The World Health Organization recently released the "2025 Global Antibiotic Resistance Monitoring Report" and warned that the problem of resistance to commonly used antibiotics is widespread around the world, and the increasing resistance to basic antibiotics poses an increasingly serious threat to global health.
The report predicts that one in six laboratory-confirmed bacterial infections causing common infections worldwide will be resistant to antibiotic treatment by 2023. Between 2018 and 2023, antibiotic resistance increased in more than 40% of monitored pathogen-antibiotic combinations, with an average annual increase of 5% to 15%.
The report, which collected data from more than 100 countries, published for the first time the data on the use of drugs for the treatment of urinary tract and gastrointestinal infections, blood flu,The report provides estimates of resistance to 22 antibiotics for infections and gonorrhea. The report covers eight common bacterial pathogens, including Acinetobacter baumannii and Escherichia coli, each of which is associated with one or more of the above infections.
The report specifically notes that drug-resistant Gram-negative bacteria are becoming increasingly dangerous worldwide. Escherichia coli and Klebsiella pneumoniae are the primary resistant Gram-negative bacteria found in bloodstream infections. These serious bacterial infections often lead to sepsis, organ failure, and death. However, globally, over 40% of E. coli and over 55% of K. pneumoniae are now resistant to the first-line treatment, third-generation cephalosporins. In the African Region, this proportion exceeds 70%.
Furthermore, the risk of antibiotic resistance varies across the world, with the highest levels in the WHO South-East Asia and Eastern Mediterranean regions, where one in three reported infections showed antibiotic resistance, and in the African Region, where one in five infections showed resistance.
“Antimicrobial resistance is outpacing advances in modern medicine, threatening the health of families worldwide,” said WHO Director-General Tedros Adhanom Ghebreyesus. “As countries strengthen their systems for antimicrobial resistance surveillance, we must use antibiotics responsibly and ensure universal access to the right medicines, quality-assured diagnostics and vaccines.”

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