Search Results for “cancer” – Page 134 – media

BioNTech & InstaDeep launch AI innovation lab for next-generation vaccines and biopharmaceuticals

BioNTech and InstaDeep are creating a joint AI innovation lab in Europe to develop novel immunotherapies. “We see a significant opportunity at the intersection of AI and immunology by computational design of new precision immunotherapies,” says BioNTech. One of the key research areas will be the development of next generation vaccines and biopharmaceuticals – including for COVID-19 – as well as for the treatment of cancer and prevention and therapy of infectious diseases. The partnership between Mainz-headquarted BioNTech (which is collaborating with Pfizer on one of the leading mRNA-based COVID-19 vaccine candidates) and London-based InstaDeep will create a joint AI innovation lab between the two cities. The lab will advance a portfolio of initiatives across drug discovery and design, protein engineering, manufacturing and supply chain optimization. Founded in 2014, InstaDeep has already developed collaborations in the global AI ecosystem: such as Google DeepMind, Nvidia and Intel. It was nominated by CB ...
- Source: drugdu
- 410
- November 28, 2020
vaccine
Natural products and herbal medicines show promise in fight against COVID-19

Researchers in China and the United States have called for more research into the potential prophylactic effects of natural products and herbal medicines on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent coronavirus disease 2019 (COVID-19). In an article recently published in the journal Frontiers in Pharmacology, the team discussed natural products that have exhibited an inhibitory effect on SARS-CoV-2 and herbal medicines that have been tested as potential therapies for COVID-19. “In this review, we aimed to provide a new perspective regarding COVID-19 prevention,” writes Jia-xu Chen from Jinan University in Guangzhou, and colleagues from the University of Houston, and the University of California. The researchers suggest that while the world awaits effective treatments and a commercially available vaccine, the repurposing of natural products and herbal medicines as prophylactics represents a promising approach to at least slow the transmission of SARS-CoV-2. “In the interest of public health, this ...
- Source: drugdu
- 1,337
- November 18, 2020
Covid-19
PFIZER AND BIONTECH ANNOUNCE VACCINE CANDIDATE AGAINST COVID-19 ACHIEVED SUCCESS IN FIRST INTERIM ANALYSIS FROM PHASE 3 STUDY

Monday, November 09, 2020 – 06:45am Vaccine candidate was found to be more than 90% effective in preventing COVID-19 in participants without evidence of prior SARS-CoV-2 infection in the first interim efficacy analysis Analysis evaluated 94 confirmed cases of COVID-19 in trial participants Study enrolled 43,538 participants, with 42% having diverse backgrounds, and no serious safety concerns have been observed; Safety and additional efficacy data continue to be collected Submission for Emergency Use Authorization (EUA) to the U.S. Food and Drug Administration (FDA) planned for soon after the required safety milestone is achieved, which is currently expected to occur in the third week of November Clinical trial to continue through to final analysis at 164 confirmed cases in order to collect further data and characterize the vaccine candidate’s performance against other study endpoints This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201109005539/en/ NEW YORK & MAINZ, GERMANY–(BUSINESS WIRE)– Pfizer Inc. (NYSE: ...
- Source: drugdu
- 1,237
- November 10, 2020
Covid-19 Pfizer
Long non-coding RNA CASC9 promotes gefitinib resistance in NSCLC by epigenetic repression of DUSP1

Abstract Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, has greatly affected clinical outcomes in non-small cell lung cancer (NSCLC) patients. The long noncoding RNAs (lncRNAs) are known to regulate tumorigenesis and cancer progression, but their contributions to NSCLC gefitinib resistance remain poorly understood. In this study, by analyzing the differentially expressed lncRNAs in gefitinib-resistant cells and gefitinib-sensitive cells in the National Institute of Health GEO dataset, we found that lncRNA CASC9 expression was upregulated, and this was also verified in resistant tissues. Gain and loss of function studies showed that CASC9 inhibition restored gefitinib sensitivity both in vitro and in vivo, whereas CASC9 overexpression promoted gefitinib resistance. Mechanistically, CASC9 repressed the tumor suppressor DUSP1 by recruiting histone methyltransferase EZH2, thereby increasing the resistance to gefitinib. Furthermore, ectopic expression of DUSP1 increased gefitinib sensitivity by inactivating the ERK pathway. Our results highlight the essential role ...
- Source: drugdu
- 433
- November 3, 2020
RNA CASC9
Bayer to acquire Asklepios Bio in foray into gene therapy worth up to $4 billion

