Young children with common ear, nose, and throat (ENT) issues may be at subsequent risk of autism or high levels of demonstrable autism traits, suggests research published online in BMJ Open. Early identification and treatment of ENT conditions may improve these children’s quality of life and potentially help shed light on some of the origins of autism, say the researchers. The causes of autism are likely to involve an interplay of genetic, environmental, and biological factors, and the origins of each autistic trait may also differ, note the researchers. Previous research suggests that ENT conditions, such as ear infections, “glue ear,” and sleep-disordered breathing may have a role in the development of autism. But most of this evidence is based on health records, which may have biased these findings, because parents of children with suspected autism may be more likely than other parents to seek medical help for their offspring, ...
Nurses exposed to 40 minutes of bright light before their night shifts feel less fatigued and make fewer errors at work, according to a study led by McGill University. The nurses also slept better after their shifts. “Healthcare workers are experiencing high levels of fatigue due to staffing shortages, difficult schedules, and heavy workloads. Further, the cost of medical errors has been estimated at tens of billions of dollars per year in North America,” says Jay Olson, the senior author of the recent study in Sleep Health, who completed his PhD at McGill University and is now a Postdoctoral Fellow at the University of Toronto. “Our study shows that feasible changes, such as getting light exposure before the night shift, may help reduce fatigue and its effects on performance at work, something which could benefit both the nurses and their patients.” Light exposure leads to a significant reduction ...
What you eat might influence when you go to sleep, according to a new study of elite female college athletes. Researchers will present their work this week at the American Physiology Summit, the flagship annual meeting of the American Physiological Society (APS), in Long Beach, California. The study revealed that athletes who consumed more carbohydrates and vitamins B12 and C tended to go to sleep earlier and wake earlier than those who consumed less of these nutrients. According to the researchers, these nutrients might increase synthesis of vital hormones that regulate sleep, including serotonin and melatonin. “For athletes, success is measured not only by readiness to perform but also resiliency on and off the field,” said the study’s first author Lauren Rentz, a doctoral student at West Virginia University. “We know that sleep helps the body heal from daily physical and mental stress and influences future physical and mental ...
The combination of an experimental mRNA vaccine with an immunotherapy reduced the likelihood of melanoma recurring or causing death by 44% when compared to immunotherapy alone, a new clinical trial shows. Led by researchers at NYU Langone Health and its Perlmutter Cancer Center, the randomized phase 2b trial involved men and women who had surgery to remove melanoma from lymph nodes or other organs and were at high risk of the disease returning in sites distant from the original cancer. Among 107 study subjects who were injected with both the experimental vaccine, called mRNA-4157/V940, and the immunotherapy pembrolizumab, the cancer returned in 24 subjects (22.4%) within two years of follow-up, compared with 20 out of 50 (40%) who received only pembrolizumab. “Our phase 2b study shows that a neoantigen mRNA vaccine, when used in combination with pembrolizumab, resulted in prolonged time without recurrence or death compared with pembrolizumab alone,” said study senior investigator ...
By Brenda Goodman, CNN Updated 2:49 PM EDT, Tue April 11, 2023 The US Environmental Protection Agency on Tuesday proposed a set of new restrictions on facilities that use the cancer-causing chemical ethylene oxide, a colorless, odorless gas that is used to sterilize medical devices and spices. The agency said the new rules, which have not been finalized, would help to reduce ethylene oxide gas that these facilities release by 80%, bringing emissions below a Clean Air Act standard for elevated cancer risk. Communities exposed to ethylene oxide gas have been pushing the EPA to put tighter controls on plants that use ethylene oxide gas. In 2018, an EPA report found that dozens of communities across the nation faced elevated cancer risks because of trace of amounts of ethylene oxide released into air as part of the sterilization process. The EPA issued the report on the new risks without issuing a news release, as ...
Dive Brief: The Food and Drug Administration told Merck KGaA not to give an experimental drug for multiple sclerosis to new patients and to pause treatment for study participants who have been on it for less than 70 days amid concerns about possible liver damage. Regulators acted after laboratory tests suggested the livers of two patients might have been adversely affected by the drug, known as evobrutinib. However, neither patient exhibited symptoms and their liver enzyme levels returned to normal after they stopped taking the medicine, Merck KGaA said Wednesday. The German drugmaker had already fully enrolled a Phase 3 study known as Evolution, and that program will continue as planned because all the patients have already had received the medication for at least 70 days. Results are still expected in the fourth quarter. Dive Insight: Evobrutinib is part of a class of drugs known as BTK ...
On Thursday, the US Food and Drug Administration announced its final decision to withdraw its approval of Makena, a drug approved more than a decade ago to reduce the risk of preterm birth that had been the only medication approved for the condition. The FDA says that the drug is not effective and that the benefits of taking it do not outweigh the risks. “It is tragic that the scientific research and medical communities have not yet found a treatment shown to be effective in preventing preterm birth and improving neonatal outcomes – particularly in light of the fact that this serious condition has a disparate impact on communities of color, especially Black women,” FDA Commissioner Dr. Robert Califf said in a statement. “Fundamentally, however, the touchstone of FDA drug approval is a favorable benefit-risk assessment; without that favorable assessment, the drug should not have the status of ...
Dr. Priyom Bose, Ph.D. By Dr. Priyom Bose, Ph.D.Apr 5 2023 Reviewed by Danielle Ellis, B.Sc. To combat the double burden of non-communicable diseases and climate change, adopting sustainable and healthy diets and transitioning to sustainable food systems is essential. To support food security and sustainable development, the Mediterranean diet (MD) has been widely recognized as a healthy nutrition and biodiversity resource. A recent Advances in Nutrition study explored biodiversity and analyzed food-plant diversity differences between the Western diet and the MD. Background The global population is expected to rise to 10.9 billion by the end of the century. The Food and Agriculture Organization (FAO) estimates that food production must increase by almost 50% to meet consumers’ demands. Rapid population growth is often considered a threat to sustainable development, as it stresses natural resources. The existing agro-food system has also been cited as a key driver of climate change and environmental ...
One in six people worldwide are affected by infertility, according to a report that lays bare the scale of the problem. About 17.5% of the global adult population – roughly one in six – will experience infertility at some point in their lifetime, the 98-page report published by the World Health Organization (WHO) says. The figures are its first estimates of infertility prevalence in more than a decade. Dr Tedros Adhanom Ghebreyesus, the WHO director general, said the report underlined the magnitude of infertility as a public health issue globally, and showed there was an urgent need to expand access to prevention, diagnosis and treatments. “The report reveals an important truth – infertility does not discriminate,” said Tedros. “The sheer proportion of people affected shows the need to widen access to fertility care and ensure this issue is no longer sidelined in health research and policy, so that safe, effective and affordable ...
Bad dreams are common and rarely are a sign of significant health concerns. However, several new studies have found potentially troubling associations between frequent or persistent nightmares and future cognition. These findings, along with recent insights into a potential intervention, have resulted in the top trending clinical topic this week. Previous investigations have found a link between sleep problems in adulthood, including nightmares, and the onset of neurodegenerative diseases. A recent analysis determined a possible association between distressing dreams during childhood and cognitive health concerns (see Infographic). A prospective, longitudinal analysis used data that included all people born in Britain during a single week in 1958. At age 7 years (in 1965) and 11 years (in 1969), mothers were asked to report whether their child experienced “bad dreams or night terrors” in the past 3 months. Among 6991 children (51% girls), 78.2% never had bad dreams, 17.9% had transient bad ...
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