at the early stages of infection that are associated with specific blood traits and immune cell death, allowing the virus to evade the immune system and proliferate. The results of the system’s genetics study demonstrate that a patient’s ...
- Source: drugdu
- 115
- June 13, 2023
Researchers uncover new insights into why individuals are affected differently by COVID-19 infection

A team of researchers at NYU Abu Dhabi, led by Associate Professor of Biology Youssef Idaghdour and working in collaboration with clinicians at several Abu Dhabi hospitals, investigated the association between microRNAs, a class of small RNA molecules that regulate genes, and COVID-19 severity among 259 unvaccinated COVID-19 patients living in Abu Dhabi. The team identified microRNAs that are associated with a weakened immune response and admission to ICU. During this process, they created the first genomic picture of the architecture of blood microRNAs in unvaccinated COVID-19 patients from the Middle East, North Africa, and South Asia regions whose populations are consistently underrepresented in genomics research. The researchers identified changes in microRNAs at the early stages of infection that are associated with specific blood traits and immune cell death, allowing the virus to evade the immune system and proliferate. The results of the system’s genetics study demonstrate that a patient’s ...
- Source: drugdu
- 106
- June 13, 2023

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