Study Shows Cytokines Worsens Lupus
May 23, 2018
Source: Ddu
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The autoimmune disease named Lupus affects nearly one in 1000 people and could lead to various symptoms ranging from joint and skin problems to organ damage. The exact cause is unknown but genes play a major role in contracting lupus. This condition usually affects women more than men.
A research study led by Professor Marina Botto, from the Department of Medicine in Imperial College London, revealed that a particular component of the immune system called C1q triggers an alarm when the body is attacked by a bacteria or virus and helps in coordinating the defense. C1q controls the functions of cytotoxic T-cells or CD8 T cells. They safeguard the immune system and destroy the pathogens or cancerous cells.
But when the patients have a higher level of cytotoxic T-cells, they tend to have more severe forms of autoimmune diseases like lupus.
Professor Marina Botto said, "I've been working with lupus for many years, and we've only recently realized these cytotoxic cells – which have such a crucial role in protecting the body against viruses, may also play a key role in the disease."
This discovery is now a major part of the focus of the research team’s further studies to control lupus.
By Ddu
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