Search Results for “EC” – Page 84 – media

Glenmark solves its ‘decade-long’ debt problem with $681M sale of API unit to Nirma

By divesting 75% of its active pharmaceutical ingredient (API) business, Glenmark Pharmaceuticals has finally resolved its debt problem, described by an Indian news outlet as a “decade-long troubled affair.”The buyer is Nirma Limited, which will pay 615 Indian rupees per share, which comes to Rs 5,651 crore ($681 million) in total. Based in Ahmedabad, Nirma specializes in cosmetics, detergents, salt and injectables. In a press conference, Glenmark’s chairman and managing director Glenn Saldanha said the company was facing a gross debut of approximately Rs 4,600 crore ($555 million). “The total debt gets extinguished after the deal,” he added. In revealing (PDF) the sale, Glenmark said the deal allows it to become an innovative and brand-led company, focusing on its core therapeutic areas of dermatology, respiratory and oncology. The sale leaves the company with a 7.8% share in the API subsidiary, named Glenmark Life Sciences, which will continue to operate as ...
- Source: drugdu
- 142
- October 4, 2023
Socioeconomic status may not clearly predict the heart health of racial and ethnic groups

Improvements in socioeconomic status (education, income, employment status and health insurance) on ideal cardiovascular health may not benefit people from all racial or ethnic groups equally, as white adults were more likely to benefit than Black, Hispanic and Asian adults in the U.S., according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association. Joshua J. Joseph (M.D., M.P.H., FAHA, senior study author, associate professor of internal medicine, The Ohio State University College of Medicine in Columbus) said, “The goal of economic interventions and societal policies, such as improving employment, health care access and education, is that they will lead to improvements in health for everyone. However, our study found that improvements in these socioeconomic interventions may not benefit people in all racial or ethnic groups equally.” The researchers suggest that additional factors including psychosocial stress experienced ...
- Source: drugdu
- 242
- October 3, 2023
Once a Blockbuster Prospect, Is Travere’s Kidney Drug on Track to Become a Bust?

Seven months after Travere Therapeutics’ flagship drug received accelerated FDA approval in a rare kidney disease, the molecule has fallen short of the key goal of its confirmatory test. It’s the small molecule’s second Phase 3 failure this year. By FRANK VINLUAN A Travere Therapeutics drug that won speedy approval early this year for a rare autoimmune kidney disorder has failed to meet the key goal of its confirmatory study. Still, the biotech points to data trends favoring patients treated with its drug, Filspari, and it aims to seek full approval. But even if the FDA permits the drug to remain on the market, the disappointing trial results reported Thursday call into question the commercial prospects of a product once projected to become a blockbuster seller. Filspari was developed to treat immunoglobulin A nephropathy (IgAN), in which the buildup of antibodies in the kidneys damages these organs. The FDA awarded ...
- Source: drugdu
- 159
- October 3, 2023
Genentech, PeptiDream Ink Potential $1B Radiopharma Deal

By Kate Goodwin Pictured: Businessmen shaking hands/iStock, Tippapatt Japanese biopharma PeptiDream on Wednesday announced yet another licensing agreement with Roche’s Genentech, this time worth up to $1 billion. The latest deal builds on previous partnerships between the two companies starting in December 2015 with licensing in 2016 and an expansion deal in 2018. PeptiDream will receive $40 million upfront for R&D of its macrocyclic peptide-radioisotope drug conjugates. Going forward, another $1 billion is on the line in milestones plus tiered royalties of product sales to markets outside of Japan. PeptiDream will oversee preclinical activities to develop a peptide-RI drug conjugate and retain rights in Japan for any products developed. While a particular target was not disclosed, PeptiDream CEO Patrick Reid said in a statement that the company hopes to “bring innovative first-in-class peptide radiopharmaceuticals to patients worldwide.” The peptide-RI drug conjugates in the deal with Genentech are designed to use ...
- Source: drugdu
- 117
- September 30, 2023
NICE recommends more genetic testing for links to ovarian cancer

Around 340,000 to 444,000 people in the UK carry one of nine pathogenic gene variants The National Institute for Health and Care Excellence (NICE) has recommended that more people get tested for genes linked to ovarian cancer. The new guideline aims to raise awareness and increase the availability of genetic testing, allowing people to take preventive measures, including surgery, to prevent the development of ovarian cancer. Anyone can carry a gene linked to ovarian cancer, including women, men, transgender people, and non-binary people, which can be passed on to their children. In the UK, around 340,000 to 440,000 people carry one of the nine pathogenic variants – BRCA1, BRCA2, MLH1, MSH2, MSH6, RAD51C, RAD51D, BRIP1 and PALB2 – that cause cancer, 3% of whom know they have a high-risk gene. NICE has recommended that genetic services should test and assess the likelihood of people carrying the genes, including those who ...
- Source: drugdu
- 102
- September 30, 2023
Enovis inks $847M acquisition to boost orthopedic reconstruction business

