PharmaFocus Today – Page 434 – media

Alzheimer’s Association report highlights need to improve patient-physician communication Both individuals and primary care physicians reported a reluctance to address cognitive concerns

A new report from the Alzheimer’s Association has highlighted a need to improve patient-physician communication surrounding cognitive concerns. Following results from its 2023 Alzheimer’s Disease Facts and Figures report, the organisation said that a reluctance by the public and doctors to address memory and thinking worries hinders diagnosis and access to potential new treatments. “Providing the best possible care for Alzheimer’s disease requires conversations about memory at the earliest point of concern and a knowledgeable, accessible care team that includes physician specialists to diagnose, monitor disease progression and treat when appropriate,” said Maria Carrillo, chief science officer, Alzheimer’s Association. An accompanying report, The Patient Journey In an Era of New Treatments, also provides new insights from patients and primary care physicians (PCPs) on the current barriers to addressing cognitive concerns. Most focus group participants said their memory and thinking problems would need to have a significant ...
- Source: drugdu
- 173
- March 28, 2023
Chiesi Group and Affibody AB partner on respiratory disease treatments The companies will progress up to three programmes against undisclosed target

The Chiesi Group and Affibody AB have announced a collaboration and licensing agreement aimed at developing and commercialising innovative treatments for respiratory diseases. The partnership will see both companies utilise Affibody’s proprietary technology to progress up to three programmes against undisclosed targets for respiratory diseases. Italy-based biopharma Chiesi will fund all discovery, development and subsequent commercialisation worldwide alone, with Affibody retaining the option to co-promote in the Nordic region. The small size of Affibody’s molecules in combination with their robustness allows for the unique attributes explored under this collaboration, the companies explained, such as broad distribution and sustained exposure in the lung, as seen in preclinical models. David Bejker, chief executive officer of Affibody, said: “This collaboration with Chiesi accelerates Affibody’s strategic development and further reinforces the competitiveness of our technology which has now been validated both clinically and commercially. “We acknowledge and appreciate Chiesi’s ...
- Source: drugdu
- 162
- March 28, 2023
Complications, pathophysiology, and treatment of type 2 diabetes differ by sex

In a recent review published in the journal Diabetologia, researchers in Austria discussed the sex-based differences in the risk factors, diagnosis, and therapeutic approaches for type 2 diabetes and associated complications to improve awareness about and management options for all diabetes type 2 patients. Background Studies show that patterns associated with type 2 diabetes vary according to sex, with the prevalence of the disease being higher among the young to middle-aged male population but the increase in postprandial glucose levels being higher among women and increasing with age. Furthermore, the varying clinical outcomes based on sex depend on the influence of hormonal and genetic factors on the diagnoses, therapeutic response, clinical outcomes, and pathophysiology. Therefore, because of the varying levels of sex hormones, the risk of type 2 diabetes and other cardiometabolic diseases also varies significantly for women. Additionally, substantial sex-based differences in lifestyles, behaviors, and approaches ...
- Source: drugdu
- 201
- March 28, 2023
Link found between late eating and higher consumption of ultra-processed foods

Bonaccio M, Ruggiero E, Di Castelnuovo A, et al. Association between Late-Eating Pattern and Higher Consumption of Ultra-Processed Food among Italian Adults: Findings from the INHES Study. Nutrients, 2023, DOI: 10.3390/nu15061497, https://www.mdpi.com/2072-6643/15/6/1497 In a recent study published in the journal Nutrients, researchers in Italy examined the associations between meal timing and food processing. Unhealthy diets are risk factors for obesity and related disorders. As such, strategies to tackle obesity have been focused on food compositions, resulting in recommendations to lower sugar, salt, and fat intake, with a concomitant increase in fiber, vitamin, and mineral intake. Much research has been centered on meal timing, with population studies implicating late eating in obesity and nutrition-related non-communicable diseases. Nonetheless, no study has investigated the relationship between meal timing and processed foods. About the study In the present study, researchers evaluated whether meal timing is associated with foods with different ...
- Source: drugdu
- 185
- March 28, 2023
Patients losing out amid slump in NHS clinical trials, warn top clinicians UK falls from fourth to 10th place in phase III trials amid ‘ossified’ bureaucracy and stretched health service

The state of clinical trials in the NHS is “much worse than it has been in years” with patients losing access to cutting-edge cancer and dementia treatments, one of the UK’s most senior clinicians has warned. Sir John Bell, the regius professor of medicine at the University of Oxford and a government life sciences adviser, said the UK’s approach needed “a full overhaul, top to bottom” to prevent a collapse in the number of clinical trials being conducted in the NHS. “I don’t think there’s any doubt that companies are choosing not to evaluate their drugs in the UK,” he said. “The risks [to patients] are much bigger than have been alluded to.” The intervention comes after the government launched an independent review led by the former health minister James O’Shaughnessy into why the NHS had seen a 44% drop in participants recruited to commercial clinical trials in the past five years. The UK is rapidly ...
- Source: drugdu
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- March 28, 2023
GSK reports positive phase 3 results for five-in-one meningococcal vaccine candidate There are currently no licensed vaccines offering simultaneous protection against all five serogroups

