PharmaFocus Today – Page 64 – media

Arcus Biosciences obtains loan facility with Hercules Capital worth $250m

Arcus Biosciences has announced a loan from financer Hercules Capital valued at as much as $250m, contingent on the advancement of the company’s therapeutic candidates. Arcus released the news after the markets closed yesterday (27 August), outlining an initial $50m granted at the deal’s close, with another $100m available at Arcus’s discretion. Provided Hercules Capital approves, a further $100m can be drawn. The five-year loan and four-year interest-only period may each be extended another year should Arcus initiate Phase III trials for its cancer therapies, a HIF-2α inhibitor casdatifan and the CD73 inhibitor quemlicustat, and meet regulatory milestones, respectively. The deal comes as the company continues its financial recovery. Arcus’s share price dropped from a high of $49.1 in November 2021 to $13.10 in November 2023. When the market opened today (28 August), the share price stood at $17.3; the company is valued at $1.6bn. Arcus CEO Dr. Terry Rosen ...
- Source: drugdu
- 80
- August 30, 2024
Bayer teams up with lncRNA-focused NextRNA in $547m deal

Bayer has teamed up with startup biotech NextRNA Therapeutics to develop small molecules targeting long non-coding RNAs (lncRNAs) in oncology. Under the terms of the deal, NextRNA can get up to $547m if all the milestones are reached, and the deal also included an undisclosed upfront payment. The companies will collaborate on two oncology programmes, the first involving a lncRNA-targeting small molecule in early preclinical development at NextRNA. For the second, NextRNA will pursue lncRNA targets identified by its platform, with Bayer having the option to choose one target for joint development. In 2022, Dana-Farber spinout NextRNA came out of stealth with $9.3m from a seed financing round and $46.8m from a Series A. This is the first high-profile pharma deal for the startup, which focuses on lncRNA-driven diseases. lncRNAs are RNA molecules over 200 nucleotides long that regulate gene expression without coding for proteins. They play key roles in ...
- Source: drugdu
- 100
- August 30, 2024
myTomorrows and Pancreatic Cancer Europe partner on clinical trials

The partnership will improve care for patients with pancreatic cancer myTomorrows, a global health technology company connecting patients with all possible treatment options, has announced a new partnership with Pancreatic Cancer Europe, a multi-stakeholder platform that brings together experts from all over Europe to improve care for patients with pancreatic cancer. Through the new partnership, Pancreatic Cancer Europe (PCE) will utilise myTomorrows’ database of ongoing clinical trials to equip patients, caregivers and healthcare professionals (HCPs) with up-to-date, accessible information about pre-approval treatments that may be relevant to them. The partnership with the European patient advocacy group and myTomorrows will help to expand access to all possible treatment options for patients suffering from a variety of life-threatening illnesses. For pancreatic cancer patients and HCPs, the partnership will help make the process of identifying and understanding the existing clinical trial options easier. Pancreatic cancer is the fourth leading cause of cancer deaths, ...
- Source: drugdu
- 116
- August 30, 2024
Acelyrin’s izokibep for hidradenitis suppurativa reveals positive results

Acelyrin has shared positive results from a late-stage study of its IL-17A inhibitor izokibep in hidradenitis suppurativa (HS), but has said it will not be moving forward with the asset in this indication. Estimated to affect about 1% of the population in most studied countries, HS is a chronic inflammatory skin condition that causes painful nodules and abscesses. In the phase 3 trial, izokibep demonstrated statistically significant responses across multiple efficacy endpoints at week 12, with 33% of patients being treated with izokibep 160mg weekly achieving at least a 75% reduction in total abscess and inflammatory nodule count (HiSCR75) compared to 21% of those receiving placebo. Results also showed that 25% and 22% of izokibep-treated patients achieved HiSCR90 and HiSCR100, respectively, compared to 9% and 8% in the placebo cohort. The announcement comes shortly after the drug demonstrated promising results in a phase 2b/3 study for psoriatic arthritis (PsA), a ...
- Source: drugdu
- 72
- August 30, 2024
Ansukang Ultrasonic Knife completes a new round of billion yuan financing

Today (August 26th), Ansukang Medical (Suzhou) Co., Ltd. (hereinafter referred to as “Ansukang Medical”) announced the completion of a new round of 100 million yuan financing. The round of financing is jointly invested by Taiping Innovation, Junlian Capital, and Shengjing Jiacheng. The funds raised from the financing will mainly be used for promoting the market of unmanned ultrasonic knives, building a new generation of energy platforms, and preparing production capacity. Founded in 2020, Ansukang Medical has been focusing on the research and development of innovative medical devices since its establishment. It is an innovative medical device company based on its own core technology system, committed to providing Chinese medical workers with better and more convenient medical devices. At present, the main product launched by Ansukang Medical is the new generation of non host ultrasonic knife, which is also the world’s first split type non host ultrasonic knife. Compared with similar ...
- Source: drugdu
- 127
- August 29, 2024
Eli Lilly’s Zepbound to be issued in single-dose vials for self-payers

