Scientists use Infrared Sensor as Means for Drug Discovery
July 28, 2018
Source: ScienceDaily
657
Biophysicists at Ruhr-Universität Bochum (RUB) have used an infrared sensor to discover which active agents influence the structure of proteins rapidly and easily and calculate the amount of time the change persists.
Prof Dr. Klaus Gerwert and Dr. Jörn Güldenhaupt thus executed time-resolved measurements of the changes to the structure of protein scaffolds, caused by the active agents. Their methods look promising for the future development of drugs with minimum side effects.
A report on their research was published by the team, in the journal, Angewandte Chemie on May 17, 2018.
This novel technique offers information on structural changes in the protein in a matter of minutes, also displaying the type of structural change. The sensor works with the help of a crystal to which the protein is bound and infrared light can permeate through the crystal. Infrared spectra are read via the crystal, and the surface is bathed with solutions that may or may not contain active agents. The sensor detects variations to the spectral area of the protein. If any changes are noticed, it is evident that the active agent has distorted the shape of the protein.
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