media – Page 89 – Pharma & Medical Industry Insights Hub | Drugdu Insights & Updates

How a single gene reshapes pain perception through polyamine signaling

In a recent study published in the journal Nature, an international team of researchers showed that solute carrier family 45 member 4 (SLC45A4) is a pain gene that encodes a neuronal polyamine transporter. Chronic pain affects one in five adults and has an adverse effect on the quality of life. Unfortunately, available treatments are often inadequate, with poor tolerability and efficacy. Polyamines, such as spermidine, spermine, and putrescine, are regulatory metabolites reported to contribute to chronic pain. They play crucial roles in nucleic acid synthesis and stability, cell signaling, and growth. Polyamines are implicated in neurological disorders, such as stroke and epilepsy. They can regulate neuronal excitability through ion channel interactions and have been linked to pain. Polyamines exhibit altered levels in pain states in humans and modulate pain behavior in animal models. Nevertheless, the systems influencing polyamine transport in the nervous system remain unclear. The study and findings In ...
- Source: drugdu
- 134
- August 25, 2025
Flu Shot Season is At Hand

By Carole Tanzer Miller HealthDay ReporterSATURDAY, Aug. 23, 2025 (HealthDay News) — With a longtime vaccine critic leading the nation’s health departments, you might be wondering whether there’s a new flu shot this fall. There is — and Health and Human Services Secretary Robert F. Kennedy Jr. says most Americans should get it. He’s basing that recommendation on the advice of a board he appointed to advise the federal government on vaccines. The U.S. Centers for Disease Control and Prevention (CDC) says people 6 months old and up should get a flu shot. That’s pretty much the same advice the CDC has given in the past. This year’s version of the flu vaccine should be widely available soon, according to KFF Health News. No shortages are anticipated. So when should you roll up your sleeve? The best time to take the jab is September, October or early November, doctors say. ...
- Source: drugdu
- 174
- August 25, 2025
Betta Pharmaceuticals discloses clinical research progress on ensartinib for postoperative adjuvant indications

Betta PharmaceuticalsOn the morning of August 25th, the company announced that in April 2022, the National Medical Products Administration (NMPA) approved the clinical trial of Ensartinib Hydrochloride Capsules (Bemena®, hereinafter referred to as “Ensartinib”) for the adjuvant treatment of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) after surgery. Recently, an interim analysis of the clinical trial, as assessed by the Independent Data Monitoring Committee (IDMC), demonstrated positive results, meeting the study’s pre-specified primary endpoint and demonstrating statistically significant and clinically important benefits. Detailed data from this study will be presented at a major international academic conference this year. The company’s team is actively preparing application materials and aiming to submit the NDA for this new indication as soon as possible. https://finance.eastmoney.com/a/202508253492884316.html
- Source: drugdu
- 165
- August 25, 2025
How NMN Helps Longevity Enzymes Fight Aging

Sirtuin enzymes are a family of NAD+-dependent deacetylase proteins, also known as sirtuins, which mediate many of the beneficial effects of NMN on the brain and intestines of aged mice. Left: Sirtuin 1 bound to the sirtuin activator resveratrol (magenta). Right: Sirtuin 6 bound to the sirtuin activator (yellow) and NAD+ (red). Sirtuins act like molecular switches, orchestrating the countless processes necessary for cellular health and longevity. These specialized proteins function as NAD+-dependent deacetylases—enzymes that remove acetyl groups from other proteins, effectively altering their function. They regulate processes ranging from DNA repair and energy metabolism to inflammation and cellular stress responses. However, sirtuin activity naturally declines with aging. Sirtuins are particularly intriguing because of their dependence on NAD+ (nicotinamide adenine dinucleotide). This crucial coenzyme serves as the “fuel” for sirtuin activity. Unfortunately, NAD+ levels naturally decline with age, dropping by up to 50% in mammals during the transition from youth ...
- Source: drugdu
- 166
- August 25, 2025
Obtained U.S. FDA Drug Registration Approval for Nicardipine Hydrochloride Injection

SecuritiesDaily News Network reported on the evening of August 21 that Jianyou SharesThe company recently received an approval letter from the U.S. Food and Drug Administration (FDA) for nicardipine hydrochloride injection, 25mg/10mL (2.5mg/mL), according to an announcement. https://finance.eastmoney.com/a/202508213490940546.html
- Source: drugdu
- 124
- August 25, 2025
The world’s first hexavalent rotavirus vaccine is approved for marketing

Recently, Sinopharm Group China National Biotec Group Wuhan Biological ProductsThe Institute’s oral hexavalent, reassortant, live attenuated rotavirus vaccine (Vero cell-based) (trade name: Wushengerlunbao®) has been officially approved for marketing by the National Medical Products Administration. This product, the world’s first and most expensive rotavirus vaccine, is a Class 1 new biological drug for preventive use in China and is primarily used to prevent acute gastroenteritis in infants and young children caused by rotavirus https://finance.eastmoney.com/a/202508223492196812.html
- Source: drugdu
- 182
- August 25, 2025
【EXPERT Q&A】Are quality management systems in the medical device industry effective?