Eli Lilly and Company has announced the availability of Zepbound (tirzepatide) in 2.5mg and 5mg single-dose vials for self-pay for adults with obesity. The move significantly expands the supply of Zepbound in response to high demand and offers a more affordable option for those who self-pay. The vials are priced a minimum of 50% lower than the list price of other incretin medicines for obesity. Lilly has introduced a new self-pay pharmacy component within LillyDirect, enabling patients with a valid prescription to purchase Zepbound directly. The initiative ensures the authenticity of the medicine and safeguards patients from counterfeit products. Lilly also announced its commitment to ensuring that Zepbound is used appropriately and not for cosmetic weight loss, implementing a multi-step verification process for dispensing. The 2.5mg Zepbound vial costs $399 for a four-week supply while the 5mg dose costs $549 – both representing significant savings compared to other treatments. The ...
- Source: drugdu
- 64
- August 29, 2024
Pfizer launches digital healthcare platform to streamline access

Pfizer has launched a new digital platform, PfizerForAll, aimed at simplifying the process of accessing healthcare for millions of Americans. The platform provides an integrated experience for managing health and wellness, particularly for those affected by common illnesses and seeking adult vaccinations. PfizerForAll consolidates critical resources and services, enabling individuals and families to take health actions such as obtaining care, filling prescriptions and finding potential savings on Pfizer medicines. The platform operates within the US healthcare system and is developed in partnership with healthcare organisations. Patients using PfizerForAll can leverage their existing insurance and pharmacy programmes while benefiting from new direct services from partners such as UpScriptHealth, Alto Pharmacy and Instacart. At its inception, PfizerForAll offers same-day appointments with healthcare professionals for in-person or telehealth consultations, home delivery of prescription medicines, and scheduling for adult vaccinations against Covid-19, flu, RSV [respiratory syncytial virus] and pneumococcal pneumonia. The platform will also ...
- Source: drugdu
- 78
- August 29, 2024
MHRA approves Astellas’ Vyloy combination for gastric cancer

The Medicines and Healthcare products Regulatory Agency (MHRA) has approved Astellas Pharma’s Vyloy (zolbetuximab) as part of a first-line combination treatment for a subset of gastric cancer patients. The monoclonal antibody has been authorised for use alongside chemotherapy to treat adults with locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric or gastro-oesophageal junction (GEJ) adenocarcinoma whose tumours are claudin 18.2 positive. In the UK, adenocarcinomas, which develop from cells in the innermost lining of the stomach, account for most cases of gastric cancer, with around 6,600 people diagnosed every year. Most cases go undetected until an advanced stage, as the disease rarely causes early symptoms and tends to develop slowly over a number of years. Vyloy is now the only licensed treatment to target the claudin 18.2 protein, which is expressed in gastric, oesophageal, lung and ovarian tissues, and is administered intravenously every two to three ...
- Source: drugdu
- 68
- August 29, 2024
Improving tracking of AMR bacteria in hospitals using new genomic technique

Using a genomic approach, researchers have developed a way to simultaneously track the spread of multiple common antibiotic-resistant bacteria in hospitals. Current methods culture and sequence all pathogens separately so the new sequencing technique could help to prevent and manage hospital infections more quickly and effectively. Published in the Lancet Microbe, the proof-of-concept study from the Wellcome Sanger Institute, the University of Oslo, Fondazione IRCCS Policlinico San Matteo in Italy and collaborators captured the whole population of pathogenic bacteria found in the gut, upper airways and lungs of patients in multiple hospital intensive care units (ICUs) and ordinary wards during the first wave of the COVID-19 pandemic in 2020. The team found that, with most ICU patients colonised by several treatment-resistant bacteria and all patients colonised by at least one, they were able to determine which type of bacteria each patient had. Antimicrobial resistance (AMR) occurs when bacteria, viruses, fungi ...
- Source: drugdu
- 75
- August 29, 2024
AI-Based Digital Pathology Platform Improves Lung Cancer Diagnosis

Lung cancer ranks among the most prevalent and fatal cancers worldwide. Current treatment strategies for lung cancer patients rely on pathological examinations, which can reveal genetic mutations specific to the patient’s cancer, facilitating personalized treatment approaches. Over the last few years, pathology has evolved dramatically due to digital advancements, making traditional microscopes obsolete. Tissue samples are now digitized and analyzed via computer screens, which is essential for employing sophisticated artificial intelligence (AI)-based analytical methods. These AI technologies can extract additional insights from pathological tissue sections that were previously unattainable. A team of researchers at the University of Cologne (Cologne, Germany) has developed an AI-driven digital pathology platform that can revolutionize the analysis of lung cancer tissues. This platform utilizes newly developed algorithms to perform fully automated examination of digitized lung cancer tissue sections, offering faster and more precise analyses than traditional methods. Detailed in their publication in the journal Cell ...
- Source: drugdu
- 75
- August 28, 2024

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