Iza-bren met its primary endpoint in interim analysis of a phase III clinical trial for recurrent or metastatic esophageal squamous cell carcinoma.
November 18, 2025
Source: drugdu
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Baili Tianheng(688506) announced on the morning of November 18th that its independently developed, world's first, novel, and only EGFR×HER3 bispecific antibody ADC (iza-bren) to enter Phase III clinical trials for esophageal squamous cell carcinoma has met both primary endpoints of progression-free survival (PFS) and overall survival (OS) in the pre-specified interim analysis, as determined by the independent data monitoring committee. The indication is recurrent or metastatic esophageal squamous cell carcinoma that has failed prior treatment with PD-1/PD-L1 monoclonal antibodies combined with platinum-based chemotherapy. This is the world's first Phase III clinical study of an ADC drug to achieve double positive results for PFS/OS in the treatment of esophageal cancer.
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