Dive Brief Enovis has struck an agreement to buy orthopedics company LimaCorporate for 800 million Euros ($847 million). The acquisition of the Italy-based company will scale Enovis’ global reconstruction unit, creating a $1 billion business that is forecast to grow in the high single digits and generate $40 million in cost synergies over the next three years. Vik Chopra, an analyst at Wells Fargo, said the acquisition was “much larger than what we were expecting,” in a conference call with Enovis management. Shares in Enovis rose 5% to $54.16 after the Delaware-based company disclosed the deal. Dive Insight Enovis, formerly called Colfax, has grown its operations through a series of acquisitions since the start of the decade, globalizing its reconstruction business with the $285 million takeover of Mathys in 2021 and adding other assets to establish and build its foot and ankle business. “At the time [of the Mathys deal], ...
- Source: drugdu
- 101
- September 28, 2023
Morphic’s Ulcerative Colitis Pill Misses Expectations in Mid-Stage Study, Stock Falls

By Tristan Manalac Pictured: Woman grasping her stomach in pain/iStock, Doucefleur New data from the Phase IIa EMERALD-1 study showed that Morphic Therapeutic’s investigational ulcerative colitis pill MORF-057 induced endoscopic improvement, the company announced Friday. However, investors were underwhelmed with the candidate’s new efficacy findings and Morphic’s stock price dropped around 25% after the data was released. The new data, presented in a moderated poster session at the United European Gastroenterology Week (UEGW) 2023, showed that at 12 weeks, 25.7% of treated patients demonstrated endoscopic improvement. Clinical response, measured using the modified Mayo Clinic Score (mMCS), was documented in 45.7% of participants at 12 weeks. The UEGW data follow a prior readout from EMERALD-1, posted in April 2023, which showed that patients treated with MORF-057 saw a significant 6.4-point improvement in the Robarts Histopathology Index, a validated tool that measures histological disease activity in ulcerative colitis. This was accompanied by ...
- Source: drugdu
- 159
- September 27, 2023
Boston Scientific expects ‘dramatic shift’ to pulsed field ablation to fuel fast growth through 2026

Dive Brief Boston Scientific has set bullish growth targets for 2024 to 2026, according to analysts. The company is forecasting that a “dramatic shift” to pulsed field ablation will increase its organic revenues by 8% to 10% over the period. Analysts went into Boston Scientific’s investor day expecting 7% to 9% growth. Some analysts left the event speculating that Boston Scientific can exceed its 10% target after being convinced that PFA and left atrial appendage closure can power the company toward its goal. Boston Scientific forecast that the global atrial fibrillation ablation market will grow from $5 billion today to $8 billion in 2026 and $11 billion by 2028. PFA’s share of the market is predicted to rise from less than 5% today to 40% to 60% in 2026 and 60% to 80% in 2028. Dive Insight Boston Scientific forecast an 8% to 10% organic sales compound annual growth rate ...
- Source: drugdu
- 239
- September 25, 2023
Photobiomodulation in sleep has more therapeutic effects for Alzheimer’s disease than in wakefulness

It is well known that sleep is the best medication. However, it is still unknown why the brain recovers better in sleep and whether these processes can be controlled. Recent discoveries have shown that the lymphatic system of the brain is activated during sleep, which contributes to the removal of metabolites, toxins and unnecessary molecules from its tissues. Sleep disturbance contributes to the deposition of metabolites in the central nervous system (CNS). For example, sleep is a biomarker for the development of Alzheimer’s disease. This is due to the fact that the toxic metabolite beta-amyloid is excreted from brain tissue during sleep. Sleep deprivation leads to the accumulation of toxin in the CNS, which over time can lead to the development of Alzheimer’s disease. In this pilot study, the researchers have shown that non-invasive sleep photobiomodulation technology can effectively increase lymphatic excretion of beta-amyloid from the brain tissues of mice ...
- Source: drugdu
- 210
- September 25, 2023
U-M receives CDC grant to establish new center to improve public health response to disease outbreaks

The University of Michigan is among 13 institutions that will receive funding from the Centers for Disease Control and Prevention to be part of a national network of centers focused on predicting and responding to future disease outbreaks. U-M will receive a $17.5 million grant over five years to establish the Michigan Public Health Integrated Center for Outbreak Analytics and Modeling, or MICOM. Housed within the U-M School of Public Health, MICOM is a partnership with the Michigan Department of Health and Human Services and a national collaboration among institutions’ experts, who represent a wide variety of disciplines. At U-M, researchers from the College of Engineering, School of Information, Medical School and College of Literature, Science, and the Arts will also lend their expertise to the effort. Marisa Eisenberg, director of MICOM and associate professor of epidemiology and complex systems, “This center is a remarkable opportunity to build on the ...
- Source: drugdu
- 134
- September 22, 2023

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