Drugdu.com expert's response:

The efficacy of Semaglutide Injection by East China Pharmaceutical is primarily reflected in the following aspects:

Blood Glucose Control: Semaglutide Injection is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. It stimulates insulin secretion in a glucose concentration-dependent manner, inhibits glucagon release, and delays gastric emptying, thereby effectively lowering blood glucose levels. It has significant effects on both fasting and postprandial blood glucose, helping patients with type 2 diabetes mellitus (T2DM) better control blood glucose fluctuations and reduce the damage caused by hyperglycemia. This medication is suitable for T2DM patients who have inadequate blood glucose control despite dietary and exercise modifications. It can significantly improve blood glucose indicators when used alone or in combination with other drugs.

Weight Management: Semaglutide can suppress appetite by acting on the central nervous system to modulate neural signals related to food intake, thereby reducing food consumption. Additionally, it delays gastric emptying and increases satiety. Long-term use can lead to a weight reduction of approximately 10%-15% in patients, making it particularly suitable for diabetic patients with obesity.

Cardiovascular Protection: Semaglutide has the effect of reducing the risk of cardiovascular diseases. Its mechanisms include improving vascular endothelial function, reducing the release of inflammatory factors, and alleviating dyslipidemia. Clinical studies have shown that Semaglutide can reduce the risk of major adverse cardiovascular events (such as myocardial infarction and stroke) by approximately 26%, helping to inhibit the progression of atherosclerosis.

Renal Protection: Semaglutide can reduce urinary protein excretion and delay the decline in glomerular filtration rate, thereby providing renal protection for patients with diabetic nephropathy. This may be related to improvements in hemodynamics and the inhibition of renal fibrosis pathways.

Lipid Regulation: Semaglutide can lower triglyceride levels and moderately reduce low-density lipoprotein cholesterol (LDL-C) levels, optimizing the lipid profile and reducing the damage caused by dyslipidemia to the vascular wall.