PharmaFocus Today – Page 87 – media

Rare, Recurrent, and Still a Challenge

Despite the rising incidence of rheumatoid arthritis (RA), extra-articular manifestations have become rare in the era of modern treat-to-target therapy. However, they still present clinical challenges — particularly in the case of rheumatoid nodules. In addition to the need to rule out serious differential diagnoses and address potential complications, especially those involving the lungs, these recurrent inflammatory granulomas can affect daily life not only cosmetically but also functionally. Christopher Edwards, MD, professor of rheumatology at University Hospital Southampton in Southampton, England, discussed the clinical relevance and management of rheumatoid nodules during the 2025 Annual Meeting of the European Alliance of Associations for Rheumatology. When Edwards began his career in rheumatology, the presence of rheumatoid nodules was considered a key diagnostic criterion for RA. If not found on the hands, clinicians often examined the elbows and Achilles tendons, which are also common sites. Histologically, rheumatoid nodules are granulomatous inflammatory lesions that ...
- Source: drugdu
- 144
- July 4, 2025
FDA Vaccine Official Restricted COVID Vaccine Approvals Against the Advice of Agency Staff

A top official at the Food and Drug Administration recently overruled government scientists on the availability of two COVID-19 vaccinesWASHINGTON (AP) — The government’s top vaccine official working under Health Secretary Robert F. Kennedy Jr. recently restricted the approval of two COVID-19 vaccines, disregarding recommendations from government scientists, according to federal documents released Wednesday. The new memos from the Food and Drug Administration show how the agency’s vaccine chief, Dr. Vinay Prasad, personally intervened to place restrictions on COVID shots from vaccine makers Novavax and Moderna. Both vaccines were approved by the FDA in May after months of analysis by rank-and-file FDA reviewers. But internal correspondence show Prasad disagreed with staffers who planned to approve the shots for everyone 12 and older, similar to previous COVID vaccines. The scientists had concluded the benefit from the vaccines and the risk of COVID-19 outweighed the risk of possible side effects, which are ...
- Source: drugdu
- 129
- July 4, 2025
The marine economy is facing significant policy benefits, and the industrial chain is expected to continue to benefit; Two departments propose 16 measures to support the high-quality development of innovative drugs – “Investment Early Participation”

（1） Important Market News 1. The three major stock indexes in the United States closed with mixed gains and losses, with the Nasdaq falling 0.82%, the Dow Jones Industrial Average rising 0.91%, and the S&P 500 index falling 0.11%; Tesla fell over 5%, Netflix fell over 3%, Nvidia fell over 2%, Microsoft fell over 1%, and Apple rose over 1%. Chinese concept stocks fluctuated, with the Nasdaq China Golden Dragon Index up 0.2%, Huya Live up nearly 13%, NIO and Xiaopeng Motors up over 2%, Tiger Securities down over 2%, and Futu Holdings down over 1%. 2. According to CCTV News, on July 1st local time, when asked whether the uncertainty caused by the current tariff system of the US government had led to the Fed delaying interest rate cuts, Fed Powell gave a positive answer, adding that due to the impact of tariffs, almost all forecasts for US ...
- Source: drugdu
- 139
- July 3, 2025
Earwax Secretions May Help Detect Parkinson’s Disease

Odors from earwax may help distinguish individuals with Parkinson’s disease (PD) from those without the condition, a new study suggests. Researchers found that four volatile organic compounds (VOCs) in ear canal secretions significantly differed between participants with and without PD. The compounds — ethylbenzene, 4-ethyltoluene, pentanal, and 2-pentadecyl-1,3-dioxolane — may represent potential biomarkers. An artificial intelligence olfactory (AIO)-based screening model used in the study identified those with PD with 94% accuracy. “The accuracy of the model really surprised us,” study investigator Hao Dong, Research Center for Frontier Fundamental Studies, Zhejiang Lab, Hangzhou, China, MD, told Medscape Medical News. However, the study was a “small-scale, single-center experiment,” he noted in a press release. “The next step is to conduct further research at different stages of the disease, in multiple research centers, and among multiple ethnic groups in order to determine whether this method has greater practical application value,” Dong said. The ...
- Source: drugdu
- 167
- July 3, 2025
IBS Rates Nearly Doubled During the Pandemic

By Dennis Thompson HealthDay ReporterMONDAY, July 1, 2025 (HealthDay News) — The COVID-19 pandemic took a toll on Americans’ guts, researchers report. Gut disorders like irritable bowel syndrome (IBS) increased significantly during the COVID-19 pandemic, a new study says. Rates of IBS nearly doubled among U.S. adults, rising from around 6% in May 2020 to about 11% in May 2022, results show. Other gut health problems like constipation also increased, researchers report in the journal Neurogastroenterology & Motility. “Rates of digestive issues such as irritable bowel syndrome and chronic idiopathic constipation rose significantly,” lead researcher Dr. Christopher Almario, a gastroenterologist at Cedars-Sinai Medical Center in Los Angeles, said in a news release. “These findings underscore the significant toll the pandemic has taken on digestive health,” Almario added. Conditions like IBS and chronic constipation are driven by complex interactions between the gut and the nervous system, researchers said in background notes. ...
- Source: drugdu
- 123
- July 3, 2025
Kangtai Biological’s 13-valent pneumococcal vaccine obtains Türkiye’s GMP certificate and related products are expected to enter the local market

