By Tristan Manalac

Pictured: A Biogen building/courtesy of PictureDesignSwiss/shutterstock

Biogen announced Monday that three of its directors—Alexander Denner, William Jones and Richard Mulligan—will not stand for re-election at the company’s annual stockholder meeting Wednesday. Instead, Susan Langer will be up for election to Biogen’s board of directors.
This latest shake-up comes after board chair Stelios Papadopoulos announced he was stepping down from his post after the annual meeting. Papadopoulos will be succeeded by Caroline Dorsa, a long-standing member of Biogen’s board who had previously served for more than two decades at Merck.
Meanwhile, Langer is currently serving as president of Souffle Therapeutics, a privately held start-up that has most recently scored $50 million in investments, according to PitchBook. Before that, Langer was also the founding president of Kojin Therapeutics and the founding chief business officer of Paratus Sciences. She also previously worked at Biogen in posts of increasing responsibility.
Endpoints News reported that Langer is Denner’s “longstanding romantic partner,” according to sources familiar with the situation. STAT News reported that Langer is the mother of Denner’s child, born in November, according to court records.
“The full board nominated all candidates for election, including Ms. Langer. Ms. Langer is a highly qualified candidate given her experience in biotech. She will bring fresh perspective to the board. As a former Biogen colleague, she also knows the company and the biotech ecosystem very well,” the company said in an emailed statement to BioSpace.
To give Biogen stockholders enough time to review these changes, the board will hold and adjourn the annual meeting on June 14 and reconvene on June 26.
These changes come amid an “important time for Biogen,” CEO Christopher Viehbacher said in a statement. “We are working to put the company back on a sustainable growth path to deliver enhanced value for our patients, employees and shareholders,” he said.
Viehbacher is relatively new to the company. Following stints at Sanofi and GSK, Viehbacher was appointed as Biogen’s CEO in November 2022.
Busy Year So Far
Biogen’s new board will navigate the company through a dynamic year. Biogen opened 2023 with accelerated approval from the FDA for its Alzheimer’s antibody Leqembi. On Friday, the FDA’s Peripheral and Central Nervous System Drugs Advisory Committee unanimously backed Leqembi’s full approval.
The FDA will release its verdict on or before July 6.
Beyond Alzheimer’s, Biogen won an advisory committee vote for its amyotrophic lateral sclerosis candidate, tofersen, in March 2023. Voting 9–0, the panel of external experts agreed that using a neurofilament light chain biomarker could be a reasonable predictor of tofersen’s clinical benefit.
The advisory committee did not recommend traditional approval. The FDA was set to release its decision on tofersen by May 29 but pushed this back to June 22.
Amid these regulatory developments, Biogen pushed through with its strategic realignment initiative and trimmed its headcount in April 2023 and its pipeline in May 2023.

Reference: https://www.biospace.com/