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Arterial stiffness may be a novel risk factor for childhood and adolescent metabolic disease

Arterial stiffness may be a novel risk factor for metabolic syndrome in teens, a paper published in the American Journal of Physiology-Heart and Circulatory Physiology concludes. The study was conducted in collaboration between the University of Bristol in the UK, the University of Exeter in the UK, and the University of Eastern Finland. The presence of any three of high blood pressure, high trunk fat mass, high fasting glucose, high fasting triglyceride and low fasting high-density lipoprotein cholesterol describes metabolic syndrome. Arterial stiffness in adolescents measured with carotid-femoral pulse wave velocity may potentially cause metabolic syndrome in young adulthood via an increase in fasting insulin resistance and low-density lipoprotein cholesterol. Image Credit: Andrew Agbaje. The World Health Organization describes metabolic syndrome as the constellation of three or more of the following: abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. The prevalence of metabolic syndrome in US middle-aged adults is 30%, ...
- Source: drugdu
- 109
- April 27, 2023
Study shows no significant cognitive benefit of adhering to Mediterranean diets regardless of calorie intake

In a recent study published in Preventive Medicine Reports Journal, researchers performed a randomized clinical trial (RCT) to investigate whether adhering to the Mediterranean diet (MedDiet) with or without limiting calorie intake could improve cognition. Background Obesity, lifestyle choices including diet and exercise, and cardiometabolic comorbidities elevate the risk of cognitive decline. To date, there are no efficient pharmaceutical therapeutics available to prevent, retard, or manage cognitive deficits. However, studies have shown that MedDiet and weight loss benefit cognition, and combining the two may enhance cognitive function. However, RCTs have shown inconsistent results, with either a favorable or negligible impact of nutrition on cognition, warranting further research. About the study In the present three-arm RCT, researchers evaluated the potential cognitive benefit of adhering to MedDiet with or without limiting calorie intake. The Building Research in Diet and Cognition study was conducted between January 2017 and ...
- Source: drugdu
- 134
- April 27, 2023
New tool charts differentiation landscape of acute myeloid leukemia

by Center for Genomic Regulation Researchers have developed a new method to distinguish between cancerous and healthy stem cells and progenitor cells from samples of patients with acute myeloid leukemia (AML), a disease driven by malignant blood stem cells that have historically been difficult to identify. The findings, published today in the journal Cell Stem Cell, pave the way for the development of new techniques to predict whether patients will respond to chemotherapy. AML is a type of cancer characterized by the rapid growth and accumulation of abnormal white blood cells. It is thought to develop when blood progenitor cells, which normally turn into all other types of blood cells, fail to mature properly and become abnormal. In this process, blood stem cells carry a special importance because they give rise to progenitor cells and are thought to be the cell type in which leukemic mutations occur. Leukemic stem cells are thought ...
- Source: drugdu
- 124
- April 26, 2023
NovaBay to introduce new cream for psoriasis

Known as DERMAdoctor Comfort + Joy Psoriasis Therapeutic Moisturizing Cream with 3% salicylic acid, the product will be introduced on the QVC network. The new cream will be used to treat and provide relief for psoriasis symptoms, including redness, irritation, itching, flaking, and scaling, and also helps to restore moisture in skin. It has been developed to relieve and prevent the recurrence of psoriasis symptoms. The new Psoriasis Therapeutic Moisturizing Cream with 3% Salicylic Acid delivers a mix of ceramides, hyaluronic acid, essential fatty acids, aloe vera, shea butter, and botanicals to calm and moisturise dry, uncomfortable skin. The company noted that the steroid-free and fragrance-free formulation of the cream is even suitable for the most sensitive skin from head to toe. NovaBay Pharmaceuticals chief product officer Dr Audrey Kunin said: “Psoriasis afflicts about 125 million people worldwide and nearly eight million in the ...
- Source: drugdu
- 119
- April 26, 2023
Embracing Personalization in Biopharma Patient Support Programs

Can we really call ourselves patient-centric if we don’t embrace personalization? In a world where consumers can order a customized latte, stream a personalized playlist, and get tailored fashion recommendations with a few clicks, it’s no wonder that patients are increasingly demanding that same level of personalization from the pharmaceutical companies that provide them with life-changing medications. In comparison to other industries, such as retail and banking, pharma is still considered to be somewhat behind in delivering on this patient expectation. This has been largely due to a lack of data integration across the ecosystem, disparate access to digital technologies, and regulatory constraints. However, the industry is well poised to overcome these challenges because of two major forces. The first is the democratization of information, providing access to data to power personalization; 63% of patients would be willing to share their data with pharma companies for greater personalization.1 The ...
- Source: drugdu
- 134
- April 26, 2023
After delay, Bluebird submits sickle cell gene therapy for FDA approval