Recently, the 13-valent pneumococcal polysaccharide conjugate vaccine of Minhai Biopharmaceuticals (hereinafter referred to as Kangtai Minhai), a wholly-owned subsidiary of Kangtai Biological, obtained the GMP certification certificate issued by the Turkish Food and Drug Administration. The acquisition of this certificate indicates that the production facilities, processes, quality control and quality management systems of Minhai Biopharmaceuticals PCV13 vaccine are in compliance with Turkey’s strict pharmaceutical production quality management standards, and also indicates that the product has the necessary conditions for access to the local Turkish market. Turkey is a “crossroads” connecting the Eurasian continent, and its geographical location has significant locational advantages. The country’s economic development is growing rapidly, and its GDP ranks among the top 20 in the world. In 2024, Turkey’s total population will be about 85.66 million, and the number of newborns in 2023 will be about 950,000. In recent years, the country’s public health level and medical ...
- Source: drugdu
- 228
- July 3, 2025
Zhifei Biotech has obtained another invention patent certificate

On the evening of July 1, the company and its wholly-owned subsidiaries, Beijing Zhifei Green Bamboo Biopharmaceutical Co., Ltd. and Anhui Zhifei Longcom Biopharmaceutical Co., Ltd., recently obtained the National Intellectual Property Rights of the People’s Republic of China.An invention patent certificate issued by the Bureau, the patent name is “A primer pair and its application in BCG-CpG-DNA adjuvant quality control method”, patent number ZL202211426011.7, patent certificate number 8029182, and the application date is November 14, 2022. The company stated that the above invention patent was applied for and obtained during the research and development of the freeze-dried recombinant tuberculosis vaccine (AEC/BC02) independently developed by the company and still in the research stage, and will be used in the company’s related products under research. The acquisition of this patent certificate will not have a significant impact on the company’s recent production and operation, but it will help to further improve ...
- Source: drugdu
- 150
- July 3, 2025
Zai Lab’s Phase III clinical trial of this drug achieved positive results

On June 30, Zai Lab announced that the main data of the Phase III study of bemazumab for FGFR2b-positive first-line gastric cancer achieved positive results . Zai Lab said that the detailed results of the study will be announced at a future medical conference, but this achievement is expected to redefine the standard treatment of first-line gastric cancer and bring new hope of survival to gastric cancer patients. 01 New breakthrough The FORTITUDE-101 study is a global multicenter, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the efficacy and safety of bematuzumab combined with mFOLFOX6 chemotherapy versus placebo combined with mFOLFOX6 as first-line treatment. The study was conducted in 300 research centers in 37 countries around the world, with a total of 547 patients enrolled. The study met its primary endpoint of overall survival (OS) at a pre-specified interim analysis, with bematumab plus chemotherapy demonstrating a statistically significant and clinically ...
- Source: drugdu
- 135
- July 3, 2025
The first domestic generic version of Lifelast Eye Drops (5%) was approved for marketing

On June 30, the official website of the National Drug Evaluation Center showed that Kanghong Pharmaceutical’s lifetilast eye drops (trade name Langyueming) were exclusively launched in China as a Class 3 new drug, which will provide a new option for dry eye treatment. With the popularization of electronic devices, the acceleration of the aging process and bad eye habits, the incidence of dry eyes in China has been increasing year by year. The number of people suffering from dry eyes or dry eye symptoms in China exceeds 300 million. According to a research report by the China Economic Industry Research Institute, the domestic dry eye drug market will reach 4.79 billion yuan in 2024, with a compound growth rate of 16.17% from 2020 to 2024, providing a huge market space for the development of dry eye drugs. Inflammatory response is the driving factor of ocular surface damage in the pathological ...
- Source: drugdu
- 134
- July 3, 2025
Apple may abandon its self-developed AI models; Zuckerberg announces restructuring of Meta AI team | Global technology early participation

NO.1 Apple may abandon self-developed AI models According to foreign media sources, Apple is considering abandoning its self-developed internal model and using Anthropic or OpenAI’s artificial intelligence (AI) technology to drive the new version of Siri. Insiders revealed that Apple has contacted these two companies to discuss deploying their Large Language Model (LLM) on Apple’s own cloud infrastructure for testing. Comment: This collaboration may indicate that Apple’s self-developed progress in the AI field is not as expected and requires external forces to accelerate development. NO.2 Moderna Influenza Vaccine Phase III Clinical Trial Successfully Completed On Monday, US vaccine manufacturer Moderna announced that its experimental influenza vaccine based on mRNA had a stronger immune response than the existing vaccine in a phase III trial, which paved the way for the approval of its COVID-19/influenza combined vaccine. Comment: This achievement not only brings new hope to the influenza vaccine market, but ...
- Source: drugdu
- 206
- July 2, 2025

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