Bayer AG and its subsidiary, BlueRock Therapeutics LP, have announced positive topline results from an early-stage study of an experimental Parkinson’s disease stem cell therapy. In the phase 1 study of bemdaneprocel, the treatment was shown to be well-tolerated in all 12 patients involved in the study, and transplanted cells grew as intended in the patients’ brains at one-year post-transplant. The companies said that, based on these positive results, planning is already underway for a phase 2 study that is expected to begin enrolling patients in the first half of 2024. There is no cure for Parkinson’s disease, a progressive and chronic neurological disorder that affects an estimated ten million people worldwide. The disease is caused by nerve cell damage in the brain, which leads to decreased levels of dopamine. The loss of these dopaminergic neurons results in a progressive decline of motor function and symptoms such as tremors, muscle ...
Researchers warn that a colorless chemical known as trichloroethylene (TCE) — which has been used to dry-clean clothes, degrease metals and decaffeinate coffee — may be linked to the dramatic increase in Parkinson’s disease (PD) cases. They recently published a series of seven cases in the Journal of Parkinson’s disease that illustrate TCE’s harmful health effects and the potential PD association. “TCE is associated with a 500% increased risk of Parkinson’s disease,” lead author Dr. Ray Dorsey, professor of neurology at the University of Rochester in New York and author of “Ending Parkinson’s Disease,” told Fox News Digital. The chemical reproduces the features of the neurological disease in laboratory animals. It impairs the function of the energy-producing parts of cells called mitochondria, which are known to be damaged in Parkinson’s disease, Dorsey added. Widespread applications of TCE TCE was first synthesized in the lab in ...
The US Food and Drug Administration (FDA) has approved a new drug to treat Parkinson’s disease, providing hope for millions of patients who suffer from this debilitating condition. The drug, called Levodopa/Carbidopa Enteral Suspension (LCES), is the first new treatment for Parkinson’s disease to be approved by the FDA in over a decade. Parkinson’s disease is a progressive neurodegenerative disorder that affects movement and is caused by the degeneration of dopamine-producing neurons in the brain. The symptoms of Parkinson’s disease include tremors, stiffness, and difficulty with coordination and movement. LCES is a combination of two drugs, Levodopa and Carbidopa, that work together to increase the levels of dopamine in the brain. This can help to improve the symptoms of Parkinson’s disease and provide relief for patients. The approval of LCES is a significant development in the treatment of Parkinson’s disease, which has been largely treated with the ...
Capturing a patient’s experience outside the doctor’s office has been an ongoing struggle when it comes to treating Parkinson’s disease. But now a new smartphone app can now detect the severity of symptoms in patients with Parkinson’s disease remotely, according to a recent study published by JAMA.
Until very recently, Parkinson's had been thought a disease that starts in the brain, destroying motion centers and resulting in the tremors and loss of movement. New research published this week in the journal Brain, shows the most common Parkinson's gene mutation may change how immune cells react to generic infections like colds, which in turn trigger the inflammatory reaction in the brain that causes Parkinson's. The research offers a new understanding of Parkinson's disease.
Company to move forward with novel therapies for migraine and Parkinson’s disease
HAIFA, Israel and MIAMI, Florida – INSIGHTEC®, a commercial-stage medical technology company revolutionizing surgery with incisionless MRI-guided focused ultrasound (MRgFUS) announced today the closing of a $150 million Series E private equity investment round. Koch Disruptive Technologies (KDT), a subsidiary of Koch Industries, focused on finding and funding innovative and emerging companies, led the round with a $100 million investment.
The team has unveiled a neural stimulator that is less than a cubic millimeter in size that can be placed directly where desired and that is powered using an external induction-based system.
Carmot Therapeutics, (Berkeley, CA) announced that it has entered into a multi-year drug discovery collaboration and licensing agreement with Amgen (Thousand Oaks, CA). As part of the agreement, Carmot will apply its proprietary lead-identification technology, Chemotype Evolution, to discover and advance novel drug leads intended for the treatment of Parkinson’s disease and other selected disease areas.
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