Drugdu.com expert’s response: The quality management system (QMS) in the medical device industry is not only valuable but also a core element in ensuring product safety and effectiveness, meeting regulatory requirements, enhancing corporate competitiveness, and promoting the healthy development of the industry. Its importance is reflected in the following aspects: Ensuring Patient Safety and Product Effectiveness Risk Control: Medical devices directly interact with the human body, and quality defects can lead to severe health risks (e.g., surgical instrument fractures, implant failures, diagnostic device misdiagnoses). The QMS reduces risks to acceptable levels through systematic risk assessments (e.g., Failure Mode and Effects Analysis, or FMEA), design controls, and production process monitoring. Performance Verification: Rigorous testing and validation (e.g., biocompatibility testing, electrical safety testing, performance stability testing) ensure that products meet their intended purposes and prevent medical accidents caused by functional failures. Meeting Global Regulatory and Compliance Requirements International Standard Mandates: Major global ...
- Source: drugdu
- 214
- August 25, 2025
【EXPERT Q&A】What are the registration and regulatory requirements that IVD test reagents for Chikungunya virus need to comply with?

Drugdu.com expert’s response: The registration and regulatory requirements for IVD test reagents for Chikungunya virus vary across different countries and regions. Below are the specific requirements for some major countries and regions: European Union Regulatory Compliance: Must comply with the In Vitro Diagnostic Medical Devices Regulation (IVDR, Regulation (EU) 2017/746). Product Classification: According to the classification rules of the IVDR, IVD test reagents for Chikungunya virus are typically classified as Class C or Class D, depending on their intended use and risk level. Review and Certification: For Class C or Class D products, review and certification by a Notified Body are required. Quality Management System: Companies must establish a quality management system that complies with the ISO 13485 standard and ensure that the product meets relevant basic requirements. Submission of Technical Documentation: Technical documentation, including product performance evaluation reports, clinical evidence, labels, and instructions, must be submitted. CE Marking and ...
- Source: drugdu
- 240
- August 22, 2025
Investigation raises concerns over tooth stem cell banking claims

Parents are spending thousands of pounds to bank stem cells from their children’s milk teeth – but the recipient companies’ claims about their future medical value are unproven and potentially misleading, reveals an investigation by The BMJ, published today. The companies’ claims include that stem cells banked from teeth are already being used in treatments for autism and diabetes. They also highlight current research using stem cells in multiple sclerosis, Parkinson’s disease, and heart attacks. Tooth stem cell banking involves parents sending their children’s lost milk teeth to a laboratory where the dental pulp stem cells are harvested and stored. The service costs around £1900 (€2189; $2573) with an additional annual storage fee of £95, explains freelance journalist Emma Wilkinson. The three companies in the UK offering tooth stem cell banking – Future Health Biobank, BioEden and Stem Protect – all operate through one laboratory. Future Health Biobank says on ...
- Source: drugdu
- 181
- August 21, 2025
Seniors Neglecting Steps To Protect Heart Health, Study Says

By Dennis Thompson HealthDay ReporterWEDNESDAY, Aug. 20, 2025 (HealthDay News) — Seniors with known heart-related problems aren’t doing a very good job taking steps to protect their health, a new study says. Older folks with high blood pressure, stroke survivors and heart failure patients in the United States all have been neglecting Life’s Essential 8 — a checklist of lifestyle factors that can protect heart health, researchers found. “On average, participants with one cardiovascular disease had a Life’s Essential 8 score 9 points lower than those without cardiovascular disease,” lead researcher James Walker, a medical student at Northwestern University in Chicago, said in a news release. Life’s Essential 8 recommends that people eat healthy, exercise, avoid smoking, sleep better, lose excess weight, and manage their cholesterol, blood sugar and blood pressure levels, according to the American Heart Association. For this study, researchers analyzed a sample of more than 3,000 adults ...
- Source: drugdu
- 147
- August 21, 2025

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