By Ludwig Burger FRANKFURT (Reuters) – Bayer <BAYGn.DE> agreed to acquire unlisted U.S. biotech firm Asklepios BioPharmaceutical Inc for as much as $4 billion in a bet on gene therapy with the help of modified viruses. Germany’s Bayer will pay $2 billion upfront and up to an additional $2 billion in milestone payments contingent on development achievements, it said on Monday. The North Carolina-based takeover target, also known as AskBio, is trying to use the harmless adeno-associated virus as a delivery device to bring genetic repair kits against a range of diseases into the body.Drugs and farming pesticides maker Bayer needs to upgrade its drug development pipeline amid a weaker outlook for agricultural sales and as it seeks to finalise an $11 billion settlement over claims its Roundup weedkiller causes cancer. Among AskBio’s most advanced projects are early tests on volunteers of prospective treatments against Pompe disease – a ...
- Source: drugdu
- 280
- November 2, 2020
Gene therapy
Antiviral Used to Treat Coronavirus in Cats Very Likely to Be Effective Drug for COVID-19 Patients

By HospiMedica International staff writers Posted on 31 Aug 2020 A drug used to cure a deadly disease caused by a coronavirus in cats is expected to prove equally effective as a treatment for humans against COVID-19. Researchers at the University of Alberta (Edmonton, Alberta, Canada) are now preparing to launch clinical trials of the drug which is a protease inhibitor that interferes with the virus’s ability to replicate, thus ending an infection. Proteases are key to many body functions and are common targets for drugs to treat everything from high blood pressure to cancer and HIV. First studied by the University of Alberta researchers following the 2003 outbreak of severe acute respiratory syndrome (SARS), the protease inhibitor was further developed by veterinary researchers who showed it cures a disease that is fatal in cats. The team synthesized the compounds and tested them against the SARS-CoV-2 virus in test ...
- Source: https://www.hospimedica.com/covid-19/articles/294784252/antiviral-used-to-treat-coronavirus-in-cats-very-likely-to-be-effective-drug-for-covid-19-patients.html
- 182
- September 1, 2020
AZ’s Farxiga Gets FDA Priority Review For Heart Failure

AstraZeneca has got off to a strong start in 2020, with the FDA granting a fast review for its diabetes drug Farxiga in heart failure and China approving Lokelma for hyperkalemia.
- Source: https://scrip.pharmaintelligence.informa.com/SC141424/AZs-Farxiga-Gets-FDA-Priority-Review-For-Heart-Failure
- 1,394
- January 8, 2020
AstraZeneca Farxiga FDA Lokelma
How Central, East Africa’s tech renaissance is shaping its healthcare future

Link：https://www.mobihealthnews.com/content/how-central-east-africas-tech-renaissance-shaping-its-healthcare-future
- Source: drugdu
- 912
- June 4, 2019
Africa EHRs healthcare
Could a Third Person Be Cured of HIV?

A U.K. man may be cured of HIV comes the announcement that a man in Germany may also be HIV-free thanks to a similar treatment
- Source: https://www.livescience.com/64938-hiv-cure-third-patient.html
- 633
- March 29, 2019
bone marrow genetic mutation. HIV
Metabolic Changes in Aging Cells

Aging is caused by the deterioration of various cellular organelles and physiological processes. The pathways elements that are affected during ageing include insulin resistance, changes in body composition, decline in growth hormone, insulin-like growth factor, and sex steroids.
- Source: https://www.news-medical.net/life-sciences/Metabolic-Changes-in-Aging-Cells.aspx
- 396
- February 15, 2019
Aging Cells

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