Dongyangguang Pharmaceutical’s first anti-Nipah virus “lifesaving drug” has entered clinical trials, achieving a 100% mortality protection rate in animal prevention.
February 25, 2026
Source: drugdu
29
On February 24, Dongyangguang Pharmaceutical (06887) issued an announcement stating that the Center for Drug Evaluation of the National Medical Products Administration of China has formally accepted the company's application for clinical trials of HEC-648 injection, a monoclonal antibody new drug targeting the Nipah virus G protein. Phase I clinical research is expected to be officially launched in 2026.
Nipah virus is a highly lethal single-stranded negative-sense RNA virus, with a mortality rate ranging from 40% to 75%. Currently, Nipah virus is classified as a biosafety level 4 virus, and there are no approved targeted treatments or vaccines available.。
HEC-648 injection is a fully human monoclonal antibody targeting the Nipah virus G protein, a research achievement of the Wuhan Institute of Virology, Chinese Academy of Sciences. In animal model experiments, this drug demonstrated a 100% preventative mortality protection rate and over 80% therapeutic mortality protection rate, making it the first and only specific drug developed in China for Nipah virus to enter the clinical registration stage.
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