PharmaFocus Today – Page 578 – media

Molecular component of caffeine may play a role in gut health

Brigham researchers studying how and why certain cell types proliferate in the gut found that xanthine, which is found in coffee, tea and chocolate, may play a role in Th17 differentiation. Insights may help investigators better understand gut health and the development of conditions such as inflammatory bowel disease. The gut is home to a cast of microbes that influence health and disease. Some types of microorganisms are thought to contribute to the development of inflammatory conditions, such as inflammatory bowel disease (IBD), but the exact cascade of events that leads from microbes to immune cells to disease remains mysterious. A new study by investigators from Brigham and Women’s Hospital explores exactly what leads to the generation of Th17 cells—an important subtype of cells in the intestine—and uncovers some of the underappreciated molecular players and events that lead to cell differentiation in the gut. One of those players is the purine metabolite xanthine, which is found ...
- Source: drugdu
- 615
- March 15, 2023
An overview of COVID-19-associated neurological complications in children

In a recent study posted to the Research Square* preprint server, an international team of researchers review current literature to understand the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, abnormal neuroimaging manifestations, and neurological symptoms among individuals under the age of 18. Background The clinical presentation of the coronavirus disease 2019 (COVID-19) varies widely across individuals, ranging from asymptomatic or mild to severe cases involving acute respiratory distress syndrome (ARDS), pneumonia, and multi-organ complications. Emerging evidence suggests that the thrombogenic reactions and cytokine storm that develop during acute COVID-19 contribute to psychiatric and neurological complications, with a high incidence of intracerebral hemorrhage and ischemic stroke. While many studies have investigated the neurological complications associated with acute SARS-CoV-2 infections among adults, COVID-19 manifestations among children have largely been asymptomatic or mildly symptomatic and not require hospitalization. However, emerging evidence indicates that systemic symptoms such as secondary inflammatory responses, which are collectively known ...
- Source: drugdu
- 500
- March 15, 2023
Ddu College——WHO vaccine pre-certification How to conduct effective consultation?

From November 1st to 2nd, 2018, the annual World Health Organization (WHO) Prequalification (PQ) consultation will be held in Kunming, China. Unlike previous years, this year’s consultation will only take the one-on-one format, namely the World Health Organization Vaccine Pre-Certification Review Team and small meetings of various domestic vaccine manufacturers. Although the part of the centralized consultation meeting will be cancelled, which means companies and international organizations are unable to discuss and share the importance of pre-certification, but it’s believed that after several years of consultations, everyone has already cooked up the importance and significance of pre-certification. Evidence? This year’s 14 vaccine manufacturers actively participate in the one-on-one consultation is the best proof. As of November 2018, there were 4 manufacturers and vaccines that successfully passed the pre-certification of vaccines in China, namely, Chengdu institution’s Yinao, Hualan’s Liugan, Kexing’s Miejia and Beishengyan’s bOPV. At the PQ consultation meeting in Beijing ...
- Source: drugdu
- 1,909
- August 25, 2021
Special activity for the 5th Anniversary of Drugdu.com

Share Your Story with Drugdu (www.drugdu.com) Grand rewards of USD $800 in value are waiting for you! Activity period: August 12, 2021-August 31, 2021 Objects: All registered users of Drugdu Story Content: How did you make a successful trade on Drugdu? eg: experience of communication with your buyers and what did you learnt from it; how to follow up an inquiry; tactics of a successful communication; memories of how you made the deal, etc. How to operate a website/websites on Drugdu? eg: tips on how to reply an inquiry; analyses methods on potential buyers and inquiries; skills of developing more customers, etc. How is your cooperation with Drugdu? Manuscript Requirements: Original work, no limit of the style, no less than 800 words. When you submit the manuscript, please add a [The 5th Anniversary] in the subject of the mail, and your name and tel/phone number should be clarified. eg: ...
- Source: drugdu
- 541
- August 10, 2021
Remdesivir Doesn’t Reduce COVID-19 Patients’ Risk of Death Study