Bluebird bio said Monday it has submitted its lovo-cel gene therapy for sickle cell disease for Food and Drug Administration approval, ending a brief delay as it awaited feedback from the agency on manufacturing. The Massachusetts-based drugmaker missed its goal to submit an application by the end of March, allowing Vertex Pharmaceuticals and CRISPR Therapeutics to jump ahead with an approval application for a competing therapy. The agency now has until late June to decide whether to accept Bluebird’s application. The company is seeking a “priority,” or expedited, review, which if granted would shorten the review from 10 months to six. Bluebird is planning for an expedited review and, should an approval be granted, an early 2024 commercial launch. Lovo-cel is viewed by analysts as Bluebird’s best chance for business success because many more people in the U.S. have sickle cell disease than the rarer conditions ...
- Source: drugdu
- 169
- April 26, 2023
New machine-learning method predicts body clock timing to improve sleep and health decisions

A new machine-learning method could help us gauge the time of our internal body clock, helping us all make better health decisions, including when and how long to sleep. The research, which has been conducted by the University of Surrey and the University of Groningen, used a machine learning program to analyze metabolites in blood to predict the time of our internal circadian timing system. The study is published in the journal Proceedings of the National Academy of Sciences. To date the standard method to determine the timing of the circadian system is to measure the timing of our natural melatonin rhythm, specifically when we start producing melatonin, known as dim light melatonin onset (DLMO). Professor Debra Skene, co-author of the study from the University of Surrey, said, “After taking two blood samples from our participants, our method was able to predict the DLMO of individuals with an accuracy comparable ...
- Source: drugdu
- 125
- April 26, 2023
Common ear, nose, and throat issues in preschoolers may be linked to later autism risk

Young children with common ear, nose, and throat (ENT) issues may be at subsequent risk of autism or high levels of demonstrable autism traits, suggests research published online in BMJ Open. Early identification and treatment of ENT conditions may improve these children’s quality of life and potentially help shed light on some of the origins of autism, say the researchers. The causes of autism are likely to involve an interplay of genetic, environmental, and biological factors, and the origins of each autistic trait may also differ, note the researchers. Previous research suggests that ENT conditions, such as ear infections, “glue ear,” and sleep-disordered breathing may have a role in the development of autism. But most of this evidence is based on health records, which may have biased these findings, because parents of children with suspected autism may be more likely than other parents to seek medical help for their offspring, ...
- Source: drugdu
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- April 26, 2023
Seasonal Variation in Thyroid Hormone TSH May Lead to Overprescribing

By Miriam E. Tucker Seasonal variation in one of the hormones used to monitor thyroid function could in turn lead to false diagnoses of subclinical hypothyroidism and unnecessary prescriptions of levothyroxine, says Yale clinical chemist Joe M. El-Khoury, PhD. He says a Japanese study in more than 7000 healthy individuals showed that thyrotropin-stimulating hormone (TSH) varies widely throughout the seasons, peaking in the northern hemisphere’s winter months (January to February) with its low in the summer months (June to August); that paper was published last year in the Journal of the Endocrine Society. But free thyroxine (FT4) levels in the Japanese population remained relatively stable, he writes in a letter recently published in Clinical Chemistry. “If you end up with a mildly elevated TSH result and a normal FT4, try getting retested 2-3 months later to make sure this is not a seasonal artifact or transient increase before prescribing/taking levothyroxine unnecessarily,” advises El-Khoury, who is director of Yale University’s Clinical Chemistry Laboratory, ...
- Source: drugdu
- 131
- April 26, 2023
New study of age-related macular degeneration finds causal genes, dispels previous assumptions

by Justin Jackson , Medical Xpress A study led by the research center of Genentech in South San Francisco, published in Cell Genomics, has looked for drug targets that could address age-related macular degeneration (AMD), a condition at the center of vision problems for 200 million people worldwide. AMD can result in blindness. In the paper “A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration,” the researchers describe the steps they took to identify genes targetable by treatment with a molecular atlas of AMD pathology development stages. The study resulted in the identification of 23 significant genome-wide loci that are differentially methylated in AMD. Over 1,000 differentially expressed genes were found across disease stages and distinct Müller cell states in AMD-affected eyes. The research highlights causal gene upregulations and underlying genetic risks for AMD. Researchers generated bulk-tissue and single-cell transcriptomics and epigenomics data from 85 unique human ...
- Source: drugdu
- 125
- April 26, 2023

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