Clover Biopharmaceuticals’ Phase I clinical data for its respiratory combination vaccine and RSV vaccine are positive.
October 15, 2025
Source: drugdu
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On October 14, Clover Biopharmaceuticals (02197) announced positive data from Phase I clinical trials of its respiratory combination vaccine (RSV-hMPV-PIV3) and repeat RSV vaccine in the elderly population. Both Phase I clinical trials in Australia and the United States demonstrated favorable safety and immune responses.
Specifically, in the Australian trial, the mean doubling rates of RSV neutralizing antibodies induced by SCB-1022 (RSV+hMPV) and SCB-1033 (RSV+hMPV+PIV3) were approximately 6-8 times, and the mean doubling rates of hMPV-A and hMPV-B neutralizing antibodies were 6-7 times and 8-9 times, respectively.
In repeat vaccination trials in the United States, heterologous repeat vaccinations of SCB-1019 (an RSV vaccine candidate) resulted in a mean RSV neutralizing antibody doubling rate of approximately 3.0-3.3 times. In contrast, homologous repeat vaccinations of AREXVY only boosted antibody levels to approximately 60-65% of the peak levels induced after the first dose. The company plans to advance SCB-1022 and SCB-1033 into Phase II clinical trials in the first half of 2026.
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