GSK has reported positive top-line results from a phase 3 study of its five-in-one meningococcal vaccine candidate, MenABCWY, in healthy individuals aged ten to 25 years. Invasive meningococcal disease (IMD) is an uncommon but serious illness that can cause life-threatening complications or even death, with the highest incidence occurring in children and adolescents. Five Neisseria meningitides serogroups – A, B, C, W, and Y – account for nearly all IMD cases, but there are currently no licensed vaccines that offer simultaneous protection against all of them. In the US, two separate vaccines needing four injections are required to protect against all five serogroups. This regimen, together with low awareness of the disease, can lead to poor immunisation rates, with an estimated coverage of only 31% of adolescents in the US. It is hoped that GSK’s MenABCWY, which combines the antigenic components of its licensed Bexsero (MenB) and Menveo (MenACWY) meningococcal ...
- Source: drugdu
- 211
- March 27, 2023
new research New data suggests ‘huge overuse of antibiotics’

Most patients who are admitted to hospitals with acute viral infections are given antibiotics by their doctors or health care providers as a precaution against bacterial co-infection. Yet new research suggests this practice may not improve their survival rates. Researchers investigated the impact of antibiotic use on survival in more than 2,100 patients in a hospital in Norway between the years 2017 and 2021, Reuters reported. ‘SILENT PANDEMIC’ WARNING FROM WHO: BACTERIA KILLING TOO MANY PEOPLE DUE TO ANTIMICROBIAL RESISTANCE The researchers found that giving antibiotics to people with common respiratory infections was unlikely to lower the risk of death within 30 days. At the height of the COVID-19 pandemic, antibiotics were prescribed for around 70% of COVID-19 patients in some countries, Reuters also said. This potentially has contributed to the scourge of antibiotic-resistant pathogens known as superbugs. The new data has not been published in a medical journal ...
- Source: drugdu
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- March 27, 2023
Users of recalled eye drops describe permanent vision problems after infections

Renee Martray of South Carolina has severe and permanent corneal scarring resulting in vision loss. She says it’s like trying to peer through eyeglasses that have been dipped in oil. Nancy Montz of Ohio developed a corneal ulcer, spent three weeks in the hospital and lost vision in her left eye. Carla Oliva of Florida developed a severe eye infection and, when treatment failed, had to have her right eye removed. She’s now legally blind. The women said their problems began after they used EzriCare Artificial Tears, which is part of a US Centers for Disease Control and Prevention and US Food and Drug Administration investigation into a multistate outbreak of a rare strain of bacteria. EzriCare said in a statement last month that when it learned of the investigation January 20, it was not aware of any testing that definitively linked the outbreak to its product. “Nonetheless, we immediately ...
- Source: drugdu
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- March 27, 2023
FT

Pfizer and European Commission officials have waded through months of pushback over a large, controversial COVID-19 vaccine supply deal in Europe. They’ve now reportedly hashed out a new supply agreement—but there’s a catch. Under the terms of a revised deal, Pfizer agreed to extend the European supply contract from 2023 out to 2026, the Financial Times reports based on two people with knowledge of the talks. Given the drop in vaccine use, Pfizer also agreed to cut the total number of doses to be supplied by 40%, but the company is also pushing for payment for the doses that will never be manufactured, according to the publication. Pfizer and the European Commission (EC) inked their large vaccine supply deal in May 2021. The agreement covered 900 million vaccine doses for delivery split between 2022 and 2023, with the option for the EC to order another 900 million doses in the future. In December 2021, European officials exercised part of ...
- Source: drugdu
- 589
- March 24, 2023
England’s NICE signs off on PTC Therapeutics’ $3.7M gene therapy for ultra-rare disease

The National Institute for Health and Care Excellence (NICE) has recommended the therapy to treat patients with aromatic L-amino acid decarboxylase (AADC) deficiency who are 18 months and older. PTC has inked a confidential discount access scheme to make Upstaza available to the National Health Service (NHS), NICE says. The drug carries a list price of 3 million pounds sterling (around $3.71 million) per 0.5-mL infusion solution before the confidential discount. AADC deficiency is so rare that it affects an estimated 10 children in the U.K., only a few of whom could be eligible for the treatment. The disease causes a wide range of severe symptoms, but around 80% of patients have a severe form that leaves them fully dependent on caregivers and unable to meet normal developmental milestones. Due to the rarity of this condition, there isn’t much research on the expected life span of a person with AADC deficiency. It’s estimated that most ...
- Source: drugdu
- 183
- March 24, 2023

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