Kangfang Biopharma’s new dual-antibody drug Ivoside is planned to be included in the breakthrough therapy designation for the treatment of triple-negative breast cancer
October 29, 2025
Source: drugdu
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Shanghai Securities News China SecuritiesNet News (Reporter Zhang Xue) On October 24, Kangfang Bio 's Class 1 new drug PD-1/VEGF dual antibody Ivoside (AK112) injection was planned to be included in the breakthrough therapy variety. The indication is Ivosidemab combined with chemotherapy as the first-line treatment for locally advanced unresectable or metastatic triple-negative breast cancer.
Ivoside is a new dual-antibody drug with a synergistic anti-tumor mechanism of "tumor immunity + anti-angiogenesis." It simultaneously targets two important targets, PD-1 and VEGF, and synergistically exerts both tumor immunity and tumor anti-angiogenesis mechanisms, potentially providing a more effective treatment option for these patients.
In February 2025, Kangfang Bio announced that the first patient had been enrolled in the multicenter, randomized, double-blind Phase 3 clinical study (HARMONi-BC1/AK112-308) of Ivoside combination therapy as the first-line treatment for unresectable locally advanced or metastatic triple-negative breast cancer (TNBC).
Source：https://finance.eastmoney.com/a/202510243543410637.html
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