Drugdu.com expert's response:

Imported drugs are not absolutely more effective than domestic drugs. The difference in their efficacy is influenced by multiple factors, including drug type, research and development (R&D) technology, formulation processes, and individual patient variations. A comprehensive assessment based on specific circumstances is necessary. Below is a detailed analysis:

I. The Difference in Drug Efficacy is Not Absolute

Common Diseases: For common illnesses such as colds and coughs, there is little difference in efficacy between domestic and imported drugs. For example, domestic paracetamol has been widely recognized for its antipyretic and analgesic effects and is more cost-effective.

Chronic Diseases: In the treatment of chronic diseases requiring long-term medication, such as hypertension and diabetes, imported drugs may offer better patient compliance due to their precise formulations and superior side effect management. However, domestic drugs that have passed consistency evaluations are equally reliable in terms of efficacy and safety.

Complex Diseases: In the treatment of complex diseases like cancer and autoimmune disorders, imported drugs (especially novel targeted therapies and immunotherapies) often dominate due to their substantial R&D investments, stringent quality control, and potentially more stable efficacy.

II. Key Factors Influencing Drug Efficacy

R&D Background and Technological Strength: Imported drugs typically have a longer R&D history and a more mature technological framework, undergoing multiple rounds of clinical trials and technical optimizations, adhering to stricter R&D processes and quality standards. Although domestic drugs have made significant progress in recent years, there is still a gap in overall technological accumulation.

Formulation Processes and Bioavailability: Imported drugs often employ more advanced formulation technologies, such as sustained-release and controlled-release formulations, which can better control drug release rates and times, thereby enhancing drug bioavailability. While domestic drugs have improved in formulation processes, they still need to catch up in some areas.

Drug Purity and Impurity Control: Imported drugs have higher purity requirements and stricter impurity control during the R&D phase, which may contribute to more stable efficacy. Although domestic drugs have met international standards in purity control, there are still slight differences in purity compared to imported drugs for some medications.

Individual Patient Variations: Different patients may respond differently to the same drug. For example, some patients may respond well to domestic drugs, while others may be more suited to imported drugs. Therefore, drug efficacy must be evaluated comprehensively based on the specific circumstances of each patient.

III. Advantages and Limitations of Domestic Drugs

Price Advantage: Domestic drugs are generally more affordable, which can alleviate the economic burden on patients, especially in cases of long-term medication.

Adaptability to Local Needs: Domestic drugs are often developed with a focus on the genetic characteristics, lifestyle habits, and other specific needs of the Chinese population, making them better suited to meet the treatment needs of domestic patients. For example, some domestic drugs have been adjusted in dosage and formulation to better suit Chinese patients.

Quality Improvement: With the implementation of the consistency evaluation system, the quality of domestic drugs has significantly improved, with some drugs approaching or reaching the efficacy and safety levels of imported drugs. However, in the field of complex diseases, the innovation capabilities and technological accumulation of domestic drugs still need to be strengthened.

IV. Advantages and Limitations of Imported Drugs

Efficacy Stability: Imported drugs typically involve substantial R&D investments and stricter quality control, especially in the treatment of complex diseases, where their efficacy stability is often superior.

Innovativeness and Diversity: Imported drugs often offer greater variety and innovation in terms of types and efficacy. They may contain unique chemical formulations, novel drug formulations, or targeted therapeutic approaches, providing patients with more treatment options.

High Cost: Imported drugs are generally more expensive due to significant R&D investments, high marketing expenses, and additional costs for transportation and tariffs. For patients with limited financial means, long-term use of imported drugs may exacerbate economic burdens.

Adaptability Limitations: Due to differences in race, physique, and drug sensitivity, some imported drugs that are not marketed in China may not be fully suitable for the Chinese population.

In conclusion, the choice between domestic and imported drugs should be based on a comprehensive evaluation of drug efficacy, safety, cost, and individual patient needs. Both types of drugs have their strengths and limitations, and a patient-centered approach is essential to ensure optimal treatment outcomes.