MONDAY, Oct. 19, 2020 (HealthDay News) — The antiviral drug remdesivir doesn’t reduce COVID-19 patients’ risk of death, a new study says. The World Health Organization-sponsored study of the drug — the only antiviral authorized for treatment of COVID-19 in the United States –included more than 11,000 people in 30 countries, The New York Times reported. The findings were posted online on Thursday, but have not yet been peer-reviewed or published in a scientific journal. “This puts the issue to rest — there is certainly no mortality benefit,” Dr. Ilan Schwartz, an infectious-disease physician at the University of Alberta in Canada, told The Times. However, another infectious-disease expert expressed caution about the findings. A large trial like this that’s conducted in numerous countries with different health care systems can result in inconsistent treatment protocols whose effects can be difficult to analyze, Dr. Peter Chin-Hong, University of California, San Francisco, told ...
- Source: drugdu
- 745
- October 20, 2020
Covid-19
Russia approves a second vaccine

Last month, Russia announced the approval of a COVID-19 vaccine called Sputnik V. This week, President Vladimir Putin announced the approval of a second vaccine, called EpiVacCorona. As with the first, scientists have not yet tested this vaccine in phase 3 trials. The vaccine was developed by scientists at the State Virology and Biotechnology Center, known as Vektor, in Novosibirsk. According to The Moscow Times: “Early trials on 100 volunteers were said to have been successful.” In a televised news conference, Putin explained that researchers had given the vaccine to Deputy Prime Minister Tatyana Golikova and the head of Russia’s consumer safety watchdog, Anna Popova, as part of ongoing trials. During the briefing, they explained that: “Early trials on 100 volunteers were said to have been successful.” As with Sputnik V, experts are likely to view the new vaccine with skepticism. Vaccines must be rigorously investigated before they can be used widely, and ...
- Source: drugdu
- 648
- October 19, 2020
Covid
Moderna coronavirus vaccine shows ‘promising’ safety and immune response results in published Phase 1 study, but more research is needed

(CNN)A Covid-19 vaccine developed by the biotechnology company Moderna in partnership with the National Institutes of Health has been found to induce immune responses in all of the volunteers who received it in a Phase 1 study.
- Source: drugdu
- 714
- July 15, 2020
coronavirus vaccine Covid-19 vaccine
Should Chloroquine Be Used to Treat Covid-19?

As the fight against the Coronavirus rages, the debate surrounding the possible use of chloroquine and a derivative, hydroxychloroquine, is heating up.
- Source: drugdu
- 844
- May 19, 2020
Chloroquine Covid-19 vaccination
AZ’s Farxiga Gets FDA Priority Review For Heart Failure

AstraZeneca has got off to a strong start in 2020, with the FDA granting a fast review for its diabetes drug Farxiga in heart failure and China approving Lokelma for hyperkalemia.
- Source: https://scrip.pharmaintelligence.informa.com/SC141424/AZs-Farxiga-Gets-FDA-Priority-Review-For-Heart-Failure
- 2,090
- January 8, 2020
AstraZeneca Farxiga FDA Lokelma
What ingredients are in vaccines?

Vaccines are a central player in our fight against infectious diseases. What components are commonly found in vaccines, and what is their purpose? In this Special Feature article, we find out. Why do some vaccines have a long list of components? Many people will be familiar with the concept that a vaccine against a particular virus will contain a small amount of the pathogen or a part of it, at least. When we receive the vaccine, the viral interloper triggers our immune system to launch a series of events that leave us protected against the pathogen in the future. But a glance at the ingredients in common vaccines reveals a long list of other components, the roles of which might not seem so clear cut. What is the purpose of the likes of gelatin, thimerosal, and Polysorbate 80? And why do some vaccines contain aluminum? In this Special Feature article, ...
- Source: drugdu
- 1,724
- December 17, 2019
Ddu College ingredient vaccine

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