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NIHR and Diabetes UK invest nearly £3m to prevent and treat diabetes distress

The National Institute for Health and Care Research (NIHR) and Diabetes UK have partnered, investing nearly £3m, to develop research to treat and prevent type 1 diabetes (T1D) distress. The new funding, awarded to Professor Jackie Sturt at King’s College London, will help to test a new programme known as ‘D-Stress’ to help tackle the overwhelming burden for adults living with the chronic condition. According to Diabetes UK, around 4.4 million people in the UK are living with diabetes, a metabolic disease characterised by elevated levels of blood glucose. Occurring when the pancreas does not produce insulin or makes very little insulin, T1D accounts for approximately 10% of diabetes cases in the UK and almost 50% of adults living with the condition experience high levels of diabetes distress. The new programme aims to deliver care within the NHS for the detection, prevention and management of T1D in adults and will ...
- Source: drugdu
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- July 18, 2024
Trial finds over-the-counter nasal sprays could reduce RTIs and antibiotic use

A new trial led by researchers from the University of Southampton in partnership with the University of Bristol has revealed that over-the-counter nasal sprays could help to reduce upper respiratory tract infections (RTIs), as well as the use of antibiotics. The study, published in the Lancet Respiratory Medicine and funded by the National Institute for Health and Care Research, found that nasal sprays could prevent severe symptoms of RTIs from developing. Affecting one in five people in England, RTIs are infections of parts of the body involved in breathing, including the sinuses, throat, airways or lungs. Affecting the upper areas of the respiratory system, such as the sinuses and throat, upper respiratory infection symptoms include a runny nose, sore throat and cough. Researchers analysed data from nearly 14,000 adults from 322 GP practices who experienced health problems or risk factors for infections that included either two existing health problems, a ...
- Source: drugdu
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- July 18, 2024
Accounting Standards Committee of the Ministry of Finance Visited Fosun Pharmaceuticals to Conduct Research on Equity Method Project

Recently, Mr. Zhang Juan, Deputy Director of Accounting Standards Committee of the Ministry of Finance, and his team visited Fosun Pharmaceuticals’ Shanghai headquarters to conduct a special investigation on the equity method project, and Mr. Sun Mei, Partner of Ernst & Young’s Technology Department, participated in the investigation together. The research centered on the equity method project being carried out by the International Accounting Standards Board (IASB), and included research and exchanges on the practical application of the equity method on the enterprise side. Mr. Guan Xiaohui, Executive Director and Vice Chairman of Fosun Pharma, welcomed the delegation of the Accounting Standards Committee of the Ministry of Finance and believed that this exchange would help to improve the quality of the company’s accounting information and further understanding of accounting standards. Mr. Guan indicated that Fosun has always attached great importance to the compliance of financial information disclosure, and has continuously ...
- Source: drugdu
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- July 18, 2024
Nature Medicine publishes latest results of combination chemotherapy with Benmelstobart and anlotinib, with a median OS of 19.32 months in SCLC

On July 11, encouraging news came from the ETER701 study completed by 72 centers nationwide led by Professor Cheng Ying of Jilin Cancer Hospital. The academic paper Benmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial was published online in the international authoritative medical journal Nature ETER701 was a study of Chiatai Tianqing’s Benmelstobart and anlotinib in combination with chemotherapy in the first-line treatment of extensive-stage small-cell lung cancer. The study showed that the median progression-free survival (mPFS) and median overall survival (mOS) of patients included in the current study were the highest in the history of the registry study, and that the combination chemotherapy regimen of Benmelstobart and amlotinib is expected to provide a survival benefit for patients with extensive-stage small cell lung cancer (ES-SCLC). This is another authoritative recognition of Benmelstobart in combination with amlotinib and chemotherapy in the field of extensive-stage small ...
- Source: drugdu
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- July 18, 2024
SOTIO Biotech, Biocytogen Ink Research and License Agreement to Develop Next-Generation Antibody-Drug Conjugates

By Don Tracy, Associate Editor The agreement enables SOTIO to license multiple fully human bispecific antibodies from Biocytogen’s RenLite platform. SOTIO Biotech, a clinical-stage biopharmaceutical company owned by PPF Group, and Biocytogen have agreed to terms on a research collaboration and exclusive option and license agreement. According to the companies, the deal will aim to develop next-generation antibody-drug conjugates (ADCs) for targeting solid tumors, while SOTIO will also have the ability to utilize Biocytogen’s proprietary ADC platform. “SOTIO’s powerful ADC platform brings together multiple technologies, allowing us to tailor our therapeutics to meet the needs of specific cancer types. Specifically, exploiting bispecific targeting in the context of our ADC approaches to improve precision targeting and overcome tumor heterogeneity is particularly appealing,” said Martin Steegmaier, PhD, chief scientific officer SOTIO, in a press release. “This agreement with Biocytogen complements our existing collaborations with Synaffix, LigaChem, and NBE-Therapeutics, providing SOTIO with access ...
- Source: drugdu
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- July 18, 2024
Tau-Focused Asceneuron Adds $100M as Oral Alzheimer’s Drug Advances to Phase 2 Trial

