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• ASC30 Completes First Dosing in US Phase II Clinical Trial for Diabetes Treatment On January 26, Ascletis Pharma (01672) announced that it had completed dosing of the first subjects in its Phase II US study of the oral small molecule GLP-1R agonist ASC30 for the treatment of diabetes. Top-line data from the study are expected to be available in the third quarter of 2026. 　　A 13-week study in obese or overweight subjects showed that ASC30 resulted in a placebo-adjusted weight loss of up to 7.7%, with better gastrointestinal tolerability and no liver safety signals observed. The study enrolled 125 obese subjects or overweight subjects with at least one weight-related comorbidity. 　　At the primary endpoint of week 13, once-daily doses of ASC30 tablets at 20 mg, 40 mg, and 60 mg resulted in weight loss of 5.4%, 7.0%, and 7.7%, respectively, which were statistically significant and clinically meaningful. The overall discontinuation rate due to adverse events was 4.8%. 　　ASC30 is the first small molecule GLP-1R fully biased agonist currently in clinical trials, and is indicated for the treatment of obesity, diabetes and other metabolic diseases. 网址：https January 26, 2026