Novo Holdings led Asceneuron’s $100 million Series C financing. The Merck Serono spinout’s lead program is an oral small molecule designed to prevent aggregation of tau protein in neurodegenerative disorders. By Frank Vinluan Alzheimer’s disease patients can now choose between new two intravenously infused therapies that work by breaking up plaques of amyloid protein in the brain. Asceneuron takes a different approach with oral therapies that address the buildup of tau, a protein that’s also associated with the neurodegenerative disorder. The biotech now has $100 million to advance its lead program to Phase 2 testing. The Series C financing announced Tuesday was led by Novo Holdings, the company that manages the assets of the Novo Nordisk Foundation, the controlling shareholder of metabolic drug giant Novo Nordisk. Using a drug to target and break up pathological proteins associated with Alzheimer’s has been validated by Eisai’s Leqembi, approved by the FDA last year, ...
- Source: drugdu
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- July 18, 2024
AbbVie looks to add an eighth indication for JAK inhibitor Rinvoq

AbbVie is set to expand the indication list for its immunology blockbuster, Rinvoq (upadacitinib). The company has submitted applications to both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) to seek approval for the use of Rinvoq as a treatment for giant cell arteritis. Rinvoq blocks the activity of Janus kinase (JAK) enzymes in the JAK-STAT signalling pathway, which plays a role in the release of pro-inflammatory cytokines. It has been approved by the FDA to treat seven autoimmune conditions, namely atopic dermatitis, ankylosing spondylitis, axial spondylarthritis, Crohn’s disease, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. Rinvoq is one of the top revenue-generating therapies for AbbVie, raking in approximately $4bn in sales last year, per the company’s financials. The therapy’s revenue is expected to soar over the next decade, with Rinvoq expected to pull in over $12bn in sales by 2030, as ...
- Source: https://www.pharmaceutical-technology.com/news/abbvie-looks-to-add-an-eighth-indication-for-jak-inhibitor-rinvoq/
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- July 17, 2024
Delix plans further trials with neuroplastogen after positive Phase I data

Delix Therapeutics is planning to initiate two studies to evaluate patients with major depression investigating its lead neuroplastogen candidate, DLX-001, Delix CMO Dr. Aaron Koenig told Pharmaceutical Technology. Upon the completion of an ongoing Phase I study, the Bedford, Massachusetts-based biotech will take the small molecule into two planned trials—a Phase Ib study and a Phase II study, Koenig said. DLX-001 is a neuroplastogen designed to promote neuroplasticity without giving rise to the deleterious attributes of first- and second-generation psychedelics. “With many psychoactive drugs, you’re talking about the concentrations that you’re able to maintain, continuously engaging the receptor for some period of time. We think that this [DLX-001] has a Cmax-driven effect, meaning that it’s about flipping the switch on the receptor so that downstream effects can then occur,” said Koenig. In May, the company released Phase I data, which demonstrated that treatment with DLX-001 does not produce any psychedelic ...
- Source: https://www.pharmaceutical-technology.com/news/delix-plans-further-trials-with-neuroplastogen-after-positive-phase-i-data/?cf-view
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- July 17, 2024
Innovate UK grants £4m to four companies to evaluate biomarkers for dementia

The progressive neurodegenerative disease affects more than 55 million people globally Innovate UK has awarded £4m through its Contracts for Innovation to four UK companies for research into dementia diagnosis. As part of the Bio-Hermes-002 study led by the US-based Global Alzheimer’s Platform Foundation (GAP) in partnership with Novo Nordisk, the organisations will evaluate blood-based and digital innovative biomarkers for the neurological condition. Affecting more than 55 million people globally, which is expected to triple by 2050, dementia is a neurodegenerative condition that affects the ability to remember, think or make decisions in everyday life. The study aims to explore whether these biomarkers can predict the extent of tau and amyloid brain pathology and potentially provide more efficient and less invasive alternatives to the current gold standard for dementia diagnoses: positron emission tomography brain imaging. The project will involve 1,000 participants who are cognitively normal, have mild cognitive impairment or ...
- Source: https://www.ukri.org/news/uk-and-us-join-forces-to-tackle-dementia-with-innovative-biomarkers/
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- July 17, 2024
UK Researchers developing new tetanus test to identify global immunity gaps

The serious, rare condition is responsible for up to 7% of all neonatal deaths globally Researchers from the University of Birmingham are developing a new blood-free test to help identify children across the Global South missing immunity to tetanus and other essential vaccines. Supported by £1.1m of funding by the Medical Research Council, the low-cost, non-invasive saliva lateral flow test can potentially reveal whether a person has protection against tetanus within just 15 minutes. Estimated to be responsible for up to 293,000 deaths worldwide every year, according to the European Centre for Disease Prevention and Control, tetanus is a serious disease of the nervous system caused by a toxin-producing bacterium, Clostridium tetani, and is responsible for up to 7% of all neonatal deaths globally. Newborn tetanus is a rare condition that occurs in infants most often within the first ten days of life, resulting from an infection in the umbilical ...
- Source: https://pharmatimes.com/news/uk-researchers-developing-blood-free-tetanus-test-to-identify-global-immunity-gaps/
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- July 17, 2024

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